A biomimetic biomineralized artificial bone repair material and its preparation method and application
A biomineralization and repair material technology, applied in drug delivery, tissue regeneration, pharmaceutical formulations, etc., can solve the problems of poor binding, poor hydrophilicity, and difficulty in becoming, and achieve the effect of increasing stability and not falling off easily
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Embodiment 1
[0077] In the preparation of the biomimetic biomineralized artificial bone in this example, hydrochloric acid was used as the acid solution, and CaCl was used as the calcium ion solution. 2 Aqueous solution, alkaline solution using NaOH aqueous solution, using ultraviolet radiation physical cross-linking method. figure 1 Shown is the flow chart of the preparation method of the biomimetic biomineralized artificial bone of the present invention.
[0078] according to figure 1 The steps shown, the preparation method of biomimetic biomineralization artificial bone is:
[0079] Step S1 (preparation of biomineralized collagen / hydroxyapatite composite powder) specifically includes:
[0080] Step S1-1 (dissolving collagen): dissolving 2 g of collagen in 1000 mL of hydrochloric acid solution with a concentration of 0.001 mol / L to prepare an acid solution of collagen, wherein the concentration of collagen is 0.2%, and the pH of the solution is 3;
[0081] Step S1-2 (adding calcium ...
Embodiment 2
[0097] In the preparation of the biomimetic biomineralized artificial bone in this example, hydrochloric acid was used as the acid solution, and CaCl was used as the calcium ion solution. 2 Aqueous solution, alkaline solution using NaOH aqueous solution, using glutaraldehyde for chemical crosslinking.
[0098] The mineralized collagen composite porous material was prepared according to steps S1-1 to S3-2 in Example 1, and then the mineralized collagen composite porous material was chemically crosslinked using glutaraldehyde, specifically, the mineralized collagen composite porous material obtained in step S3-2 was The mineralized collagen composite porous material was soaked in 0.05wt% glutaraldehyde in anhydrous ethanol solution for 48 hours for cross-linking; then the cross-linked mineralized collagen composite porous material was taken out, placed in a chromatography column, and purified by flowing pure Washing with water for 48 hours to remove the residual cross-linking ag...
Embodiment 3
[0100] In the preparation of the biomimetic biomineralized artificial bone in this embodiment, the acid solution adopts nitric acid aqueous solution, and the calcium ion solution adopts Ca(NO 3 ) 2 Aqueous solution, alkaline solution using KOH aqueous solution, using thermal dehydrogenation method for physical cross-linking.
[0101] The biomimetic biomineralized artificial bone was prepared according to the same steps as in Example 1, except that the acid solution in step S1-1 was replaced by 1000 mL of nitric acid aqueous solution with a concentration of 0.001 mol / L for hydrochloric acid solution, and the calcium ion solution in step S1-2 was replaced by 20 mL Concentration of 0.1mol / L Ca(NO 3 ) 2 Aqueous solution instead of CaCl 2 Aqueous solution, the alkaline aqueous solution in step S1-4 and step S2-3 replaces NaOH aqueous solution with the KOH aqueous solution of concentration 0.01mol / L, after step S3-2, use thermal dehydrogenation method to mineralized collagen comp...
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