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88 results about "Redox status" patented technology

The average glutathione redox status for adults through the age of 45 is about -148 mV, with the majority having values between -140 and -150 and most having values between -130 and -160. After the age of 45, the average magnitude of the redox status decreases linearly with age by about 7 mV per decade.

Oxidation reduction sensitive green fluorescent protein variants

The disclosure provides proteins that can be used to determine the redox status of an environment (such as the environment within a cell or subcellular compartment). These proteins are green fluorescent protein (GFP) variants (also referred to as redox sensitive GFP (rosGFP) mutants), which have been engineered to have two cysteine amino acids near the chromophore and within disulfide bonding distance of each other. Also provided are nucleic acid molecules that encode rosGFPs, vectors containing such encoding molecules, and cells transformed therewith. The disclosure further provides methods of using the rosGFPs (and encoding molecules) to analyze the redox status of an environment, such as a cell, or a subcellular compartment within a cell. In certain embodiments, both redox status and pH are analyzed concurrently.
Owner:OREGON HEALTH & SCI UNIV

Widely wavelength tuneable polychrome colloidal photonic crystal device

The present invention discloses a widely wavelength tunable polychrome colloidal photonic crystal device whose optical Bragg diffraction stop bands and higher energy bands wavelength, width and intensity can be tuned in a continuous and fine, rapid and reversible, reproducible and predictable fashion and over a broad spectral range by a controlled expansion or contraction of the colloidal photonic lattice dimension, effected by a predetermined change in the electronic configuration of the composite material. In its preferred embodiment, the material is a composite in the form of a film or a patterned film or shape of any dimension or array of shapes of any dimension comprised of an organized array of microspheres in a matrix of a cross-linked metallopolymer network with a continuously variable redox state of charge and fluid content. The chemo-mechanical and electro-mechanical optical response of the colloidal photonic crystal-metallopolymer gel is exceptionally fast and reversible, attaining its fully swollen state from the dry shrunken state and vice versa on a sub-second time-scale. These composite materials can be inverted by removal of the constituent microspheres from the aforementioned colloidal photonic crystal metallopolymer-gel network to create a macroporous metallopolymer-gel network inverse colloidal photonic crystal film or patterned film or shape of any dimension optical Bragg diffraction stop bands and higher energy bands wavelength, width and intensity can be redox tuned in a continuous and fine, rapid and reversible, reproducible and predictable fashion and over a broad spectral range by a controlled expansion or contraction of the colloidal photonic lattice dimensions.
Owner:THE GOVERNINIG COUNCIL OF THE UNIV OF TORANTO

Phasor Method to Fluorescence Lifetime Microscopy to Discriminate Metabolic State of Cells in Living Tissue

“A label-free imaging method to monitor stem cell metabolism discriminates different states of stem cell as they differentiate in a living tissues. We use intrinsic fluorescence biomarkers and the phasor approach to Fluorescence Lifetime Imaging Microscopy (FLIM). We identify and map intrinsic fluorophores such as collagen, retinol, retinoic acid, flavins, nicotinamide adenine dinucleotide (NADH) and porphyrin. We measure the phasor values of germ cells in C. Elegans germ line. Their metabolic fingerprint cluster according to their differentiation state, reflecting changes in FAD concentration and NADH binding during the differentiation pathway. The phasor approach to lifetime imaging provides a label-free, fit-free and sensitive method to identify different metabolic state of cells during differentiation, to sense small changes in the redox state of cells and may identify symmetric and asymmetric divisions and predict cell fate.”
Owner:RGT UNIV OF CALIFORNIA

Quinone derivatives for use in the modulation of redox status of individuals

InactiveUS20150216820A1Restoration of balance controlRestoration of metabolic controlBiocideSenses disorderDiseaseQuinone
Methods of modulating, adjusting, and maintenance of the glutathione redox status of an individual, or cell, tissues, bodily fluids, or body compartments of the individual, are disclosed, as are compositions suitable for such modulating, adjusting, and maintenance. The modulation or adjustment is achieved by altering the amounts of reduced glutathione versus oxidized glutathione in the individual, or cells, tissues, bodily fluids, or body compartments of the individual. Modulation, adjustment, and maintenance of the redox status of an individual enables treatment, prevention or suppression of diseases or symptoms associated with diseases. These methods are achieved by using quinone derivatives.
Owner:BIOELECTRON TECH CORP

