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Preparation method of bioactive medical dressing

A bioactive, high molecular polymer technology, applied in the field of preparation of bioactive medical dressings, can solve the problems of a large number of post-processing, complex preparation process, low production efficiency, etc., and achieve the effect of stable product, simple process and high production efficiency

Active Publication Date: 2021-08-13
WUYI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation process of three-dimensional medical dressings in the prior art is relatively complicated, requiring a lot of post-processing, and the production efficiency is low

Method used

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  • Preparation method of bioactive medical dressing
  • Preparation method of bioactive medical dressing
  • Preparation method of bioactive medical dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] This embodiment has prepared a kind of bioactive medical dressing, and specific process comprises:

[0048] Step 1, the preparation of aqueous solution

[0049] (1) Preparation of sodium alginate aqueous solution (NaA), gelatin aqueous solution (Gel) and chitosan aqueous solution (CS): sodium alginate powder and deionized water are mixed to prepare a certain concentration (preferably about 2wt%, in this implementation Example is 2wt% sodium alginate aqueous solution; gelatin powder and deionized water are mixed to prepare a certain concentration (preferably about 1wt%, the present embodiment is 1wt%) gelatin aqueous solution; chitosan powder and 1% (v / v) acetic acid is mixed, is prepared into the chitosan aqueous solution of certain concentration (preferably about 1wt%, the present embodiment is 1wt%);

[0050] (2) Platelet-rich plasma (PRP): 40 ml of blood was collected from the abdominal aorta of 10 rats, injected into a centrifuge tube containing 0.5 mmol / L EDTAK2 a...

Embodiment 2

[0058] This embodiment prepares a bioactive medical dressing, the difference from Example 1 is that in step 2, the two-channel coaxial nozzle is replaced with a three-channel coaxial nozzle with a specification of 14G / 18G / 25G (such as figure 1 a, c and c1, c2 shown). The inlet ports of the inner, middle and outer phase channels of the three-channel coaxial nozzle are respectively connected with polyethylene plastic tube ends, and the polyethylene plastic tube ends are respectively connected with the needles of the three syringes. The inner phase of the three-channel coaxial nozzle was injected with a mixed aqueous solution of gelatin (Gel) and platelet-rich plasma (PRP), the middle phase was injected with sodium alginate (NaA), and the outer phase was injected with chitosan aqueous solution (CS). like Figure 7 As shown in the blue area (in the figure, black area: cannot be spun and cannot be printed, light blue: can only be spun but not 3D printed; blue: can be spun but can ...

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Abstract

The invention discloses a preparation method of a bioactive medical dressing. The method comprises the following steps of S1, taking raw material solutions for later use, and performing printing through a microfluidic 3D printing assembly; and S2, introducing contents into all channels in a multi-channel coaxial jet head, controlling the flow speed, setting parameters of a 3D printer, and using the 3D printer to control a micro-fluidic chip to print the three-dimensional diabetic foot ulcer functional medical dressing, wherein the raw material solutions comprise an alginate solution, a first high-molecular polymer solution, a bioactive component solution and a second high-molecular polymer solution. According to the method, the process is simple, subsequent treatment of the dressing is not needed, the production efficiency is high, the cost is low, the product is stable, the precision is high, and the experimental repeatability is high.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a preparation method of a bioactive medical dressing. Background technique [0002] The skin is an important organ of the human body. It has very important physical, chemical and biological barrier functions. It plays a role in preventing the loss of water and electrolytes and other substances, as well as immune and sensing functions. It plays a role in maintaining the stability of the internal environment and preventing microbial invasion. very important role. Skin damage caused by trauma, burns, and skin ulcers will cause a series of problems in the body, such as bacterial infection, increased metabolism, excessive loss of water and protein, endocrine and immune system dysfunction, etc., which may be life-threatening in severe cases. Therefore, after skin injury, it is usually necessary to use a skin substitute medical dressing to protect the wound, prevent wound inf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C64/209B29C64/112B29C64/20B29C64/393B33Y30/00B33Y10/00B33Y50/02
CPCB29C64/209B29C64/112B29C64/20B29C64/393B33Y30/00B33Y10/00B33Y50/02
Inventor 于晖黄琪帏吴廷斌
Owner WUYI UNIV
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