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High-strength tissue regeneration membrane and preparation method thereof

A technology of tissue regeneration membrane and regeneration membrane, which is applied in medical science, surgery, etc., can solve the problem of the degradation speed of materials that cannot be sutured with tissue, and achieve the effect of tight combination, high binding force, and enhanced ability to guide bone regeneration

Active Publication Date: 2015-08-26
BEIJING PAISHENG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to provide a high-strength tissue regeneration membrane and its preparation method against the defects of the above products. After absorbing water, the regeneration membrane becomes soft and has good tissue adhesion, and can be folded and bent in half. Attached to the surface of tissue of any shape, and the thickness of the material is very thin, while maintaining a high tensile strength at break, which solves the problem that the material cannot be sutured with the tissue, the degradation speed is too fast, and the thickness of the collagen film is too thick after absorbing water to cause tissue swelling, etc. problems, and does not require large-scale production equipment such as freeze dryers, and is easy to produce and promote

Method used

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  • High-strength tissue regeneration membrane and preparation method thereof
  • High-strength tissue regeneration membrane and preparation method thereof
  • High-strength tissue regeneration membrane and preparation method thereof

Examples

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Effect test

Embodiment 1

[0060] Example 1: Preparation of a high-strength tissue regeneration membrane, the dense layer and the loose layer are both type I collagen. figure 1 Shown is the flow chart of the preparation method of the high-strength tissue regeneration membrane of the present invention. figure 2 For the present invention implements the scanning electron micrograph of the compact layer of the regenerated membrane in dry state, Figure 3A , 3B A scanning electron micrograph of the loose layer of the regenerated membrane in a dry state for the implementation of the present invention.

[0061] according to figure 1 As shown in the steps, the preparation method of the high-strength type I collagen bilayer tissue regeneration membrane is:

[0062] Step S1-1, dissolving 1 g of type I collagen in 2 L of acetic acid solution with a concentration of 0.5 mol / L, and configuring it into a collagen acid solution;

[0063] Step S1-2, select a dialysis bag, put the collagen acid solution obtained in...

Embodiment 2

[0073] Example 2: Preparation of a high-strength tissue regeneration membrane, the dense layer is type I collagen, and the loose layer is type I collagen compounded with hydroxyapatite. figure 1 Shown is the flow chart of the preparation method of the high-strength tissue regeneration membrane of the present invention. Figure 4 For the present invention implements the scanning electron micrograph of the compact layer of the regenerated membrane in dry state, Figure 5A , 5B A scanning electron micrograph of the loose layer of the regenerated membrane in a dry state for the implementation of the present invention.

[0074] according to figure 1 In the steps shown, the preparation method of the high-strength type I collagen double-layer tissue regeneration membrane containing hydroxyapatite is:

[0075] Step S1-1, dissolving 1 g of type I collagen in 2 L of acetic acid solution with a concentration of 0.1 mol / L to form an acid solution of collagen;

[0076] Step S1-2, select ...

Embodiment 3

[0086] Example 3: Preparation of high-strength tissue regeneration membrane, the dense layer is a mixed material of type I and type III collagen, and the loose layer is type I collagen

[0087] according to figure 1 In the steps shown, the preparation method of the high-strength collagen bilayer tissue regeneration membrane is:

[0088] Step S1-1, take 0.3g type I collagen and 0.4g III collagen, dissolve in 1.1L acetic acid solution with a concentration of 0.2mol / L, and configure a mixed collagen solution of type I and III; take 0.5g type I collagen, dissolve in In 0.9L of acetic acid solution with a concentration of 0.2mol / L, prepare a type I collagen solution

[0089] Step S1-2, select a dialysis bag, put the collagen acid solution obtained in step S1-1 into the dialysis bag respectively, seal the port of the dialysis bag, and perform dialysis by gradient dialysis;

[0090] Step S1-3, the first gradient dialysis, the parameters are: pH=1 acetic acid solution for 2 days, th...

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Abstract

The present invention provides a high-strength tissue regeneration membrane. The material includes a dense layer and a loose layer. In the preparation process, a gradient dialysis process is carried out to rearrange molecules into an ordered structure, and endow the molecules with more consistent and more extensive collagen fiber orientation, thus improving the mechanical properties of the material. The mechanical properties of the material are similar to those of human tissues, and the material can be stitched by using sutures, and can be used to guide tissue regeneration or bone tissue regeneration. The present invention provides a preparation method of the high-strength tissue regeneration membrane.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a high-strength tissue regeneration membrane and a preparation method thereof. The material can be used to induce periodontal tissue regeneration or induce bone tissue regeneration. Background technique [0002] Guide Tissue Regeneration (GTR) technology is a new technology developed in the late 1980s and early 1990s. The principle is to use the physical barrier function of the membrane to isolate the lesion area from the surrounding tissue, creating a relatively closed tissue environment, so that the regenerative function of the specific tissue can be maximized. This technology was initially used in animal experiments and clinical studies for the treatment of periodontal disease, and was subsequently used to promote the repair and regeneration of bone tissue (ie induced bone tissue regeneration technology, Guide Bone Regeneration, GBR). Its application provides a new and effec...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/04A61L31/02A61L31/14
Inventor 符斌其他发明人请求不公开姓名
Owner BEIJING PAISHENG BIOTECH CO LTD
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