Preparation method of acellular dermal matrix and prepared acellular dermal matrix
An acellular dermis, acellular technology, applied in medical science, tissue regeneration, bandages, etc., can solve the problems of acellular incomplete immunogenicity, low immunogenicity, etc., achieve good mechanical properties, low antigenicity, biological good compatibility
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[0100] The present invention provides a method for preparing an acellular dermal matrix and the prepared acellular dermal matrix. Those skilled in the art can learn from the content of this article and appropriately improve the process parameters to realize it. In particular, it should be pointed out that all similar replacements and modifications are obvious to those skilled in the art, and they are all considered to be included in the present invention. The method and application of the present invention have been described through preferred embodiments, and relevant personnel can obviously make changes or appropriate changes and combinations to the method and application herein without departing from the content, spirit and scope of the present invention to realize and apply the present invention Invent technology.
[0101] The test materials and instruments used in the present invention are all common commercial products and can be purchased in the market.
[0102] The ol...
Embodiment 1
[0104] Example 1: Preparation method of heterogeneous acellular dermal matrix
[0105] a. Process for preparing split skin slices: choose Parmesan pigskin as the skin source, depilate and disinfect the skin-taking area, make the animal skin into slices with a thickness of 1.0mm with a skin-taking machine, and use a puncher to Fractured skin slices were made into sliced skin slices of different shapes; soaked in 1‰ benzalkonium chloride solution for 30 minutes, degreased and sterilized;
[0106] b. Virus inactivation process: the virus inactivation solution composed of peracetic acid with a mass fraction of 1.0% and sodium chloride with a mass fraction of 3.0% was used to inactivate the tomographic skin for 45 minutes. The ratio is 1:5;
[0107] c, degreasing process: adopt the mixed degreasing agent that mass fraction 2.0% soda ash, mass fraction 2.0% caustic soda and mass fraction 0.5% surfactant form to carry out degreasing 30-60 minute, described surfactant is Ping Ping,...
Embodiment 2
[0114] Example 2: Preparation method of heterogeneous acellular dermal matrix
[0115] a, preparation process of split skin: choose Parmesan pigskin as the skin source, depilate and disinfect the skin area, use the skin machine to make the animal skin into a split skin with a thickness of 0.1mm, and punch it with a punch Fractured skin slices were made into sliced skin slices of different shapes; soaked in 1‰ benzalkonium chloride solution for 20 minutes, degreased and sterilized;
[0116] b. Virus inactivation process: The virus inactivation solution composed of peracetic acid with a mass fraction of 0.1% and sodium chloride with a mass fraction of 1.0% was used to inactivate the tomographic skin for 30 minutes. The ratio is 1:4;
[0117] C, degreasing process: adopt the mixed degreasing agent that mass fraction 1.0% soda ash, mass fraction 1.0% caustic soda and mass fraction 0.1% surfactant form to degrease 30 minutes, described surfactant is sodium lauryl aminopropionate...
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