Iron sucrose injection and preparation method thereof

Abstract

The invention relates to a preparation method of iron sucrose injection. The method comprises the steps of (1) alkalization; (2) complexation; (3) alcohol precipitation; (4) powder collection, comprising the procedures of performing solid-liquid separation on alcohol precipitation solution by a centrifugal machine, spray drying the solid phase and collecting powder to obtain a bulk drug of the iron sucrose; (5) injection preparation, comprises the steps of adding the bulk drug of the iron sucrose in injection water to prepare a solution containing 100-300 mg of iron element in every milliliter, adding a 20-40% NaOH solution for alkalization, controlling a pH value at 11, heating and controlling a temperature at 40-80 DEG C, then adding 1-0.3% of activated carbon, stirring for 15-60 minutes, filtering with a 0.22 [mu]m micro-filtration membrane, heating with steam and controlling the temperature at 110-120 DEG C, and keeping the temperature for 30 minutes to obtain a finished product of the iron sucrose injection. The preparation method of the iron sucrose injection is simple in process steps, has easily controllable reaction process, good product quality, high yield and low production cost, and is a preparation method of the iron sucrose injection, with relatively high innovativeness.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, in particular to an iron sucrose injection and a preparation method thereof. Background technique [0002] In the feeding process of piglets, the intake of iron is very important. Iron is a trace element necessary for the body. It is an essential component for the body to synthesize hemoglobin. It is also myoglobin, cytochrome, and cytochrome. Components such as enzymes and peroxidases. Primary iron deficiency can cause anemia in newborn piglets. According to statistics, about 30% of piglets die due to iron deficiency. Piglets suffering from anemia mainly occur at the age of 2 to 4 weeks, and the faster the piglets grow, the more iron they store. The faster the amount is consumed, the higher the incidence of anemia. If the iron element is not supplemented in time, it will bring the following unfavorable factors to piglets: (1) cannot form hemoglobin, myoglobin, cytochrome enzymes and various ...

AI Technical Summary

Problems solved by technology

If the iron element is not supplemented in time, it will bring the following unfavorable factors to piglets: (1) cannot form hemoglobin, myoglobin, cytochrome enzymes and various peroxidases, thereby affecting the delivery of nutrients in the body; (2) Low hemoglobin content, low oxygen-carrying and oxygen-supplying capacity, can easily cause body organ failure; (3) increased incidence of diarrhea, edema, white muscle disease, etc., slow growth, rough back hair, pale skin and mucous membranes, and loss of appetite; ( 4) Physiological function decline, low immunity, susceptibility to infection and secondary diseases

[0003] Iron dextran, which is currently used in clinical practice for piglets, is mainly iron dextran. Although this drug is effective in treating iron deficiency anemia in piglets, it has the following problems for long-term application: the synthesis of iron dextran is a very complicated process, and trivalent It is prepared by the complexation reaction between iron hydroxide and dextran molecules. The complexation reaction is very unstable and is affected by the pH value of the reaction system and FeCl 3 The concentration of the solution has a great influence, the product yield is low, the quality is poor, and the raw material cost of dextran is high, resulting in the high price of the finished drug, which affects its clinical application to a certain extent

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