Aliphatic organic acid salt of berberine type alkaloid and preparation method and usage thereof

A technology of organic acid salts and alkaloids, which is applied in the field of pharmacy, can solve problems such as drug accumulation, and achieve the effects of improved bioavailability, good therapeutic effect, and high bioavailability
CN101113149AInactive Publication Date: 2008-01-30FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUDAN UNIV
Publication Date
2008-01-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to preparation method and application of berberine fatty group organic acid salt, pertaining to pharmacy field. The chemical general formula of barberine type alkaline of the invention is shown as a formula (I), wherein, X represents organic acid group, and the berberine type alkaline is berberin, palmatine, jaterohitine or coptisine. The invention relates berberine alkaline fatty group organic acid, which is of good oral taking absorption, can be used for preparing medical components, greatly improves the bio-availability of the alkaline type, and play comparatively better effect to the therapies of such diseases as bacterial infection, heart rate abnormity, platelet aggregation, hyperlipidemia, diabetes, hypertension, cardiac failure, etc.
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Description

Technical field

[0001] The invention belongs to the field of pharmacy, and relates to aliphatic organic acid salts of berberine alkaloids, and a preparation method, medicinal composition and application thereof. Background technique

[0002] Berberines (berberines) alkaloids include berberine (berberine), palmatine (palmatine), jatrorrhizine (jatrorrhizine) and coptisine (coptisine). Berberine alkaloids have long been used clinically as antibacterial drugs, mainly for the treatment of diseases such as gastroenteritis and bacillary dysentery. In recent years, the new pharmacological effects of this type of alkaloids have been gradually discovered, which has attracted the attention of researchers again. The most extensive and in-depth research is its representative alkaloid-berberine. There are many reports on the pharmacological research of berberine in domestic and foreign journals, including the lipid-lowering effect and mechanism reported by Chinese scholars in Nature Medicine....

Claims

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