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Compound traditional Chinese medicine extract preventing glucose metabolism disturbance and preparation method thereof

A technology for compound traditional Chinese medicines and extracts, applied in metabolic diseases, drug combinations, medical preparations containing active ingredients, etc., can solve the problems of unclear active ingredients, complex chemical components, difficult product quality, etc., and achieve controllable product quality. , The effect of stable preparation process and increased content of active ingredients

Active Publication Date: 2011-07-27
青岛百里才鑫医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the problems of complex chemical components, unclear active ingredients, difficult to effectively control the product quality in practical application, and too many invalid components in the existing compound traditional Chinese medicine for preventing or treating blood sugar metabolism disorders. , providing a compound traditional Chinese medicine extract for preventing and treating glucose metabolism disorders

Method used

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  • Compound traditional Chinese medicine extract preventing glucose metabolism disturbance and preparation method thereof
  • Compound traditional Chinese medicine extract preventing glucose metabolism disturbance and preparation method thereof
  • Compound traditional Chinese medicine extract preventing glucose metabolism disturbance and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Preparation of the total extract (FTZ) of the compound Chinese medicine

[0028] Combine the two medicines of Ligustrum lucidum, Atractylodes macrocephala, Eucommia ulmoides, Panax notoginseng, Daji, Salvia miltiorrhiza, Coptis chinensis, and bergamot (weight ratio 1:1:1:2:1:2:1:1) Crushed into coarse powder, reflux extraction with 60% ethanol of 12 times, 10 times and 8 times the amount of medicinal material respectively, each time for 2 hours, combine the extracts, recover the ethanol and make the concentration of the alcohol extraction part 1 ml equivalent to 1 g crude drug; the rest of the medicinal materials in the prescription were decocted and extracted three times with 12 times, 10 times and 8 times the amount of water respectively, each time for 2 hours, combined three water extracts, and concentrated under vacuum to 1 g medicinal materials / ml extract , the water extraction part and the previous alcohol extraction part were combined to obtain the tot...

Embodiment 2

[0029] Example 2 The preparation of the extraction part of the compound total extract

[0030] Extract once with petroleum ether of 5 times the volume of the total compound extract, and separate the petroleum ether layer; then extract twice with 3 times the volume, separate and obtain the petroleum ether layer, combine the petroleum ether extracts three times, recover petroleum ether, and then , dried under vacuum at 65°C to obtain the effective extraction part A;

[0031] Add 10, 8, and 5 times the amount of ethyl acetate to the remaining extracts after extraction, respectively, and extract the obtained ethyl acetate extraction sites, recover the solvent, and dry them under vacuum at 0.07 MPa and 75°C to obtain effective extraction sites B;

[0032] After ethyl acetate extraction, the remaining extracts were extracted with 10, 6, and 3 times the amount of n-butanol of the total extract respectively, and the obtained extracts were combined to recover n-butanol. Vacuum dryin...

Embodiment 3

[0038] Embodiment 3 The preparation method of extract composition capsule

[0039] The extracts are combined according to the following parts by weight:

[0040] Effective extraction part A 1 part

[0041] 2 copies of effective extraction part B

[0042] 5 copies of effective extraction part C

[0043] Mix the extracts in the above proportions, the effective extraction part A with the same amount of starch, and then mix it with the effective extraction part B, and finally mix it with the effective extraction part C. After the three are mixed evenly, dry granulation is performed, and after drying under reduced pressure, Whole grains, filled with No. 2 capsules, polished, and packaged for quality inspection.

[0044] Measure the capsule that makes with HPLC method, it contains each active ingredient content result and sees Table 1:

[0045] Table 1 HPLC determination results of FTZCE capsules

[0046]

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Abstract

The invention discloses a compound traditional Chinese medicine extract preventing glucose metabolism disturbance, comprising the following effective ingredients: dried alcohol, Beta-sitosterol, hexacosanoic acid, butenolide III, oleanolic acid, berberine, jateorhizine, coptisine, salvianic acid A, salvianolic acid B, ring-tetracosane, 9,12-octadecadienoic acid, 5,7-dimethoxy coumarin, specnuezhenide, ginsenoside Rb1 and Rg1, notoginsenoside R1 and encommiol. A preparation method of the extract is as follows: extracting raw material medicines by C1-3 alcohol and / or water, combining a total extract, extracting the total extract by organic solvents with different polarities so as to obtain all effective ingredients, and finally mixing the ingredients so as to obtain a product. As for the compound traditional Chinese medicine extract, a large number of ineffective chemical ingredients in Chinese medicine are removed, so that the content of effective ingredients is increased greatly, and the influence on product processing and preparation quality caused by the ineffective ingredients is reduced; and simultaneously, the preparation process is stable, the product quality is controllable, the mass production is facilitated, and the drug effect of the compound traditional Chinese medicine is improved.

Description

technical field [0001] The invention relates to the field of compound traditional Chinese medicines, in particular to a compound traditional Chinese medicine extract for preventing and treating carbohydrate metabolism disorders and a preparation method thereof. Background technique [0002] Diabetes is a metabolic disease caused by disorders of blood sugar metabolism. Diabetes has become a major threat to human health in contemporary society, which has attracted the attention of WHO and governments of various countries, and is a hot spot in medical research. But so far, the pathogenesis of blood sugar metabolism disorder has not been elucidated, and there is no ideal method for clinical treatment of diabetes. Although chemical drugs have many drugs for lowering blood sugar, their comprehensive curative effect is not ideal, and chemical drugs also have problems such as adverse reactions and high cost of medication, which are also the disadvantages of chemical drugs. [0003...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/704A61K31/575A61K31/56A61K31/4375A61K31/352A61K31/343A61K31/201A61K31/20A61K31/192A61K31/015A61K36/752A61P3/10
CPCA61K36/537A61K31/047A61K31/201A61K31/20A61K31/37A61K31/015A61K36/638A61K36/284A61K36/258A61K31/365A61K31/192A61K36/718A61K31/045A61K31/4375A61K31/575A61K36/28A61K31/7048A61K36/752A61K36/46A61K31/343A61K31/56A61P3/10A61K2300/00
Inventor 郭姣贝伟剑
Owner 青岛百里才鑫医药科技有限公司
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