6 results about "Oseltamivir Phosphate" patented technology

This invention discloses an oseltamivir phosphate capsule and its preparation method, relating to the field of pharmaceutical formulation technology, including the following steps: (1) placing oseltamivir phosphate, filler, disintegrant, and binder in a wet granulation mixer and mixing them evenly; (2) dispersing mannitol and mesoporous polydopamine nanoparticles in purified water to form a mixed dispersion; (3) adding the mixed dispersion obtained in step (2) to a wet granulation mixer for wet granulation and drying to obtain a premix; (4) mixing the premix obtained in step (3) with a lubricant evenly to obtain a mixture; (5) filling the mixture obtained in step (4) into a soft capsule shell to obtain an oseltamivir phosphate capsule; This invention, by using mesoporous polydopamine nanoparticles and mannitol to synergistically prepare a wetting solution for wet granulation, can effectively improve the dissolution stability of oseltamivir phosphate capsules, maintaining high dissolution even after long-term storage, thus improving the stability of the drug.

The present application relates to oseltamivir phosphate single crystal and its preparation method. The present application selects specific mixed solvent to slowly evaporate to obtain needle-like crystal, which is the first successful preparation of oseltamivir phosphate single crystal in the world. The oseltamivir phosphate single crystal prepared by the present application has the chemical formula of C 16 H 31 N2O8P, a molecular weight of 410.40, and a crystal structure belonging to orthorhombic system, a space group of P21212, a=23.9002(6)Å, b=24.4812(6)Å, c=7.4191(2)Å, α=90°, β=90°, γ=90°, V=4340.96(19)Å 3 , Z=8. The preparation and determination of the single crystal have important significance and application value for the structure-activity relationship study of oseltamivir phosphate drug and new drug development.

The application discloses a human rhubarb extract with anti-influenza A virus activity and a preparation method thereof. The preparation method comprises the following steps: preparing the human rhubarb by fermenting licorice with an artificial synthetic flora (15 kinds of probiotics are mixed according to a specific ratio), and then performing ultrasonic extraction with water as a solvent; and the optimized extraction conditions are as follows: a solid-liquid ratio of 1:30 g / mL, an ultrasonic power of 500 W, an ultrasonic temperature of 50 DEG C, an ultrasonic time of 35 min, and an extraction frequency of 2 times. Compared with traditional extraction and decoction methods, the extract yield is higher, the inhibitory effect on H1N1 influenza A virus is significantly enhanced, the blood clotting titer of mouse lung tissue is reduced to 0.6+ / -0.4, and is equivalent to that of the positive drug oseltamivir phosphate. The application avoids the risk of pathogenic microorganism pollution in traditional pit fermentation, simplifies the medication mode, realizes the reduction and efficiency increase, the process is stable and controllable, is suitable for industrial production, and provides technical support for modern anti-influenza application of the human rhubarb.

1. The name of the design product: packaging box (oseltamivir phosphate capsules 2). 2. The use of the design product: the design product is used for the packaging and protection of medicines. 3. The design points of the design product: in the pattern. 4. The picture or photo that best indicates the design points: perspective view.