30results about How to "Strong resistance to degradation" patented technology

The invention discloses a macromolecule cross-linking agent based on oxidized cellulose, a gelatin film thereof and a preparation method. The preparation method of the gelatin film comprises the following steps: 1, oxidizing a primary amino group on the C6 position of cellulose into carboxyl through a TEMPO / NaBr / NaClO system, and obtaining oxidized cellulose TOMCC; 2, treating N-hydroxy succinimide and TOMCC obtained in step 1 as raw materials, and manufacturing a macromolecule cross-linking agent TMN; 3, making the macromolecule cross-linking agent TMN be subjected to chemical cross-linking with a gelatin film, and obtaining the food package gelatin film based on oxidized cellulose chemical cross-linking. Light-blocking performance, thermal stability, anti-biodegradation capability, the mechanical property (elasticity) and hydrophobicity of the gelatin film are all improved to a large extent, and a favorable condition is provided for application of the gelatin film to the food package field. In addition, biodegradation mechanisms of a modified gelatin film and a pure gelatin film in a phosphate buffered solution (PBS) and lysozyme are explored and analyzed as well.

The invention relates to a CO2 enriched type two-phase absorbent with rapid and spontaneous layering. The CO2 enriched type two-phase absorbent comprises the following components in percentage by mass: 30-60% of a phase splitting agent, 15-35% of an enriching agent, 0-25% of an accelerant and the balance of water, wherein the enriching agent is selected from one or more of cholamine, hydroxyethylethylenediamine, 3-amino-1-propanol, N-methyl-2-hydroxy ethylamine, ethyl oxyethylamine and isopropanolamine. By adopting the two-phase absorbent, the spontaneous phase splitting time of the two-phaseabsorbent is effectively shortened, and the phase splitting load range that the two-phase absorbent spontaneously forms liquid-liquid phases is increased.

The invention relates to an ophthalmic medical appliance and a manufacture method of the ophthalmic medical appliance, in particularly to a biomembrane material strip belt for a high-myopia posterior scleral reinforcement surgery. Base materials of the biomembrane material strip belt have a wide resource, the biomembrane material strip belt is blue after the treatment, the manufactured blue biomembrane material strip belt has good visuality and cannot easily get lost in the implantation process; the hardness and the elasticity are proper, the adaptability is good, the implantation is easy, and the biomembrane material strip belt is easily pasted, sewed and fixed with a receptor sclera; after the implantation into the human body, the toxicity is low, the mechanical strength is high, the tissue compatibility is good, the degradation resistance capability is high, and the calcification is not easy to occur; and the whole body of the biomembrane material strip belt is in a fusiform shape, the thickness is 0.15 to 0.45mm, the side part is an inclined surface, the middle section is widest, the middle section is gradually narrowed in arc-shaped transition respectively towards the left end and the right end, the length is 30 to 60mm, the width of the middle section is 10 to 16mm, the width of the left and the right end is 2 to 3mm, through the special shape design of the strip belt, the venae vorticosae can be prevented from being pressed, the reinforcement range is enlarged, the inclined surface of the side part is in 30 to 45 degrees, the marking at the positive surface and the opposite surface is realized, and the twisting turning is not easy to cause during the implantation.

The invention relates to the technical field of tissue engineering, in particular to a preparation method of an acellular dermal matrix and the prepared acellular dermal matrix. By means of the provided preparation method of the acellular dermal matrix, cell ingredients can be cleanly removed, the antigenicity is low, the dermal collagen structures are reserved, the heterologous DNA content is very low, and good mechanical performance is obtained.

