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Functional cellulose esterification based chemical cross-linking agent modified gelatin compound and preparation method and application thereof

A gelatin compound and chemical cross-linking agent technology, which is applied in the direction of non-active ingredients of polymer compounds, medical preparations containing active ingredients, digestive system, etc., can solve the problem of unfavorable drug loading, embedding, and tensile properties of the surface microscopic morphology. In order to achieve the effects of improving mechanical properties, prolonging life, and inhibiting in vitro degradation

Inactive Publication Date: 2016-06-22
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent CN104861078A discloses a gelatin film based on cellulose chemical crosslinking and its preparation method. Although the gelatin film in this patent has improved elasticity and flexibility, its tensile resistance is lower than that of the blank gelatin film. And its surface microscopic morphology is not conducive to the loading and embedding of drugs, which is very unfavorable for the application of drug carriers
In addition, the gelatin film has certain limitations in the anti-degradation utilization
Chinese patent CN105237645A discloses a macromolecular cross-linking agent based on oxidized cellulose, its gelatin film and its preparation method. Although the macromolecular cross-linking agent TMN in this patent does not need third-party molecules as a bridge, it realizes both gelatin and cellulose. direct connection of similar macromolecules, but the degree of cross-linking is low
[0006] But there is no application report about using modified gelatin complex as drug omeprazole carrier at present

Method used

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  • Functional cellulose esterification based chemical cross-linking agent modified gelatin compound and preparation method and application thereof
  • Functional cellulose esterification based chemical cross-linking agent modified gelatin compound and preparation method and application thereof
  • Functional cellulose esterification based chemical cross-linking agent modified gelatin compound and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Example 1: Preparation of gelatin complex modified based on functional cellulose ester chemical cross-linking agent and its application in loading drug omeprazole

[0074] (1) Synthesis of citric anhydride (CAD):

[0075] Weigh the corresponding mass of anhydrous citric acid (CA), acetic acid and acetic anhydride in a molar ratio of 1:2:1.2, and react at 35°C for 18h. After the reaction was over, the solvent acetic acid was distilled off under reduced pressure, and the residual oily product was added with 3 times the volume of chloroform of the reaction solution while stirring, and a large amount of white solids were precipitated. Suction filter and wash with chloroform, dry to obtain citric anhydride (CAD).

[0076] (2) Preparation of CAD functionalized microcrystalline cellulose (MC):

[0077] Weigh 1 g of microcrystalline cellulose (MCC) and 6 g of CAD in 50 ml of DMF, stir magnetically in an oil bath at 70°C for 24 h, wash with 10 ml of DMF, 150 ml of distilled wa...

Embodiment 2

[0108] Example 2: Preparation of gelatin complex modified based on functional cellulose ester chemical cross-linking agent and its application in loading drug omeprazole

[0109] (1) Synthesis of citric anhydride (CAD):

[0110] Weigh corresponding masses of anhydrous citric acid (CA), acetic acid and acetic anhydride in a molar ratio of 1:2:1.5, and react at 37°C for 18h. After the reaction was over, the solvent acetic acid was distilled off under reduced pressure, and chloroform of 4 times the volume of the reaction solution was added to the residual oil under stirring conditions, and a large amount of white solids were precipitated. Suction filter and wash with chloroform, dry to obtain citric anhydride (CAD).

[0111] (2) Preparation of CAD functionalized microcrystalline cellulose (MC):

[0112] Weigh 1 g of microcrystalline cellulose (MCC) and 5 g of CAD in 40 ml of DMF, stir magnetically in an oil bath at 65 °C for 20 h, wash with 10 ml of DMF, 100 ml of distilled wat...

Embodiment 3

[0122] Example 3: Preparation of gelatin complex modified based on functional cellulose ester chemical cross-linking agent and its application in loading drug omeprazole

[0123] (1) Synthesis of citric anhydride (CAD):

[0124] Weigh corresponding masses of anhydrous citric acid (CA), acetic acid and acetic anhydride at a molar ratio of 1:2:1.8, and react at 40°C for 16h. After the reaction, the solvent acetic acid was distilled off under reduced pressure, and the residual oily product was added with 5 times the volume of the reaction solution of chloroform under stirring conditions, and a large amount of white solids were precipitated. Suction filter and wash with chloroform, dry to obtain citric anhydride (CAD).

[0125] (2) Preparation of CAD functionalized microcrystalline cellulose (MC):

[0126] Weigh 1g of microcrystalline cellulose (MCC) and 8g of CAD in 60ml of DMF, stir magnetically in an oil bath at 72°C for 22 hours, wash with 15ml of DMF, 150ml of distilled wat...

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Abstract

The invention discloses a functional cellulose esterification based chemical cross-linking agent modified gelatin compound with the constitutional unit shown as formula I (n=200-500) below. The invention further discloses a preparation method of the modified gelatin compound, and the modified gelatin compound is obtained by amidation of a macromolecular cross-linking agent and gelatin. Heat stability, biodegradability resistance, mechanical property and surface hydrophobicity of the cross-linking agent modified gelatin compound are remarkably improved; particularly, a freeze dried composite gelatin network is remarkably improved, and honeycomb-cell-shaped surface microtopography provides a dwelling location for loading and embedding of drugs, so that favorable conditions are provided for application of the gelatin compound as drug carriers.

Description

technical field [0001] The invention belongs to the technical field of gelatin modification, and in particular relates to a gelatin compound modified based on a functional cellulose ester chemical crosslinking agent and a preparation method and application thereof. Background technique [0002] Gelatin is a kind of natural protein obtained by alkaline or acidic hydrolysis of collagen. It is widely used in biological materials etc. However, its low thermal stability, poor mechanical properties, and easy degradation limit its application, so gelatin is often modified. [0003] Microcrystalline cellulose (MCC) is a renewable resource with a wide range of sources. Its good compatibility with living cells and non-toxicity make it often blended with gelatin or optimized by reacting with gelatin with a third-party cross-linking agent. The nature of gelatin, and then meet the requirements of the medical field. Such as Ooi prepared a kind of glutaraldehyde crosslinked gelatin / cell...

Claims

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Application Information

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IPC IPC(8): C08G81/00C08B15/06C08B3/12A61K47/42A61K31/4439A61P1/04
CPCA61K31/4439A61K47/42C08B3/12C08B15/06C08G81/00
Inventor 陶芙蓉庄辰崔月芝李俊英
Owner QILU UNIV OF TECH
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