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Blood-purifying adsorbent for clearing blood bilirubin and preparation method thereof

A technology of blood purification and adsorbent, which is applied in the field of biomedicine, can solve the problems of blocking and shading, the decrease of the ability to adsorb bilirubin, and the adsorption force and specificity are not very strong, so as to improve the adsorption performance and strong specific adsorption. Ability, physical and chemical property stabilization effect

Active Publication Date: 2013-04-24
佛山市博新生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, neutral macroporous adsorbents also have some drawbacks
Because it relies on the lipophilic and hydrophobic interactions of the adsorption resin to adsorb bilirubin, the adsorption force and specificity of itself are not very strong, resulting in unsatisfactory clinical results.
[0004] Anion exchange resin is also commonly used in blood purification to reduce bilirubin in the blood, but in order to achieve better blood compatibility, it is usually wrapped with PHEMA or other hydrophilic membranes, but this will block some effective pore size, resulting in a decrease in the ability to adsorb bilirubin

Method used

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  • Blood-purifying adsorbent for clearing blood bilirubin and preparation method thereof
  • Blood-purifying adsorbent for clearing blood bilirubin and preparation method thereof
  • Blood-purifying adsorbent for clearing blood bilirubin and preparation method thereof

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preparation example Construction

[0077] Such as figure 1 As shown, the embodiment of the present invention provides a method for preparing a blood purification adsorbent for removing blood bilirubin, including:

[0078] S101, dissolving the methacrylate-based bis-quaternary ammonium salt with 60-100% alcohol to obtain a methacrylate-based bis-quaternary ammonium salt solution with a concentration of 1-15%.

[0079] Preferably, the concentration of the alcohol is 75%; the concentration of the methacrylate-based bisquaternary ammonium salt solution is 2-8%.

[0080] S102, dissolving the initiator with purified water to obtain an initiator solution with a concentration of 5-18%.

[0081] Preferably, the concentration of the initiator solution is 8-12%.

[0082] Further preferably, the concentration of the initiator solution is 10%.

[0083] The initiator is ammonium persulfate, potassium persulfate or sodium persulfate-sodium bisulfite redox system.

[0084] Preferably, the initiator is ammonium persulfate. ...

Embodiment 1

[0173] Add 1 ml of 3% PDQ aqueous solution, 0.1 ml of 10% ammonium persulfate aqueous solution and 2 ml of 75% alcohol to 1 g of adsorbent resin (containing double bonds), and then under constant stirring of the mixture with a magnetic stirrer, Add 0.1 ml of 15% sodium sulfite aqueous solution, slowly mix the mixture at 40°C for 2 hours or at 10°C for 10 hours, filter the mixture, rinse with alcohol and wash with water.

Embodiment 2

[0175] Add 1.0 ml of 6% PDQ aqueous solution, 0.2 ml of 10% ammonium persulfate aqueous solution and 2 ml of 75% alcohol to 1 g of adsorption resin (containing double bonds), then stir the mixture at 40 °C for 2 hours, and filter the mixture , Rinse with alcohol and wash with water.

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Abstract

The invention discloses a blood-purifying adsorbent for clearing blood bilirubin and a preparation method thereof. The blood-purifying absorbent is fixed on a solid-phase carrier by adopting methacrylate biquaternary ammonium salt as aglucon through a chemical grafting method or a physical film-coating method, wherein the solid-phase carrier is a polymeric adsorbent. Correspondingly, the invention discloses a preparation method of the blood-purifying adsorbent for clearing blood bilirubin. According to the blood-purifying adsorbent disclosed by the invention, methacrylate biquaternary ammonium (PDQ for short) is adopted as the aglucon, so that not only can the special capacity for absorbing bilirubin be achieved, but also the compatibility of the adsorbent is remarkably improved. Meanwhile, the physical and chemical properties are stable, and the cost is relatively low.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a blood purification adsorbent for removing blood bilirubin and a preparation method thereof. Background technique [0002] The ability of the liver to process bilirubin is relatively strong. The daily metabolism of normal adults produces about 250 mg of bilirubin, which is transformed and excreted in time by the liver. When the excretion process is obstructed, the concentration of bilirubin in the blood will increase, resulting in hyperbilirubinemia. According to the etiology, jaundice can be divided into hemolytic jaundice, hepatocellular jaundice, cholestatic jaundice, and congenital non-hemolytic jaundice. Free bilirubin is lipophilic and has a high affinity for membrane lipids, and its binding impairs membrane function, especially nervous system function. When the concentration of unconjugated bilirubin in plasma exceeds 20-25 mg / dl, it can pass through the blood-brain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/30A61M1/38
Inventor 黄志攀姜建明
Owner 佛山市博新生物科技有限公司
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