The invention discloses a biologic sclera contraction band and a preparing method thereof. The biologic sclera contraction band is in a band as a whole; the cross section of the biologic sclera contraction band is arc-shaped; the biologic sclera contraction band is thickest in the middle and gradually becomes narrower from the middle to the two sides through arc-shaped transition; the whole length of the biologic sclera contraction band is 3-40mm; the middle thickness of the biologic sclera contraction band is 1-3mm; the thickness of the two sides of the biologic sclera contraction band is 0.5-2mm; the band width of the biologic sclera contraction band is 3-8mm. The biologic sclera contraction band can be applied to combination with a biologic posterior sclera reinforcing band, can contract sclera and limit the expansion of the sclera, is used for treating high myopia macular retinal detachment, full retinal detachment and other certain non-incremental retinal detachments and better keeps and protects retinal structures and functions. The base material of the biologic sclera contraction band is taken from the trachea, ligament, trunk vessel or cartilage of an animal, the strength is increased through genipin cross-linking solidifying treatment, the elasticity and the hardness are proper, and the biologic sclera contraction band cannot be easily absorbed, has great tissue compatibility, causes few complications and overcomes the defects of the conventional retinal detachment intra and extra surgeries.

The invention provides a feed additive containing L-lysine. The feed additive consists of coated core particles and coating layers covering the coated core particles, wherein the coating layers are rumen-protected fat; and a preparation method of the coated core particles comprises the following steps: uniformly mixing lysine salt and a filler as well as optional sodium glutamate, adding an optional adhesive solution containing xylanase, sieving, shot-blasting, drying and sieving. In addition, the invention further provides a preparation method of the feed additive, wherein the preparation method comprises a step of spraying the rumen-protected fat on the coated core particles.

The invention relates to a CO2 enriched type two-phase absorbent with rapid and spontaneous layering. The CO2 enriched type two-phase absorbent comprises the following components in percentage by mass: 30-60% of a phase splitting agent, 15-35% of an enriching agent, 0-25% of an accelerant and the balance of water, wherein the enriching agent is selected from one or more of cholamine, hydroxyethylethylenediamine, 3-amino-1-propanol, N-methyl-2-hydroxy ethylamine, ethyl oxyethylamine and isopropanolamine. By adopting the two-phase absorbent, the spontaneous phase splitting time of the two-phaseabsorbent is effectively shortened, and the phase splitting load range that the two-phase absorbent spontaneously forms liquid-liquid phases is increased.

The invention provides a biomimetic biomineralized artificial bone repair material and its preparation method and application. The material includes a crosslinked collagen matrix and biomineralized collagen / hydroxyapatite composite powder dispersed in the matrix. The mass ratio of the collagen matrix to the biomineralized collagen / hydroxyapatite composite powder is 9:1˜1:9. The biomimetic biomineralized artificial bone repair material of the present invention is a collagen-based biomimetic biomineralized artificial bone, which can meet the needs of artificial bone and tissue suturing in GTR or GBR clinical operations. It includes hydroxyapatite and pure collagen. This component is the main component of human natural tissue, non-toxic, and does not affect the material structure and bone formation effect, and has good biocompatibility. Due to the existence of the cross-linked collagen matrix, the problems of easy collapse, fast degradation, and poor mechanical properties of the material are solved, and the bionic construction of nano-hydroxyapatite and collagen is realized.

The invention discloses a functional cellulose esterification based chemical cross-linking agent modified gelatin compound with the constitutional unit shown as formula I (n=200-500) below. The invention further discloses a preparation method of the modified gelatin compound, and the modified gelatin compound is obtained by amidation of a macromolecular cross-linking agent and gelatin. Heat stability, biodegradability resistance, mechanical property and surface hydrophobicity of the cross-linking agent modified gelatin compound are remarkably improved; particularly, a freeze dried composite gelatin network is remarkably improved, and honeycomb-cell-shaped surface microtopography provides a dwelling location for loading and embedding of drugs, so that favorable conditions are provided for application of the gelatin compound as drug carriers.

The invention belongs to the technical field of fuel cells, and specifically relates to an anti-degradation enhanced proton exchange membrane and a preparation method thereof. The casting liquid containing a vitamin free radical quencher is scraped and coated on the reinforcing material until the film is formed. The proton exchange membrane prepared by the invention has strong degradation resistance. For the first time, the use of vitamin compounds as the free radical quencher carried by the proton exchange membrane is proposed. It is cheap and easy to obtain, has little harm to the environment, and has good free radical The reducibility and anti-free radical degradation performance are improved, and the hydrogen permeation of the proton exchange membrane can be used to reduce vitamins, realize the reuse of free radical quenchers, and also reduce the effect of hydrogen permeation on the membrane electrode aging of fuel cells.