Biooxidation process for recovery of metal values from sulfur-containing ore materials

A process for the recovery of one or more metal values from a metal ore material comprising those of one or more values and a matrix material having a sulfur content wherein the sulfur is present in an oxidation-reduction state of zero or less comprisinga. forming particulates from particles of said ore and an inoculate comprising bacteria capable of at least partially oxidizing the sulfur content;b. forming a heap of said particulates;c. biooxidizing the sulfur content andd. recovering those one or more metal values.
Owner:NEWMONT USA LTD

Widely wavelength tuneable polychrome colloidal photonic crystal device

The present invention discloses a widely wavelength tunable polychrome colloidal photonic crystal device whose optical Bragg diffraction stop bands and higher energy bands wavelength, width and intensity can be tuned in a continuous and fine, rapid and reversible, reproducible and predictable fashion and over a broad spectral range by a controlled expansion or contraction of the colloidal photonic lattice dimension, effected by a predetermined change in the electronic configuration of the composite material. In its preferred embodiment, the material is a composite in the form of a film or a patterned film or shape of any dimension or array of shapes of any dimension comprised of an organized array of microspheres in a matrix of a cross-linked metallopolymer network with a continuously variable redox state of charge and fluid content. The chemo-mechanical and electro-mechanical optical response of the colloidal photonic crystal-metallopolymer gel is exceptionally fast and reversible, attaining its fully swollen state from the dry shrunken state and vice versa on a sub-second time-scale. These composite materials can be inverted by removal of the constituent microspheres from the aforementioned colloidal photonic crystal metallopolymer-gel network to create a macroporous metallopolymer-gel network inverse colloidal photonic crystal film or patterned film or shape of any dimension optical Bragg diffraction stop bands and higher energy bands wavelength, width and intensity can be redox tuned in a continuous and fine, rapid and reversible, reproducible and predictable fashion and over a broad spectral range by a controlled expansion or contraction of the colloidal photonic lattice dimensions.
Owner:THE GOVERNING COUNCIL OF THE UNIV OF TORONTO

Transcriptional Profiling and Biomarker-Based Methods for Identifying and Evaluating Agents for Antioxidant Efficacy in Cosmetic Skin Care Formulations

Gene panels, microarrays and biomarker panels relating to genes and gene products associated with age-related oxidative damage to skin, and transcriptional profiling-based methods for identification and evaluation of cosmetic agents for prevention, reversal, or reduction of oxidative damage to skin. Cosmetic agents and compositions comprising the cosmetic agents, capable of inducing nrf2-mediated activation of the antioxidant response element to increase expression of Phase 2 enzymes, methods for restoring optimal redox status to skin employing the agents, and methods for identifying and evaluating cosmetic agents acting via the nrf2-mediated mechanism.
Owner:THE PROCTER & GAMBLE COMPANY

Control of cellular redox levels

Disclosed herein are compositions and methods for regulating redox status and / or reducing oxidative stress in a subject, the methods and compositions comprising TLR agonists comprising bacterial lysates and / or lysate fractions. Also disclosed are compositions and methods comprising bacterial lysates and / or lysate fractions formulated or administered in combination with one or more other therapeutic or pharmaceutical agents.
Owner:伊丽莎白麦克纳

Particulate of sulfur-containing ore materials and heap made therefrom

Disclosed is a particulate of an ore material having a metal value metal value and a matrix material having a sulfur content wherein the sulfur is present in an oxidation-reduction state of zero or less, the particulate comprising (a) a core particle of the ore material, with the core particle having a size of less than about two inches; and (b) a layer of particles of the ore material and an inoculate of sulfur biooxidizing bacteria in admixture with the particles; wherein the particulate has sufficient strength to retain at least about 95% of a void volume for a column height of about 6 feet for at least 200 days when continuously bathed in a solution comprised of the inoculate or a nutrient therefor. Also disclosed is a heap comprising a plurality of the particulate.
Owner:NEWMONT USA LTD

