Preparation method for iron sucrose bulk drug and injection thereof

Abstract

The invention relates to a preparation method for an iron sucrose bulk drug. The method comprises the following steps: (1) crystallization: the pH value of sucrose solution is adjusted to 1-4 with acetic acid, iron salt solution is added to the sucrose solution to form mixed liquor, the pH value of the mixed liquor is adjusted to 1-3 with Na2CO3 solution, then the mixed liquor is stirred and is continued to be added with the Na2CO3 solution until turbidity appears in the mixed liquor, the pH value of the mixed liquor is adjusted to 4-7, and then the mixed liquor is filtered and added with water to obtain iron cake solution; (2) complexing: the sucrose solution is heated and added with alkaline liquor for alkalization, and then the alkalized sucrose solution is added with the iron cake solution and stands for the night to obtain complexing solution; and (3) refining: the complexing solution after standing for the night is filtered, and the filtrate precipitates with 2-3 times of 95 percent of ethanol and is filtered to obtain the iron sucrose bulk drug. The invention has the advantages of simple process steps, easy control of the reaction processes, good product quality, high yieldand lower production cost and is a high-novelty preparation method for the iron sucrose bulk drug and the injection thereof.

Description

technical field [0001] The invention belongs to the field of iron supplements for piglets in the animal husbandry industry, in particular to a preparation method of an iron sucrose raw material drug and an injection. Background technique [0002] In the feeding process of piglets, the intake of iron is very important. Iron is a trace element necessary for the body. It is an essential component for the body to synthesize hemoglobin. It is also myoglobin, cytochrome, and cytochrome. Components such as enzymes and peroxidases. Primary iron deficiency can cause anemia in newborn piglets. According to statistics, about 30% of piglets die due to iron deficiency. Piglets suffering from anemia mainly occur at the age of 2 to 4 weeks, and the faster the piglets grow, the more iron they store. The faster the amount is consumed, the higher the incidence of anemia. If the iron element is not supplemented in time, it will bring the following unfavorable factors to piglets: (1) cannot f...

AI Technical Summary

Problems solved by technology

If the iron element is not supplemented in time, it will bring the following unfavorable factors to piglets: (1) cannot form hemoglobin, myoglobin, cytochrome enzymes and various peroxidases, thereby affecting the delivery of nutrients in the body; (2) Low hemoglobin content, low oxygen-carrying and oxygen-supplying capacity, can easily cause body organ failure; (3) increased incidence of diarrhea, edema, white muscle disease, etc., slow growth, rough back hair, pale skin and mucous membranes, and loss of appetite; ( 4) Physiological function decline, low immunity, susceptibility to infection and secondary diseases

[0003] Iron dextran, which is currently used in clinical practice for piglets, is mainly iron dextran. Although this drug is effective in treating iron deficiency anemia in piglets, it has the following problems for long-term application: the synthesis of iron dextran is a very complicated process, and trivalent It is prepared by the complexation reaction between iron hydroxide and dextran molecules. The complexation reaction is very unstable and is affected by the pH value of the reaction system and FeCl 3 The concentration of the solution has a great influence, the product yield is low, the quality is poor, and the raw material cost of dextran is high, resulting in the high price of the finished drug, which affects its clinical application to a certain extent

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