The invention provides a high-strength tissue regeneration membrane. The material includes a dense layer and a loose layer. During the preparation process, through the gradient dialysis process, the molecules are re-formed into an ordered structure, with more consistent and wider collagen fiber orientation, thereby improving the mechanical properties of the material. The mechanical properties of the material are similar to those of human tissue, and sutures can be used for suturing operations, and can be used to guide tissue regeneration or guide bone tissue regeneration. The invention also provides a preparation method of the high-strength tissue regeneration membrane.

The present invention provides the use of sodium glutamate in the method of preparing L-lysine-containing products coated with rumen fat or in improving the degradation resistance of L-lysine-containing products coated with rumen fat application. In addition, the present invention also provides the corresponding L-lysine-containing product and its preparation method.

The invention provides a heterogeneous scleral piece used for posterior scleral reinforcement and a preparation method thereof. According to the heterogeneous scleral piece, the base materials are wide in sources, the hardness and the elasticity are proper, the adaptability is good, the heterogeneous scleral piece is easy to implant and can be attached, sewn and fixed with a receptor scleral easily; after being implanted into a human body, the heterogeneous scleral piece is non-toxic, high in mechanical strength, good in histocompatibility, strong in anti-degradation capability, can not be calcified easily, and does not have rejection reaction, and scars can not be left; and due to the special shape design of the scleral piece, venae vorticosae can be prevented from being pressed and damaged, the sclearl piece can not be twisted and turned easily in the implanting and penetrating process, and can be left in the body for a long time, the complication caused by the frequency operations can be avoided, and the effect of treating the progressive myopia and the high myopia for a long time is achieved.

The invention discloses a collagen melanocyte compound as well as a preparation method and an application thereof. The collagen material is a scaffold material which is prepared on the basis of a tissue engineering technology and has good biocompatibility, mechanical performance and degradation performance. The invention relates to preparation of a collagen scaffold and construction of a collagen melanocyte compound. The melanocytes have high cell activity and excellent melanin secretion ability on the scaffold material. The collagen melanocyte compound avoids the loss of cell suspension in the cell transplantation process, and provides a good three-dimensional growth environment for cells. The collagen melanocyte compound prepared by the invention can be used for leucoderma patients or pigment deficiency and epidermal layer injury patients.

The invention discloses a method for preparing a silk fibroin / gelatin interpenetrating network hydrogel capable of encapsulating cells, comprising the following steps: 1) mixing a silk fibroin solution and a modified gelatin solution to form a prepolymer solution, and feeding Adding a photoinitiator to the prepolymer solution; 2) Ultrasonic treatment of the solution obtained in step 1), the solution has fluidity and transparency after ultrasonic treatment; 3) The solution obtained in step 2) is mixed evenly with cells to obtain a cell prepolymerization solution, and further Place the cell pre-polymerization solution in a petri dish; 4) put the petri dish obtained in step 3) under ultraviolet light for photo-crosslinking to form a gel, and then place it in a 37°C incubator until the mold solution turns milky white. . The method can realize cell adhesion proliferation and three-dimensional encapsulation in situ, and is beneficial to the three-dimensional construction of cartilage tissue in vitro. The maximum swelling rate of the prepared hydrogel is 11.3754±0.29; the maximum elastic modulus can reach 600kPa±5kpa; it has strong enzymatic degradation resistance.

The invention discloses a macromolecule cross-linking agent based on oxidized cellulose, a gelatin film thereof and a preparation method. The preparation method of the gelatin film comprises the following steps: 1, oxidizing a primary amino group on the C6 position of cellulose into carboxyl through a TEMPO / NaBr / NaClO system, and obtaining oxidized cellulose TOMCC; 2, treating N-hydroxy succinimide and TOMCC obtained in step 1 as raw materials, and manufacturing a macromolecule cross-linking agent TMN; 3, making the macromolecule cross-linking agent TMN be subjected to chemical cross-linking with a gelatin film, and obtaining the food package gelatin film based on oxidized cellulose chemical cross-linking. Light-blocking performance, thermal stability, anti-biodegradation capability, the mechanical property (elasticity) and hydrophobicity of the gelatin film are all improved to a large extent, and a favorable condition is provided for application of the gelatin film to the food package field. In addition, biodegradation mechanisms of a modified gelatin film and a pure gelatin film in a phosphate buffered solution (PBS) and lysozyme are explored and analyzed as well.