Micro gap flow through electrochemical devices with self adjusting reactive surfaces

Contemplated electrochemical devices and methods include an electrolyte flow path in which substantially all of the electrolyte has laminar flow. A segmented electrode contacts the electrolyte, and each of the segments in the segmented electrode is preferably coupled to a control device to provide control over the flow of current to and / or from the electrolyte. Thus, it should be appreciated that the redox state of the electrolyte can be changed in a single-pass through the flow path, which effectively eliminates problems associated with mass transport phenomena and reduced current efficiency.
Owner:CLARKE RICHARD

Modulation of cell fates and activities by diketo phthalazines

Phthalazine diones that function as intracellular redox modulators and buffers are used to treat stressed cells in various disease states in which the intracellular redox status is impaired. By optimal buffering of aberrant redox states, phthalazine diones enhance the cellular processes essential for survival and augment the conventional or other external therapies necessary for treatment. The phthalazine diones of the invention thus regulate cell growth, differentiation, or death to serve as essential adjunctive therapy for the stressed host in various disease states.
Owner:BACH PHARMA

Electrochemical device

An electrochemical device is provided, comprising a source contact connected to a first antenna pad, a drain contact connected to a second antenna pad, at least one gate electrode, an electrochemically active element arranged between, and in direct electrical contact with, the source and drain contacts, which electrochemically active element comprises a transistor channel and is of a material comprising an organic material having the ability of electrochemically altering its conductivity through change of redox state thereof, and a solidified electrolyte in direct electrical contact with the electrochemically active element and the at least one gate electrode and interposed between them in such a way that electron flow between the electrochemically active element and the gate electrode(s) is prevented. In the device, flow of electrons between source contact and drain contact is controllable by means of a voltage applied to the gate electrode(s).
Owner:KUGLER THOMAS +5

Electroactive fluorescent polymer, preparation method and use for detecting oxidizing or reducing substance

The invention belongs to the field of a functional high molecular material, and particularly relates to a series of side chain type electroactive fluorescent polymers, a preparation method and use for detecting an oxidizing or reducing substance. Fluorescence detection of the oxidizing or reducing substance is realized by utilizing the characteristic that the fluorescence intensity of the electroactive fluorescent polymer reversibly changes along with an oxidation reduction state of an aniline chain segment. The preparation method comprises the following steps of: synthesizing the fluorescentpolymer containing the aniline chain segment and a fluorescent group on a side chain through a ternary polymerization method; after preparing polymer into solution, keeping the aniline chain segment in the polymer in a reducing state or intermediate oxidizing state by using a chemical oxidation reduction method or electrochemical method; and then testing a fluorescence response situation of the aniline chain segment to the oxidizing or reducing substance by using a fluorescent spectrometer. The detection method has the advantages of wide variety of detection objects, high stability, low detection lower limit, reusability and the like, and has extremely broad application prospect in the fields of biology, chemistry, foods, environment and the like.
Owner:JILIN UNIV

Oxidation reduction sensitive green fluorescent protein variants

The disclosure provides proteins that can be used to determine the redox status of an environment (such as the environment within a cell or subcellular compartment). These proteins are green fluorescent protein (GFP) variants (also referred to as redox sensitive GFP (rosGFP) mutants), which have been engineering to have two cysteine amino acids near the chromophore and within disulfide bonding distance of each other. Also provided are nucleic acid molecules that encode rosGFPs, vectors containing such encoding molecules, and cells transformed therewith. The disclosure further provides methods of using the rosGFPs (and encoding molecules) to analyze the redox status of an environment, such as a cell, or a subcellular compartment within a cell. In certain embodiments, both redox status and pH are analyzed concurrently.
Owner:STATE OF OREGON ACTING BY & THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE OREGON HEALTH SCI UNIV

