Pharmaceutical composition for treating diabetic foot ulcer and use method thereof

Abstract

The invention discloses a pharmaceutical composition for treating diabetic foot ulcer in the technical field of medicine, the pharmaceutical composition comprises loropetalum chinense extract, angelica sinensis extract, liquorice extract, angelica dahurica extract and lithospermum erythrorhizon extract, and the application dosage form of the pharmaceutical composition is gel. A hydrogel carrier of the gel is antibacterial hydrogel which is formed by PDLA-CPC-PDLA and PLLA-PEG-PLLA through complexation, and the antibacterial hydrogel is adhered to an application capable of being heated by self; the antibacterial hydrogel is fixed on the surface of a wound through the application, the medicine is separated out from the hydrogel by utilizing the temperature difference between a patient and the application, and the medicine is accumulated on the surface of the wound, so that the absorption of the medicine by the wound is facilitated, and the healing process of the wound is accelerated.

Description

Technical Field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating diabetic foot ulcers. Background Art

[0002] Diabetic foot ulcer is one of the common late complications of diabetes, with high disability and mortality rates. The pathogenesis of diabetic foot ulcer is mainly related to infection factors, neuropathy and vascular disease. The existing treatment of diabetic foot ulcer mainly focuses on controlling blood sugar, anti-infection, ulcer debridement, and promoting tissue regeneration.

[0003] Chronic wounds of diabetic foot patients generally stay in the inflammatory stage for a long time, and during this process are accompanied by large amounts of tissue exudate, severe infection, pain, local tissue necrosis, etc. These wounds often involve infection with pathogenic microorganisms and require long-term medication and dressing changes, which brings serious physical, psychological and economic burdens to patients and reduces their quality of life.

[0004] Hydrogel materials are three-dimensional networks formed by hydrophilic macromolecules or small molecules or polymers through covalent or non-covalent bonds. Hydrogel materials have good biocompatibility and can provide a moist environment for wound tissues to facilitate wound healing. However, while hydrogels provide a moist environment for tissues, they are also prone to invasion and proliferation of pathogenic microorganisms, increasing the incidence of infection during the use of hydrogels.

[0005] Among them, the antibacterial hydrogel formed by complexation of PDLA-CPC-PDLA triblock polymer and biodegradable PLLA-PEG-PLLA exists in the form of micelle solution at room temperature. When the temperature rises to 37 degrees, the micelle solution self-assembles to form nanobelts and nanofiber structures, and these nanostructures cross-link to form hydrogels. The bactericidal ability of the hydrogel to Gram-negative bacteria and Gram-positive bacteria has been greatly improved, and the degree of damage to red blood cells by the hydrogel is very low, which is convenient for wound tissue healing. However, due to the temperature-sensitive properties of the hydrogel, the hydrogel has a poor lamination effect, which slows down the healing process of the wound. Summary of the invention

[0006] The purpose of the present invention is to provide a pharmaceutical composition for treating diabetic foot ulcers, which is convenient for promoting the absorption of drugs by the wound and accelerating the healing process of the wound.

[0007] In order to achieve the above object, the technical solution of the present invention is as follows:

[0008] A pharmaceutical composition for treating diabetic foot ulcers, comprising Loropetalum damifolia extract, Angelica sinensis extract, Licorice root extract, Angelica dahurica extract and Lithospermum officinale extract.

[0009] Furthermore, according to weight ratio, the pharmaceutical composition includes 6-10 parts of Loropetalum dahliae extract, 6-10 parts of Angelica sinensis extract, 3-4 parts of Licorice extract, 1-1.4 parts of Angelica dahurica extract and 1.1-1.3 parts of Lithospermum officinale extract.

[0010] Furthermore, the weight ratio of the pharmaceutical composition is 10 parts of Loropetalum dahliae extract, 6 parts of Angelica sinensis extract, 3 parts of Licorice extract, 1 part of Angelica dahurica extract, and 1.2 parts of Lithospermum officinale extract.

[0011] Furthermore, the weight ratio of the pharmaceutical composition is 8 parts of Loropetalum dahliae extract, 7 parts of Angelica sinensis extract, 3 parts of Licorice extract, 1.2 parts of Angelica dahurica extract, and 1.1 parts of Lithospermum officinale extract.

[0012] Furthermore, the weight ratio of the pharmaceutical composition is 7 parts of Loropetalum dahliae extract, 10 parts of Angelica sinensis extract, 4 parts of Licorice extract, 1.4 parts of Angelica dahurica extract, and 1.3 parts of Lithospermum officinale extract.

