The invention relates to the technical field of cosmetics and particularly relates to efficiently atomized spray having a function of skin care and a preparation method thereof. The spray has small droplet diameters and a narrow droplet diameter spectrum. The droplet movement speed is slow and the liquid use amount per unit area is uniform. The spray has a good skin care effect. The spray comprises purified water, glycerol, 1, 3-butanediol, 1, 3-propanediol, 1, 2-hexanediol, 1, 2-pentanediol, betaine, allantoin, polyglyceryl-10-isostearate, PPG-26-butanol polyether-26/PEG-40 hydrogenated castor oil/water, saccharide isomeride/water/citric acid/sodium citrate, PCA cocoyl arginine ethyl ester, caprylic/capric triglyceride, nicotinamide, purslane extract, water/hydrolyzed royal jelly protein/butanediol, water/glycerol/1, 2-hexanediol/1, 2-pentanediol/beta-glucan, menthol lactate/menthol, methyl diisopropyl propionamide, and octanoyl hydroxamic acid/1, 3-propanediol. The spray is used through a spray bottle, has good atomization effects, high efficiency of deposition on the skin and has good skin care effects.