The invention relates to a medicinal and edible composition for synergistically improving AD cognitive and affective disorders through three pathways, and belongs to the technical field of medicines. The composition comprises the following raw materials: 6-8 parts of
ginseng, 4-6 parts of
hovenia dulcis thunb, 4-6 parts of folium cortex eucommiae, 3-7 parts of lucid
ganoderma, 1-3 parts of longan
aril and 1-3 parts of liquorice.
Ginseng and lucid
ganoderma are used as monarch drugs to mainly tonify the
kidney and nourish the heart;
hovenia dulcis thunb or
ampelopsis grossedentata leaves and folium cortex eucommiae are used as ministerial drugs and are mainly used for removing internal heat and tranquilizing mind and strongly inhibiting
neuroinflammation and
oxidative stress; the longan
aril and the liquorice are used as assistant and conductant drugs to fix and protect the
spleen and
stomach and regulate the
drug property. The preparation method comprises the following steps: compounding
powder prepared by adopting a bacterium-
enzyme combination technology and a
phospholipid / beta-
cyclodextrin embedding technology according to a ratio, and adding
ergothioneine as required. According to the application disclosed by the invention, three pathways of beta
amyloid protein deposition,
Tau protein excessive
phosphorylation and
neuroinflammation are synergistically regulated and controlled, so that
learning memory and cognitive dysfunction and related emotion and
sleep disorder symptoms caused by AD and vascular
dementia can be effectively intervened.