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Gastrodine solid dispersible tablet preparation and preparation method thereof

A technology of solid dispersion and gastrodin, applied in the field of medicine, can solve the problems of low bioavailability, poor oral absorption, etc., achieve good reproducibility, improve poor taste, and realize the effect of mass production

Active Publication Date: 2012-06-27
YANGZHOU ZHONGBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a gastrodin solid dispersible tablet preparation to improve poor oral absorption and low bioavailability

Method used

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  • Gastrodine solid dispersible tablet preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A gastrodin solid dispersible tablet preparation comprises the following components by weight percentage:

[0026] Gastrodin 25%,

[0027] Hydroxypropyl Methyl Cellulose Phthalate 30%,

[0028] Macrogol 6000 25%,

[0029] Hydroxypropyl Methyl Cellulose 10%,

[0030] Magnesium Stearate 10%.

[0031] The production method is as follows:

[0032] (1) Weigh hydroxypropyl methylcellulose phthalate and polyethylene glycol 6000, and heat to melt under oil bath conditions;

[0033] (2) Gastrodin was added to the melt obtained in step (1) under slow stirring conditions of 200r / min, and then stirred for 30min under stirring conditions of 20000r / min after all adding;

[0034] (3) The melt obtained in step (2) is rapidly cooled and solidified in an ice-salt bath, then placed at -20°C for 1 hour, taken out, and dried in a desiccator for 24 hours;

[0035] (4) pulverize the dry matter obtained in step (3) and cross an 80 mesh sieve to obtain a gastrodin solid dispersion;

[00...

Embodiment 2

[0038] A gastrodin solid dispersible tablet preparation comprises the following components by weight percentage:

[0039] Gastrodin 25%,

[0040] Propyl Cellulose Acetate 27%,

[0041] Macrogol 2000 29%,

[0042] Sodium Carboxymethyl Cellulose 15%,

[0043] Magnesium Stearate 4%.

[0044] The production method is as follows:

[0045] (1) Weigh propyl acetate cellulose and polyethylene glycol 2000, and heat to melt under oil bath conditions;

[0046] (2) Gastrodin is added to the melt obtained in step (1) under 300r / min slow stirring condition, and after all adding, stir 30min under 10000r / min stirring condition;

[0047] (3) The melt obtained in step (2) is rapidly cooled and solidified in an ice-salt bath, then placed at -20°C for 1 hour, taken out, and dried in a desiccator for 24 hours;

[0048] (4) pulverize the dry matter obtained in step (3) and cross an 80 mesh sieve to obtain a gastrodin solid dispersion;

[0049] (5) The dispersion obtained in step (4) is mixed...

Embodiment 3

[0051] A gastrodin solid dispersible tablet preparation comprises the following components by weight percentage:

[0052] Gastrodin 25%,

[0053] Acrylic resin RL100 24%,

[0054] Polyvinylpyrrolidone 29%,

[0055] Microcrystalline Cellulose 15%,

[0056] Micronized silica gel 7%.

[0057] The production method is as follows:

[0058] (1) Weigh acrylic resin RL100 and polyvinylpyrrolidone, and heat to melt under oil bath conditions;

[0059] (2) Gastrodin was added to the melt obtained in step (1) under slow stirring conditions of 400r / min, and then stirred for 20min under stirring conditions of 30000r / min after all adding;

[0060] (3) The melt obtained in step (2) is rapidly cooled and solidified in an ice-salt bath, then placed at -20°C for 1 hour, taken out, and dried in a desiccator for 24 hours;

[0061] (4) pulverize the dry matter obtained in step (3) and cross an 80 mesh sieve to obtain a gastrodin solid dispersion;

[0062] (5) Mix the dispersion obtained in ste...

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Abstract

The invention discloses a gastrodine solid dispersible tablet preparation, which contains the components in percentage by weight as follows: 25% of gastrodine,20-30% of enteric solubility carrier material,25-30% of water soluble carrier material,7-17% of conglutinate agent,and 3-13% of flow aid. The invention also discloses a preparation method of the gastrodine solid dispersible tablet preparation. The gastrodine solid dispersible tablet disclosed by the invention improves the defects of poor taste poor compliance, and low bioavailability of gastrodine oral preparation. The preparation technology research of the modern solid dispersive technique of gastrodine solves the defects, the medicine bioavailability is improved, the target is strengthened, slow release function is provided, thus the therapeutic action of gastrodine is played fully, the method is simple to operate, has good reproducibility, is easy to realize mass production, also in vivo slow release of gastrodine is controlled by optimizing the proportioning of the enteric solubility carrier material and the water soluble carrier material, and the aim of exerting curative effect preferably is achieved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a gastrodin solid dispersible tablet preparation and a preparation method thereof. Background technique [0002] Gastrodia elata is one of the precious Chinese medicinal materials in my country, which is the dry tuber of orchidaceae. Widely produced in Yunnan, Guizhou, Sichuan, Shaanxi and other places. As early as 2,000 years ago, "Shen Nong's Materia Medica" recorded that Gastrodia elata has the functions of calming the liver and relieving wind, dredging collaterals and relieving pain. Modern pharmacological research proves that Gastrodia elata has sedative, anticonvulsant, analgesic, anti-inflammatory effects, anti-aging, improvement of learning and memory, different effects on high-level nerve center and cardiovascular, and has little toxicity. Tablets and capsules are currently on the market, which are clinically used for symptoms such as dizziness, neurasthen...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/7034A61K47/32A61K47/34A61K47/36A61K47/38A61P25/00A61P25/04A61P25/08A61P25/20A61P29/00A61P39/06A61K47/10
Inventor 葛海涛唐俊
Owner YANGZHOU ZHONGBAO PHARMA
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