Clary injection and its preparation method

A technology of injection and Xiangdan, which is applied in the direction of liquid transportation, pharmaceutical formula, emulsion transportation, etc., can solve the problems of turbidity, precipitation, and affecting product quality of liquid medicine, and achieve the goals of increasing stability, avoiding degradation, and prolonging the validity period of quality Effect

Inactive Publication Date: 2006-09-13
诺氏制药(吉林)有限公司
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  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Xiangdan injection is a pure traditional Chinese medicine preparation, which is prone to turbidity, precipitation, and discoloration during storage, which will affect product quality. The validity period is only two years

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take 1000g of balsamic, add purified water 3 times the weight of the medicinal material, and use steam distillation to collect the distillate, which is 1 / 2 of the medicinal material, refrigerate the distillate for 24 hours, separate to remove the oil layer, filter through filter paper, and obtain the balsamic aromatic water, which is set aside; Decoct 1000g of Danshen medicinal material with purified water of 8, 6, and 6 times the weight of the medicinal material for 3 times, for 2 hours for the first time, 1.5 hours for the second time, and 1.5 hours for the third time, filter, combine the filtrate, concentrate the filtrate, and add to the concentrated solution Add 0.06% of the weight of the concentrated solution to clarifier B, heat to 70-90°C, let it stand for 2 hours, then add 0.03% of the weight of the concentrated solution to clarify agent A, after standing for 4 hours, centrifuge, and the supernatant Pour out and concentrate to 4g of crude drug per ml of liquid me...

Embodiment 2

[0018] Take 500 g of balsamic, add purified water 5 times the weight of the medicinal material, collect the distillate by steam distillation to be 1 / 3 of the medicinal material, refrigerate the distillate for 24 hours, separate to remove the oil layer, filter with filter paper, and obtain the balsamic aromatic water, which is set aside; Decoct 800g of Danshen medicinal material with purified water of 8, 5, and 5 times the weight of the medicinal material for 3 times, the first time for 2 hours, the second time for 1.5 hours, and the third time for 1.5 hours, filter, combine the filtrates, concentrate the filtrates, and pour into the concentrated solution Add 0.05% of the weight of the concentrate to clarifier B, heat it to 70-90°C, let it stand for 2 hours, then add 0.025% of the weight of the concentrate to clarify agent A, let it stand for 4 hours, centrifuge, and the supernatant Pour out and concentrate to 4g of crude drug per ml of liquid medicine; add ethanol under slow st...

Embodiment 3

[0020] Take 300 g of balsamic, add purified water 4 times the weight of the medicinal material, and collect the distillate by steam distillation to be 1 / 2 of the medicinal material, refrigerate the distillate for 24 hours, separate to remove the oil layer, filter through filter paper, and obtain the balsamic aromatic water, which is set aside; Decoct 500g of Danshen medicinal material with purified water of 8, 6, and 6 times the weight of the medicinal material for 3 times, for 2 hours for the first time, 1.5 hours for the second time, and 1.5 hours for the third time, filter, combine the filtrates, concentrate the filtrates, and pour into the concentrated solution Add 0.04% of the weight of the concentrate to clarifier B, heat it to 70-90°C, let it stand for 2 hours, then add 0.02% of the weight of the concentrate to clarify agent A, let it stand for 4 hours, centrifuge, and the supernatant Pour out and concentrate to 4g of crude drug per ml of medicinal solution; add ethanol ...

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PUM

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Abstract

A Chinese medicine 'Xiangdan injection' for treating angina pectoris and myocardial infarction is prepared from red sage root and dalbergia wood through preparing the aromatic liquid by distilling dalbergia wood, preparing liquid extract of red sage root through depositing in alcohol and water, centrifugal separation and ultrafiltration, mixing them together, stirring, loading in containers and sterilizing.

Description

field of invention [0001] The invention relates to a Xiangdan injection and a preparation method thereof, belonging to the field of traditional Chinese medicine preparations. Background technique [0002] Salvia miltiorrhiza is the root of Salvia miltiorrhiza of Lamiaceae. Bitter in the mouth, slightly cold in nature. It has the functions of promoting blood circulation and removing blood stasis, nourishing blood and calming the nerves, cooling blood and eliminating carbuncle, and promoting granulation. The main ingredients are divided into two types: fat-soluble ingredients and water-soluble ingredients. The fat-soluble ingredients are mainly: tanshinone, cryptotanshinone, tanshinol, Tanshinone, etc. The main water-soluble ingredients are: Danshensu, salvianic acid A, B, C, protocatechualdehyde and so on. The water-soluble components of Danshen can significantly expand coronary arteries, significantly increase coronary blood flow, and promote collateral circulation; it ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/10A61P9/10
Inventor 郭智华
Owner 诺氏制药(吉林)有限公司
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