[0013] Furthermore, the weight ratio of the pharmaceutical composition is 6 parts of Loropetalum dahliae extract, 7 parts of Angelica sinensis extract, 4 parts of Licorice extract, 1.3 parts of Angelica dahurica extract, and 1.3 parts of Lithospermum officinale extract.

[0014] Furthermore, the pharmaceutical composition is in the form of a gel.

[0015] Furthermore, the hydrogel carrier of the gel is an antibacterial hydrogel formed by complexation of PDLA-CPC-PDLA and PLLA-PEG-PLLA.

[0016] Furthermore, the antibacterial hydrogel is bonded to a self-heating dressing.

[0017] The following beneficial effects are achieved by adopting the above scheme:

[0018] Through the synergistic effect of different medicinal materials such as Loropetalum truncatum, Angelica sinensis, Licorice, Angelica dahurica and Lithospermum officinale, the wound can absorb the medicine for healing, thus accelerating the healing process of the wound.

[0019] In the early stage of wound healing, due to the temperature difference between the patient's foot temperature and the hydrogel, the drugs in the hydrogel tend to gradually accumulate on the wound surface to form a drug layer. Then, through continuous heating of the dressing, a hot compress effect is formed, which promotes blood circulation near the wound and facilitates the wound to absorb the drug.

[0020] At the same time, the hydrogel forms an outer protective layer and the drug forms an inner protective layer to block or kill bacteria and improve the bactericidal effect.

[0021] When the micelle solution changes from liquid to micro-solid, the volume of the hydrogel increases after absorbing water, pressing the wound surface to promote blood circulation, improve the wound's absorption of drugs, and accelerate the wound healing process. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a schematic diagram of wound healing of the pharmaceutical composition for treating diabetic foot ulcers according to the present invention.

[0023] Figure 2 A schematic diagram of a wound of a pharmaceutical composition for treating a diabetic foot ulcer according to the present invention.

[0024] Figure 3 This is a schematic diagram of the change in microgel state of the antibacterial hydrogel of the pharmaceutical composition for treating diabetic foot ulcers according to an embodiment of the present invention. DETAILED DESCRIPTION

[0025] The following is further described in detail through specific implementation methods:

[0026] Example 1

[0027] The embodiment is basically as shown in the attached Figures 1 to 3 Shown is a pharmaceutical composition for treating diabetic foot ulcers, comprising Loropetalum damifolia extract, Angelica sinensis extract, Licorice root extract, Angelica dahurica extract and Lithospermum officinale extract.

[0028] The weight ratio of the pharmaceutical composition is: 10 parts of Loropetalum damiana extract, 6 parts of Angelica sinensis extract, 3 parts of Licorice extract, 1 part of Angelica dahurica extract, and 1.2 parts of Lithospermum officinale extract.

[0029] The weight ratio of the pharmaceutical composition is 8 parts of Loropetalum dahliae extract, 7 parts of Angelica sinensis extract, 3 parts of Licorice extract, 1.2 parts of Angelica dahurica extract, and 1.1 parts of Lithospermum officinale extract.

[0030] The weight ratio of the pharmaceutical composition is 7 parts of Loropetalum dahliae extract, 10 parts of Angelica sinensis extract, 4 parts of Licorice root extract, 1.4 parts of Angelica dahurica extract, and 1.3 parts of Lithospermum officinale extract.

[0031] The weight ratio of the pharmaceutical composition is 6 parts of Loropetalum dahliae extract, 7 parts of Angelica sinensis extract, 4 parts of Licorice extract, 1.3 parts of Angelica dahurica extract, and 1.3 parts of Lithospermum officinale extract.

[0032] The application dosage form of the pharmaceutical composition is a gel; the hydrogel carrier of the gel is an antibacterial hydrogel formed by complexation of PDLA-CPC-PDLA and PLLA-PEG-PLLA; the antibacterial hydrogel is bonded to a self-heating dressing, and the dressing includes but is not limited to heating tools such as a hot pack.

[0033] The specific implementation process is as follows:

[0034] According to the records of Chinese medicinal materials, angelica has the effects of nourishing blood, activating blood circulation, regulating menstruation and relieving pain, and detoxifying; licorice has the effects of relieving acute pain and alleviating the medicinal properties; angelica dahurica has the effects of reducing swelling and discharging pus; lithospermum officinale has the effects of clearing heat and cooling blood, activating blood circulation and detoxifying, and removing rashes and spots. Through the synergistic effect of different medicinal materials, studies have shown that Loropetalum dahliae has a stronger healing effect. The extracts of each medicinal material are dissolved in water and then dissolved in the hydrogel, so that the extracts of each medicinal material are distributed in the hydrogel as a solution, which facilitates wound healing and accelerates the wound healing process.

