Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Gelatin composite modified based on functional cellulose ester chemical cross-linking agent and its preparation method and application

A gelatin compound and chemical cross-linking agent technology, which is applied in the direction of non-active ingredients of polymer compounds, digestive system, drug combination, etc., can solve the problems of unfavorable drug loading and embedding, reduced stretch resistance, and unfavorable surface microscopic appearance. There are application reports and other issues to achieve the effects of improving mechanical properties, prolonging life, and inhibiting degradation in vitro

Inactive Publication Date: 2018-04-27
QILU UNIV OF TECH
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent CN104861078A discloses a gelatin film based on cellulose chemical crosslinking and its preparation method. Although the gelatin film in this patent has improved elasticity and flexibility, its tensile resistance is lower than that of the blank gelatin film. And its surface microscopic morphology is not conducive to the loading and embedding of drugs, which is very unfavorable for the application of drug carriers
In addition, the gelatin film has certain limitations in the anti-degradation utilization
Chinese patent CN105237645A discloses a macromolecular cross-linking agent based on oxidized cellulose, its gelatin film and its preparation method. Although the macromolecular cross-linking agent TMN in this patent does not need third-party molecules as a bridge, it realizes both gelatin and cellulose. direct connection of similar macromolecules, but the degree of cross-linking is low
[0006] But there is no application report about using modified gelatin complex as drug omeprazole carrier at present

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Gelatin composite modified based on functional cellulose ester chemical cross-linking agent and its preparation method and application
  • Gelatin composite modified based on functional cellulose ester chemical cross-linking agent and its preparation method and application
  • Gelatin composite modified based on functional cellulose ester chemical cross-linking agent and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Example 1: Preparation of gelatin complex modified based on functional cellulose ester chemical cross-linking agent and its application in loading drug omeprazole

[0074] (1) Synthesis of citric anhydride (CAD):

[0075] Weigh the corresponding mass of anhydrous citric acid (CA), acetic acid and acetic anhydride in a molar ratio of 1:2:1.2, and react at 35°C for 18h. After the reaction was over, the solvent acetic acid was distilled off under reduced pressure, and the residual oily product was added with 3 times the volume of chloroform of the reaction solution while stirring, and a large amount of white solids were precipitated. Suction filter and wash with chloroform, dry to obtain citric anhydride (CAD).

[0076] (2) Preparation of CAD functionalized microcrystalline cellulose (MC):

[0077] Weigh 1 g of microcrystalline cellulose (MCC) and 6 g of CAD in 50 ml of DMF, and stir magnetically in an oil bath at 70°C for 24 hours. filtered, and vacuum-dried at 50°C to...

Embodiment 2

[0108] Example 2: Preparation of gelatin complex modified based on functional cellulose ester chemical cross-linking agent and its application in loading drug omeprazole

[0109] (1) Synthesis of citric anhydride (CAD):

[0110] Weigh corresponding masses of anhydrous citric acid (CA), acetic acid and acetic anhydride in a molar ratio of 1:2:1.5, and react at 37°C for 18h. After the reaction was over, the solvent acetic acid was distilled off under reduced pressure, and chloroform of 4 times the volume of the reaction solution was added to the residual oil under stirring conditions, and a large amount of white solids were precipitated. Suction filter and wash with chloroform, dry to obtain citric anhydride (CAD).

[0111] (2) Preparation of CAD functionalized microcrystalline cellulose (MC):

[0112] Weigh 1 g of microcrystalline cellulose (MCC) and 5 g of CAD in 40 ml of DMF, and stir magnetically in an oil bath at 65 °C for 20 h. filtered, and vacuum-dried at 50°C to obta...

Embodiment 3

[0122] Example 3: Preparation of gelatin complex modified based on functional cellulose ester chemical cross-linking agent and its application in loading drug omeprazole

[0123] (1) Synthesis of citric anhydride (CAD):

[0124] Weigh corresponding masses of anhydrous citric acid (CA), acetic acid and acetic anhydride at a molar ratio of 1:2:1.8, and react at 40°C for 16h. After the reaction, the solvent acetic acid was distilled off under reduced pressure, and the residual oily product was added with 5 times the volume of the reaction solution of chloroform under stirring conditions, and a large amount of white solids were precipitated. Suction filter and wash with chloroform, dry to obtain citric anhydride (CAD).

[0125] (2) Preparation of CAD functionalized microcrystalline cellulose (MC):

[0126] Weigh 1 g of microcrystalline cellulose (MCC) and 8 g of CAD in 60 ml of DMF, and stir magnetically in an oil bath at 72°C for 22 hours. filtered, and vacuum-dried at 50°C to...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a functional cellulose esterification based chemical cross-linking agent modified gelatin compound with the constitutional unit shown as formula I (n=200-500) below. The invention further discloses a preparation method of the modified gelatin compound, and the modified gelatin compound is obtained by amidation of a macromolecular cross-linking agent and gelatin. Heat stability, biodegradability resistance, mechanical property and surface hydrophobicity of the cross-linking agent modified gelatin compound are remarkably improved; particularly, a freeze dried composite gelatin network is remarkably improved, and honeycomb-cell-shaped surface microtopography provides a dwelling location for loading and embedding of drugs, so that favorable conditions are provided for application of the gelatin compound as drug carriers.

Description

technical field [0001] The invention belongs to the technical field of gelatin modification, and in particular relates to a gelatin compound modified based on a functional cellulose ester chemical crosslinking agent, a preparation method and application thereof. Background technique [0002] Gelatin is a kind of natural protein obtained by alkaline or acidic hydrolysis of collagen. It is widely used in biological materials etc. However, its low thermal stability, poor mechanical properties, and easy degradation limit its application, so gelatin is often modified. [0003] Microcrystalline cellulose (MCC) is a renewable resource with a wide range of sources. Its good compatibility with living cells and non-toxicity make it often blended with gelatin or optimized by reacting with gelatin with a third-party cross-linking agent. The nature of gelatin, and then meet the requirements of the medical field. For example, Ooi prepared a glutaraldehyde-crosslinked gelatin / cellulose ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08G81/00C08B15/06C08B3/12A61K47/42A61K31/4439A61P1/04
CPCA61K31/4439A61K47/42C08B3/12C08B15/06C08G81/00
Inventor 陶芙蓉庄辰崔月芝李俊英
Owner QILU UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com