Bionic biomineralized artificial bone repair material as well as preparation method and application thereof

A technology of biomineralization and repair materials, applied in tissue regeneration, drug delivery, pharmaceutical formulations, etc., can solve the problems of excessive degradation speed, poor hydrophilicity, and poor binding degree, achieve a good three-dimensional space structure, improve mechanical Performance, good biocompatibility effect
CN107952115AActive Publication Date: 2018-04-24BEIJING PAISHENG BIOTECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING PAISHENG BIOTECH CO LTD
Publication Date
2018-04-24

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Abstract

The invention provides a bionic biomineralized artificial bone repair material as well as a preparation method and an application thereof. The material consists of a cross-linked collagen matrix and biomineralized collagen / hydroxyapatite composite powder dispersed in the matrix, wherein the mass ratio of the collagen matrix to the biomineralized collagen / hydroxyapatite composite powder is (9-1) to(1-9). The bionic biomineralized artificial bone repair material provided by the invention is a collage-based bionic biomineralized artificial bone, which can meet a demand of artificial bone and tissue suturing in a clinical GTR or GBR operation; the artificial bone repair material consists of hydroxyapatite and pure collagen, and the two ingredients are major ingredients of human natural tissues, so that the artificial bone repair material is free from toxicity; and influence to a material structure and an osteogenesis effect is avoided, and good biocompatibility is guaranteed. Due to the existence of the cross-linked collagen matrix, problems of a material which can get dispersed easily, and is too high in degradation speed, poor in mechanical performance and the like can be solved; and the bionic construction of nano-hydroxyapatite and collagen is achieved.
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Description

technical field

[0001] The invention relates to a bionic biomineralized artificial bone and a preparation method and application thereof, belonging to the field of biomedical materials. Background technique

[0002] Clinically, bone defects are mainly caused by trauma, infection, and tumors. In response to this situation, people have prepared a variety of substitute materials for bone repair through various methods or approaches, and achieved certain results.

[0003] Bone implant materials can be roughly divided into autologous bone, allograft bone, xenograft bone, and synthetic materials. Autologous bone transplantation is rarely used due to the limitation of its own donors; although the bone formation effect of allograft bone is better, it also has the risk of rejection and virus infection, and because of limited sources, it is difficult to achieve a large number of patients in clinical practice. Use; Xenograft bone is rarely used due to the large rejection reaction. Th...

Claims

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