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Preparation for vascular graft with anti-thrombosis and anti-platelet adhesiveness potentials

An anti-platelet and vascular transplantation technology, applied in the field of vascular graft preparation, can solve problems such as unsatisfactory results, source and strength limitations

Inactive Publication Date: 2019-05-28
南杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Autovascular is widely used clinically, but due to the limitation of source and intensity, satisfactory results cannot be achieved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Take 0.1 g of commercially available collagen and soak it in 100 ml of 0.2 mol / L acetic acid solution. Stir well to fully dissolve, then place in the glass tube of a tumble mixer and roll the coating. Pour off excess collagen solution after forming a uniform collagen film. Pour 0.1 g of commercially available polyethylene glycol into 100 ml of sterilized physiological saline and stir evenly, take an appropriate amount of ethylene glycol liquid and drop it on the collagen film, and roll the coating with a drum agitator. Press 1.25×10 5 Add the recipient's own bone marrow-differentiated smooth muscle cells at a concentration of 1 / ml, plant continuously for 2 days, and then simultaneously press 1.25×10 5 Individual / ml concentration planted recipient's own bone marrow differentiated fibroblasts. They were planted continuously for 3 days. Next, the recipient's own bone marrow vascular endothelial progenitor cells and vascular endothelial growth factor were planted at a c...

Embodiment 2

[0012] Take 0.2 g of commercially available collagen and soak it in 100 ml of 0.5 mol / L acetic acid solution. Stir well to fully dissolve, then place in the glass tube of a tumble mixer and roll the coating. Pour off excess collagen solution after forming a uniform collagen film. Pour 0.5 g of commercially available polyethylene glycol into 100 ml of sterilized physiological saline and stir evenly, take an appropriate amount of ethylene glycol liquid and drop it on the collagen film, and roll the coating with a drum agitator. Press 1.25×10 5 Add the recipient's own bone marrow-differentiated smooth muscle cells at a concentration of 1 / ml, plant continuously for 2 days, and then simultaneously press 1.25×10 5 Individual / ml concentration planted recipient's own bone marrow differentiated fibroblasts. They were planted continuously for 3 days. Next, the recipient's own bone marrow vascular endothelial progenitor cells and vascular endothelial growth factor were planted at a c...

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PUM

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Abstract

The invention relates to a preparation for a vascular graft with anti-thrombosis and anti-platelet adhesiveness potentials and belongs to the field of medical biological materials. The invention aimsto solve the problems of limited autologous blood vessels and complex operation, high risk of allogeneic blood vessels, poor compliance or calcification of high polymer materials implanted to body, and the like, in clinics at present. The vascular graft is prepared through the following steps: planting autologous histocytes of receptor in three layers according to the characteristics of differentstructures and different histocytes of natural blood vessels, and then simulating mechanical parameters endured by in vivo blood vessels and blood flow situation. A purpose of repairing autologous blood vessels can be achieved. The material prepared according to the method is formed by culturing collagen and autologous histocytes of receptor in a blood vessel bioreactor, is approximate to autologous blood vessels, has high biocompatibility, has a growth potential, is unlikely to be infected, has stronger mechanical properties, is capable of bearing the resilience of interwall pressure and blood to vascular walls, has an excellent effect of resisting against thrombosis and platelet adhesiveness and is beneficial to vascular repair of vascular transplantation.

Description

technical field [0001] The invention relates to the preparation of a blood vessel graft with anti-thrombosis and anti-platelet adhesion potential, belonging to the field of medical biomaterials. Background technique [0002] Arterial ischemic disease represented by atherosclerotic heart disease is one of the main causes of human death. The main treatment is arterial grafting. In addition, congenital heart disease is a common congenital malformation that requires surgical correction, and some complicated congenital heart disease operations also require the application of vascular grafts. In the past, most of the vascular grafts we used were polymer artificial materials, such as polyester, polytetrafluoroethylene, etc., and each had its own advantages and disadvantages. At present, the same kind of blood vessels is the most used at home and abroad, but the source of the same kind of blood vessels is limited. At the same time, the same kind of blood vessels have been cryopres...

Claims

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Application Information

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IPC IPC(8): A61F2/06
Inventor 南杰
Owner 南杰
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