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Freeze-drying powder injection of Bozhi glycopeptide and its preparation

A technology for freeze-dried powder injection and Bozhi glycopeptide, which is applied in the field of Bozhi glycopeptide injection and its preparation, can solve problems such as poor clarity, achieve excellent anti-degradation ability, stable quality, easy storage and transportation Effect

Active Publication Date: 2007-04-04
BEIJING SAISHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the above-mentioned technical problems existing in the prior art, the inventor has successfully developed Bozhi Glycopeptide freeze-dried powder injection, which has greatly improved the stability of the drug, and is relatively stable in storage at low temperature and higher temperature, and solves the problem of Solved the problem of poor clarity; and improved product yield, easy to transport and carry

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] The dry mycelium of Ganoderma Capense (Lloyd) Teng (provided by Beijing Saier Bio-Pharmaceutical Co., Ltd.) was prepared from the strain of Bo tree lucidum by liquid fermentation culture method, pulverized by a pulverizer, and passed through a 20-mesh sieve to obtain powder shaped mycelium.

[0069] According to the quality standard inspection of the dry mycelium of Bogus tree lucidum, the mycelium powder of the present invention meets the corresponding quality standard. The quality standards are as follows:

[0070] 1. Properties: This product is light brown and yellowish brown granular powder.

[0071] 2. Loss on drying: Take this product and dry it to constant weight at 105°C, and the weight loss should not exceed 8%.

[0072] 3. Toxicity and anti-nicotine effect inspection: Take 30 grams of dried mycelia, extract with 90% ethanol under reflux for 2 hours, filter while hot, then extract with ethanol under reflux for 3 times, combine the ethanol extracts, concentrat...

Embodiment 2

[0077] [Example 2] Preparation of Bozhi Glycopeptide Concentrate

[0078] Method 1: The dry mycelium of Ganoderma Capense (Lloyd) Teng obtained by the liquid fermentation culture method of Bo tree fungus strain is pulverized by a pulverizer and passed through a 20-mesh sieve to obtain powdery mycelium. Take 30g of mycelium powder, add 92-94% ethanol to reflux for 2 hours, and filter while hot. Then reflux extraction with ethanol for 3 times, combine the ethanol extracts, concentrate under reduced pressure on a water bath to a small volume, then add about 1 / 3 of the volume of water, and then concentrate under reduced pressure until the specific gravity of the distillate is 0 with an ethanol hydrometer. end. Let it cool down, add an appropriate amount of diethyl ether to extract about 10 times, discard the middle layer, and collect the ether layer and the water layer. Concentrate the water layer on a water bath to drive ether, which is the concentrated part of Bozhi injection....

Embodiment 3

[0080] [Example 3] Quality Standard of Bozhi Glycopeptide Concentrate

[0081] According to the quality standard inspection of Bozhi glycopeptide concentrate, the Bozhi glycopeptide concentrate of the present invention meets the corresponding quality standard. The quality standards are as follows:

[0082] This strain is the solution obtained by extracting the dry mycelia of Ganoderma Capense (Lloyd) Teng obtained by liquid fermentation culture method with Boshuzhi strain, and every milliliter of the solution contains polysaccharide and glucose (C 6 h 12 o 6 ) shall not be less than 2.5mg, and peptides shall not be less than 0.5mg.

[0083] 1. Properties: This product is a clear liquid from light yellow to light brown.

[0084] 2. Identification

[0085] (1) Take 1ml of this product, add 5ml of anthrone solution (take 0.2g of anthrone, add 100ml of sulfuric acid to dissolve; make it new before use), put it in a water bath, and the solution is blue-green.

[0086] (2) Tak...

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PUM

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Abstract

A freeze-dried powder injection of thin tree ganoderma's glycopeptide extracted from the thin tree ganoderma is proportionally prepared from said glycopeptide and the freeze-drying excipient.

Description

technical field [0001] The invention relates to a Bozhi glycopeptide preparation, in particular to a Bozhi glycopeptide injection preparation and a preparation method thereof. Background technique [0002] Ganoderma lucidum was first recorded as a medicine in "Shen Nong's Herbal Classic" in the Han Dynasty. Ancient medical scientists all believed that Ganoderma lucidum can treat many diseases, and it is a precious medicine that nourishes and strengthens the body and strengthens the body. Ganoderma lucidum is commonly known as Ganoderma lucidum, and there are folk legends such as "Ganoderma lucidum cures all diseases". Ganoderma lucidum is a precious medicinal fungus belonging to Basidiomycetes, Polyporaceae, Ganoderma genus. There are about 100 species in this genus, the common ones are Ganoderma lucidum, G. japonicum and G. capense. It was called "grass fairy" in ancient times. Ganoderma lucidum is a precious medicinal plant in the treasure house of traditional Chinese ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16A61K36/074A61K9/19A61P9/00A61P9/10A61P35/00A61P29/00
Inventor 马骉薛印革戴杰森宋梦薇
Owner BEIJING SAISHENG PHARMA
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