Multi-electrode chemiresistor

The invention relates to “solid state” chemiresistor sensors with electric control of the affinity of a chemosensitive material. The configurations of the present invention enable the fast regeneration of the sensor after analyte binding, which therefore increases selectivity. In one embodiment the chemiresistor sensor is implemented as a multi-electrode chemiresistor, comprising 4 electrodes for the separate measurement of the resistance of the chemosensitive material and the contact resistance, and 2 further electrodes to control the redox state of the chemosensitive sensor material, thereby facilitating fast and effective regeneration of the sensor.
Owner:BRANDENBURGISCHE TECHN UNIV COTTBUS SENFTENBERG

Treatment of metastatic tumors and other conditions

The present invention generally relates to pharmacology and, in particular, to the treatment of tumors and other conditions. In some aspects, the invention is directed to the treatment of subjects having tumors or cancers that are metastatic. Surprisingly, it has been found that certain compositions comprising oxidized glutathione-based compounds are able to effectively treat such cancers by inhibiting cell migration and / or invasion processes, and thus, inhibiting tumor cell metastases. Without being bound by any theory, it is believed that such compositions are effective since the compositions are able to suppress the activation of critical signaling pathways within cells that are used for cell migration, such as the ErbB2 and / or phosphoinositide-3 kinase (PI3K) pathways, including the downstream RhoA and AKT pathways. Such pathways are regulated by ERp5, which is a protein disulfide isomerase regulated using certain redox pathways, and those redox pathways are unusually sensitive to treatment using oxidized glutathione-based compounds. Thus, the composition of the instant invention, in some embodiments, are surprisingly effective at preventing tumor metastases. While other references have disclosed the treatment of cancers using oxidized glutathione-based compounds, no reference has suggested that signaling pathways used for cell migration, invasion and metastasis, such as the ErbB2, PI3K, RhoA, and AKT pathways, are highly susceptible to treatment by altering the redox state of the cell, e.g., by oxidized glutathione-based compounds. Accordingly, the use of such compositions to treat tumor metastases is surprising and could not be predicted given the teachings of the prior art.
Owner:NOVELOS THERAPEUTICS +1

Device and method for melting a substance with the occurrence of a low level of contamination

The invention relates to an apparatus and a method for low-contamination melting of high-purity, aggressive and / or high-melting glass or glass-ceramic. According to the invention, for this purpose a melt is heated in a crucible or melting skull crucible by means of high-frequency radiation and is mixed or homogenized in the melting crucible. It is preferable for a gas nozzle, from which gas bubbles, e.g. oxygen bubbles (known as O2 bubbling), escape into the melt, to be provided at the base of the crucible. This alone makes it possible to achieve surprising multiple benefits in the melting skull crucible. Firstly, unmelted batch which drops into the melt in solid form, for example from above, is melted down more quickly as a result of more intensive mixing with the liquid fraction of the melt, secondly the temperature distribution in the melt is made more even, thirdly a uniform distribution or mixing of different glass constituents is achieved, and fourthly the redox state of the glass can be adjusted.
Owner:SCHOTT AG

Macrocycles, cobalt and iron complexes of same, and methods of making and using same

Provided are macrocyclic compounds and iron or cobalt coordinated macrocyclic compounds. The compounds can be used as MRI contrast agents. Certain compounds are redox active and can be used to assess the biological redox status of a sample.
Owner:HEALTH RES INC +1

Micro Gap Flow Through Electrochemical Devices With Self Adjusting Reactive Surfaces

Contemplated electrochemical devices and methods include an electrolyte flow path in which substantially all of the electrolyte has laminar flow. A segmented electrode contacts the electrolyte, and each of the segments in the segmented electrode is preferably coupled to a control device to provide control over the flow of current to and / or from the electrolyte. Thus, it should be appreciated that the redox state of the electrolyte can be changed in a single-pass through the flow path, which effectively eliminates problems associated with mass transport phenomena and reduced current efficiency.
Owner:CLARKE RICHARD

