Fly larva protein preparation and application thereof

A fly maggot protein and preparation technology, applied in the field of medicine, can solve problems such as unsatisfactory effect and drug resistance

Inactive Publication Date: 2014-12-03
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of diabetic foot ulcers mainly focuses on improving microcirculation and anti-inflammation, but the effects are not ideal. The reason is that most of these drugs are administered orally, and after absorption and distribution, they can reach the nerves. The amount of drug at the end is already negligible; on the other hand, it is also due to the use of a large number of antibiotics that are prone to drug resistance

Method used

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  • Fly larva protein preparation and application thereof
  • Fly larva protein preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: Preparation of fly maggot protein gel

[0015] Fly maggot protein powder (purity 80%) 10g glycerin 100g PEG-4000 80g

[0016] Cross-linked sodium polyacrylate (400) 20g Benzalkonium bromide 10ml

[0017] Distilled water up to 1000g

[0018] Preparation: Weigh PEG-400, heat glycerin in a beaker until completely dissolved, add fly maggot protein and mix well, add cross-linked sodium polyacrylate to 700ml water and grind in a mortar, then mix with PEG-400, glycerin, fly maggot Mix protein, add water to 1000g, that is.

Embodiment 2

[0019] Embodiment 2: Preparation of fly maggot protein gel

[0020] Fly maggot protein powder (purity 80%) 20g glycerin 120g PEG-4000 100g

[0021] Cross-linked sodium polyacrylate (400) 30g Benzalkonium bromide 10ml

[0022] Distilled water up to 1000g

[0023] Preparation: Weigh PEG-400, heat glycerin in a beaker until completely dissolved, add fly maggot protein and mix well, add cross-linked sodium polyacrylate to 700ml water and grind in a mortar, then mix with PEG-400, glycerin, fly maggot Mix protein, add water to 1000g, that is.

Embodiment 3

[0024] Embodiment 3: the preparation of fly maggot protein gel

[0025] Fly maggot protein powder (purity 60%) 50g glycerin 160g PEG-4000 120g

[0026] Cross-linked sodium polyacrylate (400) 40g Benzalkonium bromide 10ml

[0027] Distilled water up to 1000g

[0028] Preparation: Weigh PEG-400, heat glycerin in a beaker until completely dissolved, add fly maggot protein and mix well, add cross-linked sodium polyacrylate 500ml water and grind in a mortar, then mix with PEG-400, glycerin, fly maggot Mix protein, add water to 1000g, that is.

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Abstract

The invention discloses a fly larva protein preparation which comprises fly larva protein and a pharmaceutically acceptable carrier or excipient, wherein the specific gravity of the fly larva protein is not less than 1% of the total amount of drugs, and the purity of the fly larva protein is not less than 50%. The fly larva protein preparation has very good antibacterial and healing-promotion effects, is relatively low in cost, relatively small in side effect and less in possibility of generating drug resistance, and can be used for preparing medicaments for treating burn injury, scald injury and diabetic foot ulcer.

Description

technical field [0001] The invention relates to a fly maggot protein preparation, which belongs to the technical field of medicine. Background technique [0002] Millions of people in my country suffer from disability and death caused by burns and scalds every year. The most important thing to treat burns (scalds) is to avoid bacterial infection on the wound surface. At present, antibiotics are mainly used to achieve the purpose of anti-inflammation and antibacterial. However, due to the extensive use of antibiotics, severe infection wounds caused by drug-resistant bacteria are gradually increasing, and there is a lack of effective therapeutic drugs in clinical practice. Therefore, the development and application of new antibacterial and anti-inflammatory drugs is one of the effective methods for the treatment of burns (scalds). [0003] Another multiple disease - diabetes, 15% to 20% of its patients are prone to foot ulcers, called diabetic foot, mainly manifested as foot ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/02A61P17/02A61P31/04A61K35/64
Inventor 奚苗苗郭超王寿宇殷英段佳林翁琰戴福清关月朱艳荣卫国王艳华
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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