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Oseltamivir phosphate dry powder inhalations and preparation method thereof

A technology of oseltamivir phosphate and inhalation powder, which is applied in the field of oseltamivir phosphate inhalation powder and its preparation, and can solve the problems of digestive tract discomfort, oseltamivir not being able to accumulate in the lungs, and restrictions

Inactive Publication Date: 2011-10-26
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Influenza A (H1N1) virus that broke out in 2009 is resistant to these two drugs, making this type of drug subject to many restrictions in the treatment of influenza A (H1N1)
[0009] In the existing oral administration method, oseltamivir cannot be effectively enriched in the lungs, and only less than 10% of the drug is distributed to the lungs
And it has been reported that oral administration of oseltamivir may cause discomfort in the digestive tract, including nausea, vomiting, diarrhea, abdominal pain, etc., as well as adverse reactions in the central nervous system, such as dizziness, headache, insomnia, fatigue, etc.

Method used

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  • Oseltamivir phosphate dry powder inhalations and preparation method thereof
  • Oseltamivir phosphate dry powder inhalations and preparation method thereof
  • Oseltamivir phosphate dry powder inhalations and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Name of raw material Amount (g)

[0061] Oseltamivir Phosphate 0.6

[0062] Threonine 0.4

[0063] The above raw and auxiliary materials were dissolved in 100 mL deionized water, and spray-dried. The spray drying conditions were as follows: an inlet temperature of 100°C, an infusion pump speed of 2 mL / min, and an atomizing air flow rate of 700 L / h. Collect the powder in the cyclone separator and store it in a desiccator.

Embodiment 2

[0065] Name of raw material Amount (g)

[0066] Oseltamivir Phosphate 0.8

[0067] Leucine 0.2

[0068] The above raw and auxiliary materials were dissolved in 100 mL deionized water, and spray-dried. The spray drying conditions were as follows: an inlet temperature of 140°C, an infusion pump speed of 3 mL / min, and an atomizing air flow rate of 600 L / h. Collect the powder in the cyclone separator and store it in a desiccator.

Embodiment 3

[0070] Name of raw material Amount (g)

[0071] Oseltamivir Phosphate 0.7

[0072] Arginine 0.3

[0073] The above raw and auxiliary materials were dissolved in 100 mL deionized water, and spray-dried. The spray drying conditions were as follows: an inlet temperature of 110°C, an infusion pump speed of 2 mL / min, and an atomizing air flow rate of 400 L / h. Collect the powder in the cyclone separator and store it in a desiccator.

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Abstract

The invention relates to the field of pharmaceutical preparations, and particularly relates to oseltamivir phosphate dry powder inhalations for treating influenza A and influenza B and a preparation method thereof. The oseltamivir phosphate dry powder inhalations are characterized in that the inhalations comprise oseltamivir phosphate and a co-atomizing agent in a weight ratio of (8:2)-(6:4). The oseltamivir phosphate dry powder inhalations provided by the invention have a simple preparation method, good fluidity, and good stability. After administration, the medicine can be metabolized to metabolites with anti-influenza virus activity, which can take an antibacterial effect and be used for preventing and treating influenza A and influenza B.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a drug oseltamivir phosphate inhalation powder for anti-influenza A and type B and a preparation method thereof. Background technique [0002] Influenza is an acute respiratory infectious disease caused by influenza virus, and its incidence rate is the first among various infectious diseases. According to the antigenicity of nucleoprotein and matrix protein of influenza virus, influenza virus is divided into three serotypes: A, B, and C. [0003] Among them, the surface glycoprotein of influenza A virus has higher variability. Influenza A virus is divided into different subtypes according to the antigenicity of viral hemagglutinin (HA) and neuraminidase (Neuraminidase, NA). So far, at least 16 kinds of HA have been found, named after H1-H16, and at least 9 kinds of NA, named after N1-N9. The combination of H1-H16 and N1-N9 can produce more than 100 subtypes, and the ...

Claims

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Application Information

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IPC IPC(8): A61K9/72A61K31/661A61K31/215A61K47/16A61K47/26A61P31/16
Inventor 汤玥姜力群鲁锡峰朱家壁
Owner CHINA PHARM UNIV
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