Ascorbic acid conjugates

Oxidative stress, resulting from the generation of reactive oxygen species, contributes to the development of a multitude of age-related diseases. Current methods of assessing oxidative stress levels range from the detection of lipid peroxidation products, such as F2-isoprostanes and malondialdehyde, to monitoring the redox status of glutathione. While useful, traditional biomarkers of oxidative stress are not without their drawbacks, including low in vitro concentrations and possible artifact formation. Disclosed herein are new marker compounds, including ascorbylated 4-hydroxy-2-nonenal, that are useful as biomarkers of oxidative stress.
Owner:THE STATE OF OREGON ACTING BY & THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIV

Stable electrochromic module

ActiveUS20150378234A1Few technologically simple, environmentally friendly and inexpensive stepsDecline in electrochromic propertyNon-linear opticsSwitching cycleElectrochromism
Electrochromic module including first and second substrates is provided in which the first and / or second substrate are / is electrically conductive or are / is equipped with an electrically conductive coating. A first electrochromic polymer coating is arranged on the first substrate or the conductive coating, an ion-storage or charge-compensating layer is arranged on the second substrate or the conductive coating, and a polymer gel electrolyte is disposed between the electrochromic coating and the ion-storage or charge-compensating layer. The electrochromic polymer, a polymer of tetraarylbenzidine and (hetero)aromatic diol, is colourless in one redox state and colored in at least two redox states. The ion-storage or charge-compensating layer is formed from material selected from the group comprising cerium oxide, titanium oxide, tungsten oxide, nickel oxide, molybdenum oxide, vanadium oxide and mixtures thereof or redox-active polymer. The inventive modules achieve a large number of switching cycles, a high electrochromic contrast and a high electrochromic efficiency.
Owner:THURINGISCHES INSTITUT FUR TEXTIL & KUNST FORSCHUNG

Electrochemical device

An embodiment of the present invention relates to electrochemical devices including an electrochemically active layer having the ability of electrochemically altering its redox state. By providing a portion of an electrode of corrosion resistant material between an electrolyte and an electrochemically active layer, undesired discoloration due to the electrochemical reaction of an electrochemical device is reduced.
Owner:ACREO SWEDISH ICT

Fiber-based organic electrochemical transistor

An organic electrochemical transistor (OECT) that may be used as a biosensor is built up by layers applied to a monofilament. A first conducting layer applied to the monofilament includes generally cylindrical source and drain contacts with a gap therebetween. An electro-active layer of an organic material altering its electrical conductivity through a change in redox state is in electrical contact with the source and drain contacts, and has a transistor channel interface for contacting an electrolyte. A gate electrode is spaced apart from the first monofilament, and may comprise a cylindrical layer built up on another length of monofilament.
Owner:THE HONG KONG POLYTECHNIC UNIV

Refolding proteins using a chemically controlled redox state

A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g / L or higher is disclosed. The method comprises identifying the thiol pair ratio and the redox buffer strength to achieve conditions under which efficient folding at concentrations of 2.0 g / L or higher is achieved and can be employed over a range of volumes, including commercial scale.
Owner:AMGEN INC

Metal-Organic Frameworks for Adsorption of Liquid Phase Compounds

The present invention provides for the use of a metal-organic framework (MOF) in removing particular chemical species or compounds, in particular oxy-anions, from a liquid or liquid stream. In some embodiments, the MOF is a Zr-based MOF, such as NU-1000, and the oxy-anions that are removed include, include, for example, oxy-anions of selenium, including selenite (SeO32−) and selenate (SeO42−); oxy-anions of antimony, including oxy-anions in either the Sb[III] (antimonite) or the Sb[V] (antimonate) redox state; and oxy-anions of lead, including oxy-anions in either the Pb[II] or the Pb[IV] redox state, such as Pb(OH)62−, Pb(OH)64−, PbO32−, and PbO22−. The Zr-based MOF, including NU-1000 can be used to remove these oxy-anions from various liquid streams in industrial processes such as a nuclear and fossil fuel power plants, including the latter's flue gas desulfurization system.
Owner:NORTHWESTERN UNIV
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