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Medical ti-based composite coating with bone repair function and antibacterial performance and preparing method of coating

A composite coating and titanium-based technology, applied in the field of medical materials, can solve problems such as insufficient bone repair ability, poor antibacterial properties, limited vascularization of implants and surrounding tissues, etc., to solve the problems of osseointegration ability and antibacterial performance Good antibacterial ability, the effect of improving osseointegration performance

Active Publication Date: 2017-10-31
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The present invention aims at technical problems such as the lack of bone repair ability of titanium-based implants used in clinical practice, the limited integration between implants and surrounding tissues and the formation of blood vessels, and the secondary surgery caused by poor antibacterial properties. The purpose of the present invention is to provide a titanium surface Modification method to meet the requirements of bone repair performance and antibacterial performance required for medical titanium materials

Method used

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  • Medical ti-based composite coating with bone repair function and antibacterial performance and preparing method of coating
  • Medical ti-based composite coating with bone repair function and antibacterial performance and preparing method of coating
  • Medical ti-based composite coating with bone repair function and antibacterial performance and preparing method of coating

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Comparison scheme
Effect test

Embodiment 1

[0037] After the pure titanium sheet of 10mm×10mm×1mm is polished, it is ultrasonically cleaned with acetone, absolute ethanol and deionized water in sequence, each time for 10 minutes. Using plasma immersion ion implantation / plating technology, zinc and copper are implanted into the titanium substrate in the form of zinc-copper co-injection (Zn+Cu-PIII), and the ion implantation depth in the obtained titanium-based composite coating is 0-70nm. The atomic percentage of zinc on the titanium surface is 9.78%, and the atomic percentage of copper is 2.56%. Its concrete process parameter is shown in Table 1:

[0038] Table 1 Zinc / copper binary ion implantation parameters

[0039] Injection voltage (kV)

15

High voltage pulse width (μs)

500

Co-injection time of zinc and copper (minutes)

60

Pulse arc pulse width (μs)

800

Frequency (Hz)

5

Vacuum

5.0×10 -3

[0040] figure 1 It is a comparison diagram of the scanning electro...

Embodiment 2

[0043] After the pure titanium sheet of 10mm×10mm×1mm is polished, it is ultrasonically cleaned with acetone, absolute ethanol and deionized water in sequence, each time for 10 minutes. Using plasma immersion ion implantation / plating technology, zinc and copper are implanted into the titanium substrate in the form of zinc-copper co-injection (Zn+Cu-PIII), and the ion implantation depth in the obtained titanium-based composite coating is 0-70nm. The atomic percent of zinc on the titanium surface is 0.91%, and the atomic percent of copper is 0.04%. Its concrete process parameter is shown in Table 2:

[0044] Table 2 Zinc / copper binary ion implantation parameters

[0045]

[0046]

Embodiment 3

[0048] After the pure titanium sheet of 10mm×10mm×1mm is polished, it is ultrasonically cleaned with acetone, absolute ethanol and deionized water in sequence, each time for 10 minutes. Using plasma immersion ion implantation / coating technology, zinc and copper are implanted into the titanium substrate in the way of co-injection of copper first and then zinc (Zn+Cu-PIII), and the ion implantation depth in the obtained titanium-based composite coating is 0-100nm. The atomic percentage of zinc on the titanium surface is 26.33%, and the atomic percentage of copper is 0.01%. Its concrete process parameter is shown in Table 2:

[0049] Table 3 Zinc / copper binary ion implantation parameters

[0050] Copper injection voltage (kV)

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Abstract

The invention relates to a medical ti-based composite coating with a bone repair function and antibacterial performance and a preparing method of the coating. The medical ti-based composite coating is a copper zinc ion implantation layer formed in a manner that zinc / copper binary ions are injected into the surface of a medical ti-based material, in the medical ti-based composite coating, the zinc exists in a manner of a zinc compound and / or metal zinc and / or zinc alloy, and copper exists in a manner of a copper compound and / or metal copper and / or copper alloy. Cell compatibility and molecular biology experiment results show that a ti-based material obtained through modification has the obvious promotion effect on increasing of related bone-formation cells, and expression of bone and blood forming related genes can be obviously improved.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a surface modification method for implanting medical titanium materials with zinc / copper binary ions. Background technique [0002] Titanium (Ti) and its alloys have the characteristics of low elastic modulus, strong mechanical properties, corrosion resistance and good biocompatibility, and are ideal for hard tissue implants (such as artificial joints, bone trauma products, spinal orthopedic internal fixation systems and material of choice for dental implants, etc.). However, the average lifespan of titanium alloy implants at this stage is 10-15 years, which is still far from meeting the requirements of patients. Long-term clinical follow-up and research findings: (1) Poor bone regeneration ability and poor integration with surrounding tissues; (2) The lack of durable antibacterial properties on the surface can easily lead to postoperative bacterial infecti...

Claims

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Application Information

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IPC IPC(8): C23C14/48C23C14/16A61L27/06A61L27/30A61L27/54
CPCA61L27/06A61L27/306A61L27/54A61L2300/102A61L2300/404A61L2400/18A61L2420/06A61L2430/02C23C14/16C23C14/48
Inventor 乔玉琴刘宣勇
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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