Antigen-free porcine dermal collagen fibers

Abstract

The invention discloses antigen-free porcine dermal collagen fibers and a preparation method thereof. The antigen-free porcine dermal collagen fibers with excellent performance and wide application are prepared by using purified porcine skin as a raw material and adopting a method of combining physics, chemistry and biochemistry to perform a series of treatment such as fluffing, fiber decomposition, fiber separation, carding and the like on the purified porcine skin on the premise of ensuring good mechanical property of the purified porcine skin unchangeable. The antigen-free porcine dermal collagen fibers have good biocompatibility, good mechanical property and proper degradability, and can be widely applied to preparation of medicinal biological materials such as tissue engineering scaffold materials, hemostatic materials, medicinal operation stitches and the like.

Description

Technical field [0001] The invention relates to antigen-free pig dermal collagen fibers and a preparation method thereof, and belongs to the field of biomedical materials. Background technique [0002] So far, as far as the world is concerned, whether it is organ transplantation or tissue defect repair, there are serious shortages of allogeneic organs or tissue donors, and negative effects such as rejection caused by allogeneic organ or tissue transplantation. The rise and rapid development of tissue engineering have brought hope to organ transplantation and repair and reconstruction of soft and hard tissues. Tissue engineering materials, especially the research and development of tissue engineering scaffold materials, have become and will continue to be one of the research hotspots and focuses of international biomaterials. [0003] Collagen has good biocompatibility, weak antigenicity, excellent hydrophilicity and unique porous structure. It is a rare ideal biomaterial. The app...

AI Technical Summary

Problems solved by technology

[0006] 1. There is still the problem that the pore structure is not suitable for the three-dimensional growth of cells in the preparation of tissue engineering scaffold materials by using acellular porcine dermal matrix materials;

[0007] 2. Using the hydrolyzate of pigskin to compound with other natural / synthetic polymer materials to prepare biomedical membrane materials, the mechanical properties are poor, and the pore structure is not suitable for the three-dimensional growth of cells;

[0008] 3. Composite medical fibers based on pigskin collagen have problems such as poor mechanical properties and unstable biocompatibility