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Acyclovir sustained-release preparation composition and method for preparing the same

A technology for sustained-release preparations and compositions, applied in the field of medicine, can solve problems such as poor patient compliance, and achieve the effects of delaying release rate, improving compliance, process quality controllability and good stability

Inactive Publication Date: 2009-08-12
山东淄博新达制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to overcome the disadvantages of acyclovir taking medicine for many times a day, resulting in poor patient compliance, the invention provides acyclovir sustained-release preparation

Method used

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  • Acyclovir sustained-release preparation composition and method for preparing the same
  • Acyclovir sustained-release preparation composition and method for preparing the same
  • Acyclovir sustained-release preparation composition and method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Sustained Release Capsules

[0025] prescription:

[0026]

[0027] Preparation Process:

[0028] Acyclovir, hydroxypropyl methylcellulose, ethyl cellulose, lactose, and magnesium stearate were respectively passed through an 80-mesh sieve, and acyclovir, hydroxypropyl methylcellulose, ethyl cellulose, and ethyl cellulose were weighed according to the prescription amount. Base cellulose, lactose, and magnesium stearate are placed in a mixer and mixed evenly, and an appropriate amount of 4% polyvinylpyrrolidone ethanol solution is used to make soft materials, and granulated in a granulator. The granules prepared above were dried at 60° C. for 1.5 h. Then pass through a swinging granulator, and use a 20-mesh sieve to sieve the granules. The content of the mixed granules is measured, and the capacity range of the ordinary hard capsule shell is determined to be filled, and the package is packaged after passing the inspection.

[0029] The aciclovir sustained-release c...

Embodiment 2

[0031] Sustained Release Pellet Capsules

[0032] Prescription: vegetarian granules

[0033]

[0034]

[0035] Prescription: Sustained-release coating solution

[0036] 15 parts of hydroxypropyl methylcellulose

[0037] 3 parts propylene glycol

[0038] Titanium dioxide 2 parts

[0039] Sodium Lauryl Sulfate 1 part

[0040] Talc powder 2 parts

[0041] Appropriate amount of water

[0042] Preparation Process:

[0043] Pass acyclovir, polyvinylpyrrolidone, microcrystalline cellulose, sucrose powder, and magnesium stearate through a 120-mesh sieve respectively, and weigh acyclovir, polyvinylpyrrolidone, microcrystalline cellulose, sucrose powder, After the magnesium stearate is placed in a mixer and mixed evenly, it is placed in a centrifugal granulator, and 80% ethanol is sprayed into the plain granules, and the coating liquid is prepared according to the prescription of the slow-release coating solution to coat the plain granules. The content of the granules is d...

Embodiment 3

[0046] sustained release granules

[0047] prescription:

[0048] Aciclovir 400.0g

[0049] Hydroxypropyl ethyl cellulose 45.0g

[0050] Ethyl cellulose 10.0g

[0051] Starch 37.0g

[0052] Magnesium Stearate 5.0g

[0053] 30% polyvinylpyrrolidone ethanol solution appropriate amount

[0054] Make 1000 bags

[0055] Preparation Process:

[0056]Pass acyclovir, hydroxypropyl ethyl cellulose, ethyl cellulose, starch and magnesium stearate through 80 mesh sieves respectively, and weigh acyclovir, hydroxypropyl ethyl cellulose, ethyl cellulose according to the prescription amount. Base cellulose, starch, and magnesium stearate are placed in a mixer and mixed evenly, and an appropriate amount of 30% polyvinylpyrrolidone ethanol solution is used to make soft materials, and granulated in a granulator. The granules prepared above were dried at 60° C. for 1.5 h. Then pass through a swinging granulator, and use a 20-mesh sieve to sieve the granules. The content of the granules ...

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Abstract

The invention discloses a group of acyclovir sustained-release preparation combinations and a preparation method thereof. The group of acyclovir sustained-release preparation combinations is mainly prepared from acyclovir bulk drugs, medicinal sustained-release materials and other appropriate auxiliary materials. The acyclovir enteric sustained-release preparation provided by the invention can deaccelerate the release rate of main drugs, reduce the frequency of administration and improve the patient compliance. The acyclovir sustained-release preparation combination provided by the invention has the advantages of high quality controllability and stability of the preparation process.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a group of acyclovir sustained-release preparation compositions and a preparation method thereof. Background technique [0002] Acyclovir is a purine nucleoside derivative, which is currently under the control of over-the-counter drugs. According to reports, acyclovir has inhibitory effects on herpes simplex virus type I (HSV-1), type H (HSV-2) and varicella-zoster virus (VZV) both in vivo and in vitro. The result of cell culture shows that this product has the strongest inhibitory effect on HSV-1 virus, followed by HSV-2 and VZV virus. Due to the affinity of this product to thymidine kinase (TK) encoded by HSV and VZV, it has highly selective inhibitory effect. These viral enzymes convert loratadine to acyclovir monophosphate, a nucleoside analog. Monophosphate is further converted to diphosphate by guanylate kinase in the cell, and then converted to triphosphate by various en...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61K9/00A61K9/48A61P31/12
Inventor 贺同庆贾法强安英张慧英张玲玲
Owner 山东淄博新达制药有限公司
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