The invention discloses a liver-protection tea powder prepared from radix puerariae and flammulina velutipes and a preparation method thereof. The liver-protection tea powder is prepared from the following materials in parts by weight: 60-80 parts of flammulina velutipes, 8-15 parts of radix puerariae powder, 10-15 parts of melon, 10-14 parts of vicia unijuga, 6-10 parts of burdock powder, 8-10 parts of okra, 10-15 parts of pinenut, 8-12 parts of prickly pear fruit, 10-15 parts of red fragrant rice, 5-8 parts of bamboo juice, 1-2 parts of adonis flower, 2-3 parts of perilla frutescens seeds, 1-2 parts of piper wallichii, 1-2 parts of chrysanthemum nankingense flower , 1-2 parts of penthorum chinense pursh, 1-2 parts of Aglaia odorata, 40-80 parts of mulberry wine and 6-10 parts of nutrient and health-care powder. The liver-protection tea powder provided in the invention is fragrant, mellow and sweet in taste and is rich and balanced in nutrition. Lyophilized flammulina velutipes is adopted to absorb the nutrient and functional components of the mulberry wine so that functions of nourishing body, strengthening body and benefiting liver are achieved. In addition, through the synergistic effects of the mulberry wine with many other traditional Chinese medicine components having efficacies of clearing away toxic materials, adjusting liver function and nourishing and protecting liver, the recovery function of the liver is enhanced, and the disease-resistant ability of a human body is improved.