Related ingredient combination with function of relaxing vessels in traditional Chinese medicine for reducing blood pressure

A technique for dilating blood vessels and lowering blood pressure, which is applied to medical preparations containing active ingredients, organic active ingredients, and pharmaceutical formulas, and can solve problems such as difficult quality control, restrictions on the promotion and use of blood pressure-lowering traditional Chinese medicines, and large gaps in therapeutic effects. To achieve the effect of avoiding side effects

Inactive Publication Date: 2012-10-17
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although traditional Chinese medicine compound recipes have achieved good clinical results in treating hypertension and its complications, the traditional Chinese medicine compound recipes are complex in composition and difficult to control in quality, which limit

Method used

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  • Related ingredient combination with function of relaxing vessels in traditional Chinese medicine for reducing blood pressure
  • Related ingredient combination with function of relaxing vessels in traditional Chinese medicine for reducing blood pressure
  • Related ingredient combination with function of relaxing vessels in traditional Chinese medicine for reducing blood pressure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: Composition (active ingredient type=2) preparation

[0021] Method a: combine the two active ingredients in a weight ratio of 1:1 to obtain a compatibility.

[0022] Method b: On the premise that the total amount is constant, the lowest effective dose of each active ingredient is used as the benchmark, during which each ingredient is decreased or increased by 20%, and finally expanded to the extreme of high dose.

[0023] Using the rat thoracic aortic ring model and the SHR model, the best compatibility ratio was screened out.

Embodiment 2

[0024] Embodiment 2: preparation of composition (active component type≤6)

[0025] Method a: Combination of 3 ingredients. Three kinds of active ingredients and five dose levels were designed according to the orthogonal test method with three factors and five levels [L25(56)], and the combinations with different dosage ratios were formed, and the rat thoracic aortic vascular ring model and SHR model were used to screen Find the best matching ratio.

[0026] Method b: Combination of 4 ingredients. 4 kinds of active ingredients and 5 dosage levels, according to the orthogonal test method design 4 factors 5 levels table [L25(56)], form the combination with different dosage ratio, use rat thoracic aortic vascular ring model, SHR model, screen Find the best matching ratio.

[0027] Method c: 5 ingredient combinations. Five kinds of active ingredients and five dose levels were designed according to the orthogonal test method with five factors and five levels [L25(56)], and the c...

Embodiment 3

[0029] Embodiment 3: Pinoresinol diglucoside, rhynchophylline, puerarin, and cassia anthraquinone were prepared according to Example 1. The composition was tested in vitro in the thoracic aorta vascular ring of rats. The vasodilation effect is as follows:

[0030] Table 1 Vasodilation effect after combination of pinoresinol diglucoside, rhynchophylline, puerarin, and cassia anthraquinone in pairs (n=6)

[0031]

[0032]

[0033] As can be seen from the above table, pinoresinol diglucoside: rhynchophylline=1:2; pinoresinol diglucoside: puerarin=1:1; pinoresinol diglucoside: cassia anthraquinone=4:1; rhynchophylline: Puerarin=4:1; rhynchophylline:cassia anthraquinone=4:1; puerarin:cassia anthraquinone=4:1 is the best compatibility ratio.

[0034] The best compatibility screened out was given to SHR rats by intragastric administration after grouping, and the systolic blood pressure of the tail artery of the rats was detected every week for a total of four weeks. The results...

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Abstract

The invention relates to the related ingredient combination with the function of relaxing vessels in traditional Chinese medicine for reducing blood pressure which is commonly used clinically. The invention utilizes modern traditional Chinese medicine theory and provides a related ingredient combination with definite ingredient, controllable quality and precise curative effect by animal model tests for reducing blood pressure. The related ingredient combination can be used for relaxing vessels, treating hypertension and improving hypertension complication. The commonly used traditional Chinese medicine relates to eucommia ulmoides, rhizoma gastrodiae, rhizoma chuanxiong, salviae miltiorrhizae, Astragalus mongholicus, root of kudzu vine, uncaria, radix stephaniae tetrandrae, red flower, radix scutellariae, selfheal, semen cassiae, dogbane leaf, hawthorn, radix achyranthis bidentatae, sophora flower, pseudo-ginseng, motherwort, chrysanthemum, lotus plumule, evodia, cape jasmine fruit, epimedium and caltrop which are included in Chinese Pharmacopoeia (2010 edition). The related ingredients are active ingredients which are extracted from single traditional Chinese medicine. Each traditional Chinese medicine provides one or several active ingredients. The combination study comprises the following steps of combining 2-6 active ingredients with different mechanisms in proportion, screening by utilizing rat thoracic aorta vascular rings and spontaneous hypertension rat models and determining the optimum combination proportion.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to the compatibility of related ingredients in blood pressure lowering traditional Chinese medicines which have the effect of dilating blood vessels. The compatibilized composition can be used to relax blood vessels, treat hypertension and improve hypertension complications. Background technique [0002] Hypertension and cardiovascular and cerebrovascular diseases related to hypertension are one of the main killers that endanger public health, and their incidence is increasing year by year. Effective prevention and treatment of them has become a public health problem of common concern worldwide. Although the current antihypertensive drugs can effectively control blood pressure, due to the different mechanisms of blood pressure rise in patients, a single drug is often unable to control it, and a combination of drugs is required. After combined medication, each antihyperte...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61K36/482A61K31/7048A61P9/12A61K31/437A61K31/4965A61K31/352A61K31/7034
Inventor 许激扬卞筱泓赵刚刚周恒源王旻
Owner CHINA PHARM UNIV
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