The invention discloses a new micro-molecular compound YZC-J-1 in the chemibiological domain, which is characterized by the following: killing hepatocarcinoma cell and tissue with little side-effect; possessing simple structure; intaking easily; complementing superiority of present antineoplastic drug.

The present invention provides a preparation method of high-strength bionic collagen membrane. The preparation method is by conducting gradient dialysis process on collagen to rearrange collagen molecules into an ordered structure, and endow the molecules with more consistent and more extensive collagen fiber orientation, thus improving the mechanical properties of the material. The collagen membrane prepared by using the method has similar appearance, structure and performance to natural dura and amnion of mammals, and good rehydration, and is free to bend and fold after water absorption; the bionic collagen membrane with high tensile strength can be stitched by using suture and can be used in clinical guided tissue regeneration or repair of various tissues.

The invention relates to the technical field of oil and gas field development, in particular to a fracturing fluid thickener and a preparation method thereof. The method includes preparing an inner water-based phase and an oil-based phase, emulsification polymerization, preparing an outer water-based phase, emulsification polymerization and post-treatment steps. The present invention adopts reverse-phase polymerization technology and internal and external two-phase polymerization, firstly prepares highly salt-resistant self-assembled polymers, and then grafts macromolecular monomers through chain extenders to form a molecular structure with extremely strong rigidity. The treatment reduces the degradation effect of ferrous ions on the thickener during use, and the obtained supramolecular structure makes the polymer not only have high salt resistance characteristics, but also has strong resistance to free radicals, making the polymer extremely strong anti-degradation properties.

The invention relates to the technical field of forensic genetics identification, and particularly discloses a genetic marker of 191 human microhaplotype loci as well as an amplification primer and application thereof. The 191 human micro-haplotype locus genetic marker provided by the invention combines the advantages of STR and SNP, and has the advantages of short amplified fragment, low mutation rate, good polymorphism and no stutter peak. When the 191 human micro-haplotype locus genetic marker provided by the invention is used for genetic relationship identification, the two-layer genetic relationship identification between two individuals can be independently solved, the requirement that only two persons participate in identification in the secondary genetic relationship such as the secondary genetic relationship of the cassytha, the secondary genetic relationship of the arrowhead and the secondary genetic relationship of the unconsciousness and the secondary genetic relationship of the unconsciousness and the secondary genetic relationship of the unconsciousness and the secondary genetic relationship of the unconsciousness are met, and the The method has good repeatability and extremely high sensitivity and stability. In forensic medicine identification, the method has obvious anti-degradation capability, and has extremely high application value in forensic actual detection cases.

The invention discloses an application of new quinoxaline compound in the tumour-proof drug domain, which is characterized by the following: avoiding each untoward effect; possessing low side-effect.

The invention discloses a wound repairing material for cell suspension transplantation and a preparation method thereof. The wound repairing material includes a collagen base layer, and the collagen base layer is prepared from a three-dimensional porous collagen sponge through tableting treatment. The collagen sponge is made of The raw materials including the collagen-based composite solution are prepared through cross-linking treatment, and the collagen-based composite solution includes type I collagen and composite material, and the composite material is elastin or anionic mucopolysaccharide. The collagen base layer in the wound repair material for cell suspension transplantation of the present invention can be used as a supporting scaffold for epidermal cell adhesion, proliferation and migration, and provides a suitable microenvironment for wound healing. The wound repair material combined with autologous epidermal cell suspension can quickly seal Donor sites, superficial burn wounds of patients with extensive burns, and superficial chronic skin ulcer wounds have good application prospects in cell suspension transplantation.