Improved oseltamivir phosphate medicinal composition

A technology of oseltamivir phosphate and composition, which is applied in the direction of non-active ingredients of polymer compounds, pharmaceutical formulations, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2011-05-25
李春娟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The vast majority of adverse events did not

Method used

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  • Improved oseltamivir phosphate medicinal composition

Examples

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Comparison scheme
Effect test

Embodiment 1

[0059] Embodiment 1: the preparation of oseltamivir phosphate pharmaceutical composition

[0060] Element

[0061] Grind oseltamivir phosphate and cyclodextrin through a 100-mesh sieve, accurately weigh the prescribed amount of oseltamivir phosphate, cyclodextrin and 30ml of water, mix evenly, grind, and vacuum dry to remove moisture; In plastic bottles, each bottle contains 600mg of oseltamivir phosphate, ready to use.

Embodiment 2

[0062] Embodiment 2: the preparation of oseltamivir phosphate pharmaceutical composition

[0063] Element

[0064] Grind oseltamivir phosphate and cyclodextrin through a 100-mesh sieve, accurately weigh the prescribed amount of oseltamivir phosphate, cyclodextrin and 15ml of water, mix well, grind, and vacuum dry to remove moisture; In plastic bottles, each bottle contains 600mg of oseltamivir phosphate, ready to use.

Embodiment 3

[0065] Embodiment 3: the preparation of oseltamivir phosphate pharmaceutical composition

[0066] Element

[0067] methyl-beta cyclodextrin

[0068] Grind oseltamivir phosphate and cyclodextrin through a 100-mesh sieve, accurately weigh the prescribed amount of oseltamivir phosphate, cyclodextrin and 450ml of water, mix well, grind, and vacuum dry to remove moisture; In plastic bottles, each bottle contains 600mg of oseltamivir phosphate, ready to use.

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PUM

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Abstract

The invention provides an improved oseltamivir phosphate medicinal composition, which comprises an effective amount of oseltamivir phosphate for treating or preventing diseases, at least one beta cyclodextrin or cyclodextrin derivative and one or more optional pharmaceutically acceptable excipients. The invention also provides the application of a solid medicinal composition to the preparation of an oral liquid medicament. The invention further provides a liquid medicinal composition which comprises the medicinal composition and a water-containing medium. The medicinal composition has an excellent effect as specified in the specifications.

Description

technical field [0001] The invention relates to a novel pharmaceutical composition of improved oseltamivir phosphate. Background technique [0002] Neuraminidase (NA) inhibitors are a class of anti-influenza virus drugs developed in recent years. As a newly developed neuraminidase inhibitor, oseltamivir phosphate is effective against both type A and type B influenza viruses, It is not easy to drug resistance, well tolerated by patients, and has high safety. It is clinically used for the prevention and treatment of influenza. [0003] Oseltamivir (Oseltamivir, used as its phosphate salt) is a therapeutic drug for the prevention and control of influenza pandemics by the World Health Organization and the Ministry of Health of my country, and it is also a national strategic reserve drug for the prevention and control of influenza pandemics in my country and other countries in the world. [0004] At present, the commercially available dosage form of oseltamivir phosphate in my c...

Claims

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Application Information

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IPC IPC(8): A61K31/215A61K47/40A61K9/10A61P31/16
Inventor 李春娟
Owner 李春娟
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