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Preparation method of pseudo-ginseng dysmenorrhea dispersible tablets

A technology for dispersible tablets and dysmenorrhea, which is applied in the field of preparation of dispersible tablets for dysmenorrhea drugs, can solve the problems of slow disintegration, poor compliance, and low bioavailability, and achieve good stability, low cost, and high bioavailability of the preparation Effect

Inactive Publication Date: 2013-02-13
哈药集团中药二厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the technical problems of slow disintegration, low bioavailability and poor compliance of the existing Tianqi dysmenorrhea drug, thereby providing a preparation method of Tianqi dysmenorrhea dispersible tablets

Method used

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Experimental program
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Effect test

specific Embodiment approach 1

[0016] Specific embodiment one: the preparation method of a kind of Tianqitongjing dispersible tablet of the present embodiment is carried out according to the following steps:

[0017] 1. Weigh 50 to 100 parts of Tian Qi, 1000 to 2000 parts of ethanol solution with a volume concentration of 70% to 75%, 50 to 100 parts of Wulingzhi, and 30 to 60 parts of Puhuang according to the ratio of parts by mass , 50-100 parts of Yanhusuo, 50-100 parts of Chuanxiong, 50-100 parts of fennel, 30-60 parts of woody fragrance, 3000-6000 parts of deionized water, 2-6 parts of borneol, 180-300 parts 100-200 parts of microcrystalline cellulose, 100-200 parts of mannitol, 20-40 parts of crospovidone and 4-6 parts of magnesium stearate;

[0018] 2. Take 900-1500 parts of Hetianqi from the ethanol solution weighed in step 1, mix them, soak them for 0.5-1 hour, decoct them for 2-4 times, filter, combine the decoction liquid, and then put them at a temperature of 60-80℃ The decoction is concentrated...

specific Embodiment approach 2

[0027]Specific embodiment two: the difference between this embodiment and specific embodiment one is: in step 1, the volume concentration of 60 parts of Tianqi, 1080 parts by weight is 75% ethanol solution, 60 parts of Wuling butter, 40 parts of Puhuang, 60 parts of Yanhusuo, 60 parts of Chuanxiong, 60 parts of fennel, 40 parts of woody fragrance, 5440 parts of deionized water, 4 parts of borneol, 200 parts of microcrystalline cellulose, 167 parts of mannitol, 16 parts of crospovidone and 5 parts of magnesium stearate. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0028] Specific embodiment 3: The difference between this embodiment and specific embodiment 1 or 2 is that in step 2, at a temperature of 70°C, the decoction is concentrated to a relative density of 110 g / cm 3 . Others are the same as in the first or second embodiment.

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Abstract

The invention provides a preparation method of pseudo-ginseng dysmenorrhea dispersible tablets, relates to a preparation method of dysmenorrhea medicinal dispersible tablets, and aims at solving technical problems of slow disintegrating release, low bioavailability and poor compliance of a conventional pseudo-ginseng medicament. The preparation method comprises the following steps of: 1, weighing raw materials in parts by mass; 2, preparing pseudo-ginseng dry extract powder; 3, preparing raw material medicinal powder; 4, preparing mixed powder; and 5, preparing pseudo-ginseng dymenorrhea dispersible tablets. The pseudo-ginseng dysmenorrhea dispersible tablets prepared by the method are good in stability and high in oral bioavailability, have small hygroscopicity in the preparing process, do not require coating, are quick in disintegration and absorption, and can quickly relieve various symptoms caused by dysmenorrhea. The preparation method is applicable to the field of dysmenorrhea medicament preparation.

Description

technical field [0001] The invention relates to a preparation method of a dispersible tablet for dysmenorrhea medicine. Background technique [0002] Because Tianqi Tongjing Capsules and Tianqi Tongjing Powder have the effects of regulating qi and blood, relieving pain and regulating menstruation, they are used for menstrual abdominal pain and menstrual disorders caused by cold, and are considered to be good medicines for treating dysmenorrhea in clinical practice. Tongjingsan and Tianqi Tongjing Capsules have backward preparation technology, and all medicines are simply crushed. Powders are directly dispensed. Capsules are filled directly after the lubricant is added. Although the powder disintegrates quickly in the gastrointestinal tract, the packaging is not accurate and it is inconvenient to take. The disintegration and absorption of the capsule dosage form is slow. Both Tianqi Tongjing Powder and Tianqi Tongjing Capsules are made of raw medicinal materials containin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61K9/20A61K47/38A61K47/12A61P15/00A61K35/24
Inventor 刘景国柳松林范勤利李文军郑玥肇静静裴福成李殿明王英新隋艳君
Owner 哈药集团中药二厂
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