Related ingredient combination with function of relaxing vessels in traditional Chinese medicine for reducing blood pressure
A technique for dilating blood vessels and lowering blood pressure, which is applied to medical preparations containing active ingredients, organic active ingredients, and pharmaceutical formulas, and can solve problems such as difficult quality control, restrictions on the promotion and use of blood pressure-lowering traditional Chinese medicines, and large gaps in therapeutic effects. To achieve the effect of avoiding side effects
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Embodiment 1
[0020] Embodiment 1: Composition (active ingredient type=2) preparation
[0021] Method a: combine the two active ingredients in a weight ratio of 1:1 to obtain a compatibility.
[0022] Method b: On the premise that the total amount is constant, the lowest effective dose of each active ingredient is used as the benchmark, during which each ingredient is decreased or increased by 20%, and finally expanded to the extreme of high dose.
[0023] Using the rat thoracic aortic ring model and the SHR model, the best compatibility ratio was screened out.
Embodiment 2
[0024] Embodiment 2: preparation of composition (active component type≤6)
[0025] Method a: Combination of 3 ingredients. Three kinds of active ingredients and five dose levels were designed according to the orthogonal test method with three factors and five levels [L25(56)], and the combinations with different dosage ratios were formed, and the rat thoracic aortic vascular ring model and SHR model were used to screen Find the best matching ratio.
[0026] Method b: Combination of 4 ingredients. 4 kinds of active ingredients and 5 dosage levels, according to the orthogonal test method design 4 factors 5 levels table [L25(56)], form the combination with different dosage ratio, use rat thoracic aortic vascular ring model, SHR model, screen Find the best matching ratio.
[0027] Method c: 5 ingredient combinations. Five kinds of active ingredients and five dose levels were designed according to the orthogonal test method with five factors and five levels [L25(56)], and the c...
Embodiment 3
[0029] Embodiment 3: Pinoresinol diglucoside, rhynchophylline, puerarin, and cassia anthraquinone were prepared according to Example 1. The composition was tested in vitro in the thoracic aorta vascular ring of rats. The vasodilation effect is as follows:
[0030] Table 1 Vasodilation effect after combination of pinoresinol diglucoside, rhynchophylline, puerarin, and cassia anthraquinone in pairs (n=6)
[0031]
[0032]
[0033] As can be seen from the above table, pinoresinol diglucoside: rhynchophylline=1:2; pinoresinol diglucoside: puerarin=1:1; pinoresinol diglucoside: cassia anthraquinone=4:1; rhynchophylline: Puerarin=4:1; rhynchophylline:cassia anthraquinone=4:1; puerarin:cassia anthraquinone=4:1 is the best compatibility ratio.
[0034] The best compatibility screened out was given to SHR rats by intragastric administration after grouping, and the systolic blood pressure of the tail artery of the rats was detected every week for a total of four weeks. The results...
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