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Heterogeneous scleral piece used for posterior scleral reinforcement and preparation method thereof

A technology of posterior sclera reinforcement and scleral lens, which is applied in the fields of tissue engineering and materials science, can solve the problems of slow development of posterior sclera reinforcement surgery, different quality standards of posterior sclera lens, and inability to be popularized and applied on a large scale, so that it is not easy to be distorted Flip, good compliance, appropriate hardness and elasticity

Active Publication Date: 2015-06-10
BEIJING MICROKPRO MEDICAL INSTR CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, restricted by the skill level of doctors and medical conditions, the quality standards of self-made posterior scleral lenses are different, and there are certain surgical risks. In addition, if the source of the corpse suffered from some serious diseases before death, it is not suitable to be used as a donor.
Due to the limitation of materials, the development of posterior scleral reinforcement surgery is slow, and it cannot be widely applied.

Method used

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  • Heterogeneous scleral piece used for posterior scleral reinforcement and preparation method thereof
  • Heterogeneous scleral piece used for posterior scleral reinforcement and preparation method thereof
  • Heterogeneous scleral piece used for posterior scleral reinforcement and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Preparation of heterogeneous sclera lens for posterior sclera reinforcement

[0031] 1 Materials and sources

[0032] The pericardium of slaughtered cattle is taken as the base material, and the cattle are quarantine-free and disease-free, and aseptic operation should be paid attention to in the process of material collection and transportation.

[0033] 2 Preparation of scleral lenses for posterior scleral reinforcement (see figure 1 )

[0034] 2.1 Base material pretreatment: remove impurities and excess parts (such as adipose tissue) on the pericardium, soak in distilled water, and disintegrate blood cells; then soak the base material in detergent chlorhexidine for 40 minutes to remove impurities and make Wool.

[0035] 2.2 Cutting and forming: Remove the part of the wool material with uneven thickness, elasticity, hardness and color after the treatment in 2.1, select the part with a thickness of 0.6-1mm, and cut or cut the wool material into shapes of di...

Embodiment 2

[0045] Example 2 Study on the biomechanical properties of the scleral lens after heterogeneous posterior sclera reinforcement

[0046] 1 Materials and preparation

[0047] The bovine pericardial patch, porcine pericardial patch and rabbit scleral patch were respectively used as base materials, and the corresponding posterior scleral patch was prepared according to the preparation process of Example 1.

[0048] 2. Biomechanical Research of Posterior Sclera Lenses of Different Materials In this example, the thickness of the posterior sclera was measured with a micro-thickness gauge to obtain the cross-sectional area of ​​the posterior sclera lens. The mechanical properties of the posterior scleral lens can be measured by applying different tensions to the posterior scleral lens with a universal tensile machine.

[0049]In the mechanical observation of animal experiments on bovine pericardium, pig pericardium, and rabbit sclera, rabbits were selected as the experimental objects....

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Abstract

The invention provides a heterogeneous scleral piece used for posterior scleral reinforcement and a preparation method thereof. According to the heterogeneous scleral piece, the base materials are wide in sources, the hardness and the elasticity are proper, the adaptability is good, the heterogeneous scleral piece is easy to implant and can be attached, sewn and fixed with a receptor scleral easily; after being implanted into a human body, the heterogeneous scleral piece is non-toxic, high in mechanical strength, good in histocompatibility, strong in anti-degradation capability, can not be calcified easily, and does not have rejection reaction, and scars can not be left; and due to the special shape design of the scleral piece, venae vorticosae can be prevented from being pressed and damaged, the sclearl piece can not be twisted and turned easily in the implanting and penetrating process, and can be left in the body for a long time, the complication caused by the frequency operations can be avoided, and the effect of treating the progressive myopia and the high myopia for a long time is achieved.

Description

technical field [0001] The invention relates to the fields of tissue engineering and material science, in particular to a heterogeneous sclera sheet for posterior sclera reinforcement and a preparation method thereof. Background technique [0002] Posterior scleral reinforcement surgery is a safe and effective method for the treatment of progressive myopia and high myopia. In previous clinical applications, the materials used in posterior sclera reinforcement surgery were mostly taken from the dura mater or sclera of the allogeneic cadaver, and were directly used in clinical surgery after simple treatment by ophthalmologists. However, restricted by the skill level of doctors and medical conditions, the quality standards of self-made posterior scleral lenses are different, and there are certain surgical risks. In addition, if the source of the corpse suffered from some serious diseases before death, it is not suitable as a donor. Due to the limitation of materials, the devel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/14A61L27/36
Inventor 于好勇
Owner BEIJING MICROKPRO MEDICAL INSTR CO LTD
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