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Application of vaccarin in treating open skin lesions

A technology of blanculin glycosides and skin damage, which is applied in the field of blaliculine glycosides to achieve the effect of promoting healing

Inactive Publication Date: 2015-12-23
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] After investigation, there is no relevant literature report on the effect of flavonoid glycosides of blancalique on the treatment of open skin lesions (from CNKI, VIP China Journal Network), so the pharmacological and pharmacological effects of flavonoid glycosides of blancalique on the treatment of open skin lesions have not been found. Equivalent research field is still in the blank stage

Method used

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  • Application of vaccarin in treating open skin lesions
  • Application of vaccarin in treating open skin lesions
  • Application of vaccarin in treating open skin lesions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Example 1: Preparation of Wangbuliuxing flavonoid glycoside ointment

[0009] Accurately weigh 2 g of petroleum jelly with an electronic analytical balance, accurately measure 500 μl of pure glycerin with a pipette, and mix evenly in a small beaker with a medicine spoon in the same direction to obtain a matrix ointment. Accurately weigh 0.6 mg of flavonoid glycosides and 2 g of vaseline with an electronic analytical balance, accurately measure 500 μl of glycerin with a pipette, and mix evenly in a small beaker with a medicine spoon in the same direction to obtain a medicated ointment.

Embodiment 2

[0010] Example 2: Buliuxing flavonoid glycosides can promote healing against open injuries

[0011] Select 6-8 week-old male ICR mice with a body weight of 25±2g, and randomly divide them into two groups with 8 mice in each group. The animals are purchased one week before the start of the experiment. Intraperitoneal anesthesia was performed with 1% sodium pentobarbital at a dose of 50 mg / kg. After anesthesia, fix the limbs of the mouse with medical adhesive tape, shave off the back hair, disinfect with 75% ethanol, lift the skin with curved forceps, and remove the full thickness of the back skin with ophthalmological scissors on the back of the mouse, reaching deep to the fascia, with a circular wound size and diameter 0.5cm, causing full-thickness skin damage to the dermis and epidermis, and exposing the wound. The mice were reared conventionally and did not receive brake treatment. The mice were fully awake within 2 hours, and their physiological state was normal, indicatin...

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Abstract

The invention discloses application of vaccarin in treating open skin lesions, and belongs to the technical field of application of a traditional Chinese medicine. The invention discovers firstly the activity of the vaccarin in promoting healing of open skin lesions, and the vaccarin is applicable to a series of diseases including diabetic foot, ulcer, tetanus, infection, rash, pathological scars, body's malnutrition, tissue necrosis, metabolism imbalance and the like related to the open skin lesions. The vaccarin is applicable to pharmaceutical preparations, cosmetics and the like.

Description

Technical field: [0001] The application of the flavonoid glycoside of wangbuliuxing for treating open skin injury belongs to the technical field of traditional Chinese medicine application. The present invention relates to the flavonoid glycosides with the activity of treating open skin lesions, and clarifies its new application in medicine and cosmetics. Background technique: [0002] Wangbuliu is the dry mature seed of Vaccariasegetalis (Neck.) Garcke, a plant of Caryophyllaceae. Buliuxing mainly contains triterpenoid saponins, flavonoid glycosides, cyclic peptides, lipids, fatty acids, and monosaccharides. Among them, the flavonoid glycoside of wangbuliuxing has been included in the Pharmacopoeia. It is a flavonoid triglycoside extracted from wangbuliuxing. It is a light yellow granular crystal and is easily soluble in methanol, methanol-water, ethanol, and ethanol-water. , n-butanol, etc., insoluble in chloroform, ethyl acetate, petroleum ether, etc. It is reported th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K8/37A61Q19/00A61P17/00
Inventor 邱丽颖刘艳玲杜斌冯磊王旭蔡维维谢凤珊李曰侯豹赵霞赵庆顾蓉
Owner JIANGNAN UNIV
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