30results about How to "Strong resistance to degradation" patented technology

The invention discloses a biologic sclera contraction band and a preparing method thereof. The biologic sclera contraction band is in a band as a whole; the cross section of the biologic sclera contraction band is arc-shaped; the biologic sclera contraction band is thickest in the middle and gradually becomes narrower from the middle to the two sides through arc-shaped transition; the whole length of the biologic sclera contraction band is 3-40mm; the middle thickness of the biologic sclera contraction band is 1-3mm; the thickness of the two sides of the biologic sclera contraction band is 0.5-2mm; the band width of the biologic sclera contraction band is 3-8mm. The biologic sclera contraction band can be applied to combination with a biologic posterior sclera reinforcing band, can contract sclera and limit the expansion of the sclera, is used for treating high myopia macular retinal detachment, full retinal detachment and other certain non-incremental retinal detachments and better keeps and protects retinal structures and functions. The base material of the biologic sclera contraction band is taken from the trachea, ligament, trunk vessel or cartilage of an animal, the strength is increased through genipin cross-linking solidifying treatment, the elasticity and the hardness are proper, and the biologic sclera contraction band cannot be easily absorbed, has great tissue compatibility, causes few complications and overcomes the defects of the conventional retinal detachment intra and extra surgeries.

The invention relates to a CO2 enriched type two-phase absorbent with rapid and spontaneous layering. The CO2 enriched type two-phase absorbent comprises the following components in percentage by mass: 30-60% of a phase splitting agent, 15-35% of an enriching agent, 0-25% of an accelerant and the balance of water, wherein the enriching agent is selected from one or more of cholamine, hydroxyethylethylenediamine, 3-amino-1-propanol, N-methyl-2-hydroxy ethylamine, ethyl oxyethylamine and isopropanolamine. By adopting the two-phase absorbent, the spontaneous phase splitting time of the two-phaseabsorbent is effectively shortened, and the phase splitting load range that the two-phase absorbent spontaneously forms liquid-liquid phases is increased.

The invention provides a biomimetic biomineralized artificial bone repair material and its preparation method and application. The material includes a crosslinked collagen matrix and biomineralized collagen / hydroxyapatite composite powder dispersed in the matrix. The mass ratio of the collagen matrix to the biomineralized collagen / hydroxyapatite composite powder is 9:1˜1:9. The biomimetic biomineralized artificial bone repair material of the present invention is a collagen-based biomimetic biomineralized artificial bone, which can meet the needs of artificial bone and tissue suturing in GTR or GBR clinical operations. It includes hydroxyapatite and pure collagen. This component is the main component of human natural tissue, non-toxic, and does not affect the material structure and bone formation effect, and has good biocompatibility. Due to the existence of the cross-linked collagen matrix, the problems of easy collapse, fast degradation, and poor mechanical properties of the material are solved, and the bionic construction of nano-hydroxyapatite and collagen is realized.

The invention provides a high-strength tissue regeneration membrane. The material includes a dense layer and a loose layer. During the preparation process, through the gradient dialysis process, the molecules are re-formed into an ordered structure, with more consistent and wider collagen fiber orientation, thereby improving the mechanical properties of the material. The mechanical properties of the material are similar to those of human tissue, and sutures can be used for suturing operations, and can be used to guide tissue regeneration or guide bone tissue regeneration. The invention also provides a preparation method of the high-strength tissue regeneration membrane.

The invention discloses a collagen melanocyte compound as well as a preparation method and an application thereof. The collagen material is a scaffold material which is prepared on the basis of a tissue engineering technology and has good biocompatibility, mechanical performance and degradation performance. The invention relates to preparation of a collagen scaffold and construction of a collagen melanocyte compound. The melanocytes have high cell activity and excellent melanin secretion ability on the scaffold material. The collagen melanocyte compound avoids the loss of cell suspension in the cell transplantation process, and provides a good three-dimensional growth environment for cells. The collagen melanocyte compound prepared by the invention can be used for leucoderma patients or pigment deficiency and epidermal layer injury patients.

The invention discloses a method for preparing a silk fibroin / gelatin interpenetrating network hydrogel capable of encapsulating cells, comprising the following steps: 1) mixing a silk fibroin solution and a modified gelatin solution to form a prepolymer solution, and feeding Adding a photoinitiator to the prepolymer solution; 2) Ultrasonic treatment of the solution obtained in step 1), the solution has fluidity and transparency after ultrasonic treatment; 3) The solution obtained in step 2) is mixed evenly with cells to obtain a cell prepolymerization solution, and further Place the cell pre-polymerization solution in a petri dish; 4) put the petri dish obtained in step 3) under ultraviolet light for photo-crosslinking to form a gel, and then place it in a 37°C incubator until the mold solution turns milky white. . The method can realize cell adhesion proliferation and three-dimensional encapsulation in situ, and is beneficial to the three-dimensional construction of cartilage tissue in vitro. The maximum swelling rate of the prepared hydrogel is 11.3754±0.29; the maximum elastic modulus can reach 600kPa±5kpa; it has strong enzymatic degradation resistance.

The invention discloses a new micro-molecular compound YZC-J-1 in the chemibiological domain, which is characterized by the following: killing hepatocarcinoma cell and tissue with little side-effect; possessing simple structure; intaking easily; complementing superiority of present antineoplastic drug.

The present invention provides a preparation method of high-strength bionic collagen membrane. The preparation method is by conducting gradient dialysis process on collagen to rearrange collagen molecules into an ordered structure, and endow the molecules with more consistent and more extensive collagen fiber orientation, thus improving the mechanical properties of the material. The collagen membrane prepared by using the method has similar appearance, structure and performance to natural dura and amnion of mammals, and good rehydration, and is free to bend and fold after water absorption; the bionic collagen membrane with high tensile strength can be stitched by using suture and can be used in clinical guided tissue regeneration or repair of various tissues.

The invention discloses an application of new quinoxaline compound in the tumour-proof drug domain, which is characterized by the following: avoiding each untoward effect; possessing low side-effect.