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Methods and compositions for recovery from stroke

A composition and a technology for restoring function, which are applied in the field of drugs for promoting recovery of functions, drugs for nerve function recovery, and p38-αMAPK inhibitors in subjects, which can solve the problems of unsuccessful drug preparations and the like

Inactive Publication Date: 2018-07-31
EIP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To date, no pharmaceutical formulation has been successfully developed as a treatment to promote neurological recovery after stroke

Method used

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  • Methods and compositions for recovery from stroke
  • Methods and compositions for recovery from stroke
  • Methods and compositions for recovery from stroke

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Embodiment Construction

[0038] Immediate treatment for patients suffering from stroke is often not possible in clinical situations, and new treatment strategies are urgently needed by physicians.

[0039] Among other things, the invention provides compositions and methods for treating neuropathic injury in a subject. In particular, the present invention provides methods for promoting recovery of function in a subject that has suffered neurological injury, such as from acute ischemic stroke, by administering a composition comprising a selective p38-αMAPK inhibitor. In some embodiments, the present invention provides methods for promoting neurological recovery from ischemic injury by administering a composition comprising a selective p38-[alpha] MAPK inhibitor.

[0040] The following sections describe various aspects of the invention in detail. The use of segments is not meant to limit the invention. Each segment may apply to any aspect of the invention. In this patent application, the use of "or" m...

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Abstract

The present invention provides methods and compositions for promoting recovery of function from neurologic injury, such as ischemic injury caused by acute stroke.

Description

[0001] Cross References to Related Applications [0002] This patent application claims the benefit of US Provisional Application No. 62 / 246,574, filed October 26, 2015, which is hereby incorporated by reference in its entirety. Background technique [0003] Stroke is the leading cause of severe long-term disability and the third leading cause of death in the United States. The total health cost of disability due to stroke is estimated at $53.6 billion per year. Ischemic stroke accounts for more than 88% of all strokes, making it the most common type of cerebrovascular injury. Ischemic conditions in the brain promote neuronal death, resulting in sensorimotor and cognitive deficits. [0004] To date, research and development of therapies for the treatment of stroke have focused on methods for preventing or reducing neuronal cell damage (ie, as "neuroprotectants" for "neuroprotection") within the immediate 24 hours of stroke . However, decades of research have yielded only ...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61K31/5025A61P25/00
CPCA61K31/519A61P25/00A61P43/00A61P9/10A61K9/0053
Inventor J·J·阿拉姆
Owner EIP PHARMA
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