Method for computing FFR<CT> (fractional flow reserve <computed tomography>) on basis of personalized coronary artery branch blood flow volumes

Abstract

The invention discloses a method for computing FFR<CT> (fractional flow reserve <computed tomography>) on the basis of personalized coronary artery branch blood flow volumes, and belongs to the field of biomechanics and haemodynamics. The method includes clinically acquiring physiological parameters of cardiac muscle masses, heart rates, blood pressures and the like of patients and establishing coronary blood flow volume computing empirical formulas on the basis of allometric growth laws; rebuilding three-dimensional geometric models of coronary arteries on the basis of CT images of the coronary arteries of the patients, acquiring the volumes of blood vessels of branches of the coronary arteries and the vessel diameters of the various branches and acquiring split ratios of the various branches on the basis of the volumes of the blood vessels of the branches and the Poiseuille law; combining the coronary blood flow volumes of the patients and the split ratios of the various branches with one another, acquiring the blood flow volumes of the various branches of the coronary arteries by means of computing and solving the FFR<CT> of the coronary arteries of the patients by the aid of the blood flow volumes of the various branches of the coronary arteries. The blood flow volumes of the various branches of the coronary arteries are used as coronary haemodynamics computing boundary conditions. The method has the advantages that FFR of the coronary arteries of human bodies can be noninvasively computed, simulation results can be similar to real blood flow states under the condition of the maximum congestion states of the coronary arteries of the patients owing to personalized coronary flow boundaries, and accordingly the coronary artery FFR<CT> computing accuracy can be improved.

Description

technical field [0001] The present invention relates to the fields of biomechanics and hemodynamics, in particular to a hemodynamic numerical simulation technology, which can be used for setting individualized boundary conditions in the simulation calculation of human coronary artery hemodynamics, and then realizes FFR CT Numerical simulation calculations. Background technique [0002] Coronary FFR technology is currently the "gold standard" clinically used to diagnose whether coronary stenosis causes downstream myocardial ischemia. FFR CT technology. coronary FFR CT The technology is based on the patient's coronary CT images, using numerical simulation methods to realize the hemodynamic simulation of the coronary arteries, and non-invasively obtaining the FFR value by extracting the upstream and downstream pressure values ​​of the stenotic coronary arteries, that is, FFR CT value. in FFR CT In the technology, the quality of coronary three-dimensional model reconstruct...

AI Technical Summary

Problems solved by technology

The blood flow distribution method based on the length of branch vessels may ignore the difference in the shunt volume of vessels with the same length but different diameters, while the blood flow distribution method based on vessel diameters is more difficult in issues such as the diameter measurement position and the classification of branch vessels. complex, difficult to regularize

Therefore, considering any of these factors alone may cause errors

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