[0035] The same method was used to test the drug compositions with different weight ratios to observe the bacterial survival on the wound surface, wound healing time, and wound scar depth.

[0036] In the early stage of wound healing, due to the poor blood circulation in diabetic patients, the body temperature of the patient's feet is easily lower than that of normal people, making it easy for the hydrogel attached to the surface to exist in the state of micro-particle solution, making it easy for the drug in the hydrogel to contact the wound and gradually accumulate on the wound surface to form a drug layer. Through continuous heating by the self-heating patch (such as a hot pack), a hot compress effect is formed, which promotes blood circulation near the wound and facilitates the wound to absorb the drug.

[0037] Because one side of the hydrogel is in a continuous heating state, the micelle solution formed on the wound surface continuously solidifies into a hydrogel state to form a protective layer. When different types of bacteria come into contact with the hydrogel surface, the hydrogel will destroy the morphology of the bacterial cell membrane / cell wall and kill the bacteria near the wound. At the same time, in the process of the drug contacting the wound, the formed drug layer becomes an inner protective layer to block the bacteria and improve the bactericidal effect.

[0038] When the micelle solution changes from liquid to micro-solid, the volume of the hydrogel increases after absorbing water, which promotes the fluidity of the drug in the hydrogel and facilitates the contact between the drug and the wound surface, thereby pressing the wound surface to promote blood circulation, improve the wound's absorption of the drug, and accelerate the wound healing process. Specific examples include Figure 3 As shown, b is a schematic diagram of the micro-particle solution in liquid state, c is a schematic diagram of the condensation of the micro-particle solution from liquid state to micro-solid state, d is a schematic diagram of the molecular state of the micro-particle solution in liquid state, and e is a schematic diagram of the molecular state of the micro-particle solution from liquid state to micro-solid state.

[0039] The above is only an embodiment of the present invention, and the common knowledge such as the known specific structure and / or characteristics in the scheme is not described in detail here. It should be pointed out that for those skilled in the art, several deformations and improvements can be made without departing from the structure of the present invention, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. A pharmaceutical composition for treating diabetic foot ulcers, characterized in that: The pharmaceutical composition comprises Loropetalum dahliae extract, Angelica sinensis extract, Licorice root extract, Angelica dahurica extract and Lithospermum officinale extract.

2. The pharmaceutical composition for treating diabetic foot ulcer according to claim 1, characterized in that: According to weight ratio, the pharmaceutical composition comprises 6-10 parts of Loropetalum damiana extract, 6-10 parts of Angelica sinensis extract, 3-4 parts of Licorice extract, 1-1.4 parts of Angelica dahurica extract and 1.1-1.3 parts of Lithospermum officinale extract.

3. The pharmaceutical composition for treating diabetic foot ulcer according to claim 2, characterized in that: The weight ratio of the pharmaceutical composition is: 10 parts of Loropetalum damiana extract, 6 parts of Angelica sinensis extract, 3 parts of Licorice extract, 1 part of Angelica dahurica extract, and 1.2 parts of Lithospermum officinale extract.

4. The pharmaceutical composition for treating diabetic foot ulcer according to claim 2, characterized in that: The weight ratio of the pharmaceutical composition is 8 parts of Loropetalum dahliae extract, 7 parts of Angelica sinensis extract, 3 parts of Licorice extract, 1.2 parts of Angelica dahurica extract, and 1.1 parts of Lithospermum officinale extract.

5. The pharmaceutical composition for treating diabetic foot ulcer according to claim 2, characterized in that: The weight ratio of the pharmaceutical composition is 7 parts of Loropetalum dahliae extract, 10 parts of Angelica sinensis extract, 4 parts of Licorice root extract, 1.4 parts of Angelica dahurica extract, and 1.3 parts of Lithospermum officinale extract.

6. The pharmaceutical composition for treating diabetic foot ulcer according to claim 2, characterized in that: The weight ratio of the pharmaceutical composition is 6 parts of Loropetalum dahliae extract, 7 parts of Angelica sinensis extract, 4 parts of Licorice extract, 1.3 parts of Angelica dahurica extract, and 1.3 parts of Lithospermum officinale extract.

7. The method for using the pharmaceutical composition according to any one of claims 3 to 6, characterized in that: The application dosage form of the pharmaceutical composition is a gel.

8. The method for using the pharmaceutical composition according to claim 7, characterized in that: The hydrogel carrier of the gelling agent is an antibacterial hydrogel formed by complexing PDLA-CPC-PDLA and PLLA-PEG-PLLA.

9. The method for using the pharmaceutical composition according to claim 8, characterized in that: The antimicrobial hydrogel is bonded to a self-heating dressing.

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