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Antibacterial hydrogel suitable for diabetic foot ulcer and preparation method thereof

A technology for diabetic foot ulcers and hydrogels, which is applied in the directions of antibacterial drugs, topical antibacterial agents, medical preparations with inactive ingredients, etc. It can improve the healing speed, promote the regeneration of cells, and promote the healing effect.

Inactive Publication Date: 2021-01-29
XIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the antibacterial hydrogel has excellent antibacterial properties, it is slow to absorb wound exudate, and does not contain active pharmaceutical ingredients, so its ability to promote skin cell regeneration is limited

Method used

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  • Antibacterial hydrogel suitable for diabetic foot ulcer and preparation method thereof
  • Antibacterial hydrogel suitable for diabetic foot ulcer and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] A preparation method for an antibacterial hydrogel suitable for diabetic foot ulcers, comprising the following steps:

[0025] (1) Advance preparation of the active ingredient D of the drug: pulverize frankincense, angelica, phellodendron, and cuttlefish bone, mix them in a mass ratio of 1:2:1:1, and soak them in ethanol with a volume fraction of 65% for 60 minutes. The ratio of solid to liquid is 1:3, then vacuum-packed and placed in ultra-high pressure equipment, set the pressure at 200MPa, and the temperature at 80°C, collect the extract after 10 minutes of extraction, repeat the extraction of the filter residue twice, mix all the extracts and filter, and collect the filtrate , to obtain the alcoholic extracts of frankincense, angelica, cortex, cuttlefish bone.

[0026] (2) Sodium alginate was dissolved in deionized water, stirred evenly to prepare a sodium alginate solution with a mass fraction of 1%, and acrylic acid was added to the sodium alginate solution, and t...

Embodiment 2

[0030] A preparation method for an antibacterial hydrogel suitable for diabetic foot ulcers, comprising the following steps:

[0031] (1) Advance preparation of the active ingredient D of the drug: pulverize frankincense, angelica, phellodendron, and cuttlefish bone, mix them in a mass ratio of 1:2:1:1, and soak them in ethanol with a volume fraction of 65% for 60 minutes. The ratio of solid to liquid is 1:3, then vacuum-packed and placed in ultra-high pressure equipment, set the pressure at 200MPa, and the temperature at 80°C, collect the extract after 10 minutes of extraction, repeat the extraction of the filter residue twice, mix all the extracts and filter, and collect the filtrate , to obtain the alcoholic extracts of frankincense, angelica, cortex, cuttlefish bone.

[0032](2) Sodium alginate was dissolved in deionized water, stirred evenly to prepare a sodium alginate solution with a mass fraction of 1%, and acrylic acid was added to the sodium alginate solution, and th...

Embodiment 3

[0036] A preparation method for an antibacterial hydrogel suitable for diabetic foot ulcers, comprising the following steps:

[0037] (1) Advance preparation of the active ingredient D of the drug: pulverize frankincense, angelica, cortex cortex, and cuttlefish bone, mix them in a mass ratio of 1:2:1:1, and soak them in ethanol with a volume fraction of 68% for 45 minutes. The ratio of solid to liquid is 1:3, then vacuum-packed and placed in ultra-high pressure equipment, set the pressure at 300MPa, and the temperature at 70°C, collect the extract after 8 minutes of extraction, repeat the extraction of the filter residue twice, mix all the extracts and filter, and collect the filtrate , to obtain the alcoholic extracts of frankincense, angelica, cortex, cuttlefish bone.

[0038] (2) Sodium alginate was dissolved in deionized water, stirred evenly to prepare a sodium alginate solution with a mass fraction of 2%, and acrylic acid was added to the sodium alginate solution, and th...

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Abstract

The invention provides antibacterial hydrogel suitable for diabetic foot ulcer and a preparation method of the antibacterial hydrogel, and belongs to the technical field of preparation of medical hydrogel. The preparation method comprises the following steps: (1) adding acrylic acid, a cross-linking agent and an initiator solution into a sodium alginate solution, and carrying out sodium alginate modification; (2) adding a medicinal active component D and an antibacterial component E, and adding a CaCl2 solution to prepare a crude gel product; and (3) washing the coarse gel, and sucking the washed coarse gel with filter paper to obtain the antibacterial hydrogel. According to the prepared hydrogel, by improving sodium alginate, the wound exudate absorption speed can be greatly increased, the wound is treated in time, traditional Chinese medicine ingredients are added, the hydrogel permeates into the wound through slow release to be absorbed by a human body, the local medication effect is achieved, and the blood supply condition of the ulcer position can be improved through addition of the conyzasaponin R, so that the healing speed of the diabetic foot ulcer is increased through a synergistic effect.

Description

technical field [0001] The invention relates to the technical field of medical hydrogel preparation, in particular to an antibacterial hydrogel suitable for diabetic foot ulcers and a preparation method thereof. Background technique [0002] Diabetic foot chronic ulcer is one of the common clinical diseases and the main cause of diabetes disability. Due to metabolic disorders, impaired immune function, slow nerve response and other reasons in diabetic patients, chronic diabetic foot ulcers are often difficult to heal on their own, and the course of the disease is long, which not only brings pain to patients, but also brings heavy economic burden and nursing care to their families. Pressure, therefore, the occurrence and treatment of chronic diabetic foot ulcers is a growing social problem. For diabetic foot chronic ulcers, in addition to the general etiological treatment according to the patient's condition, in view of the common surgical contraindications in diabetic patie...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61K9/06A61K47/36A61P17/02A61P29/00A61P31/02A61P31/04A61K31/704A61K31/785A61K35/618
CPCA61K9/0014A61K9/06A61K31/704A61K31/785A61K35/618A61K36/232A61K36/324A61K36/756A61K47/36A61P17/02A61P29/00A61P31/02A61P31/04A61K2300/00
Inventor 梁飞苟兴春姚琳余丽丽李伟泽
Owner XIAN MEDICAL UNIV
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