Absorbable high-performance nanofiber woven tendon patch and preparation method thereof

A nanofiber, high-performance technology, applied in the field of artificial tendons and artificial ligaments in sports medicine, can solve the problems of poor mechanical properties of tendon scaffolds, messy fibers, and unsatisfactory conditions

Pending Publication Date: 2021-09-14
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the above-mentioned patents all use nanofiber yarns that are helpful for cell repair and regeneration to prepare tendon scaffolds, the tendon scaffolds obtained by the above-mentioned technical solutions have poor mechanical properties and cannot meet the requirements of actual use, because the above-mentioned patents are specifically preparing nanofibers. Fiber yarns only use a rotating funnel, and the opposite side of the rotating funnel does not use a component that can c...

Method used

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  • Absorbable high-performance nanofiber woven tendon patch and preparation method thereof
  • Absorbable high-performance nanofiber woven tendon patch and preparation method thereof
  • Absorbable high-performance nanofiber woven tendon patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] An absorbable high-performance nanofiber woven tendon patch, the tendon patch is woven from warp yarns and weft yarns, wherein the weft yarn direction constitutes the longitudinal direction of the tendon patch, and the warp direction constitutes the transverse direction of the tendon patch; the warp yarn is biodegradable micron Fiber yarn or biodegradable nanofiber yarn, the weft yarn is biodegradable nanofiber yarn; biodegradable nanofiber yarn is a twisted primary yarn formed by twisting oriented nanofibers obtained by electrospinning technology , and then the pure twisted nanofiber yarn prepared by thermal drawing treatment of the twisted initial yarn, such as figure 1 shown. In this embodiment, the biodegradable nanofiber yarn is a pure twisted nanofiber yarn obtained by electrospinning high polymer poly-L-lactic acid (PLLA), and then the obtained pure twisted nanofiber yarn is used as a weft yarn , with biodegradable PLLA micron fiber yarn as the warp, the appeara...

Embodiment 2

[0051] The same as Example 1 will not be repeated, the difference is that in this example, the biodegradable nanofiber yarn is made of high polymer silk fibroin (SF) and poly-L-lactic acid (PLLA) mixed electrospun Purely twisted nanofiber yarns obtained from silk were then woven from warp and weft yarns to form a strip-like tendon patch. Wherein, the warp and weft yarn density of the tendon patch of the tendon patch is 63 threads / 10cm×150 threads / 10cm.

[0052] When preparing the spinning solution, use an electronic balance to weigh 0.2g of SF and 0.8g of PLLA, then dissolve them in 10mL of hexafluoroisopropanol, and stir overnight on a magnetic stirrer at room temperature to prepare the mass concentration Percentage is 10% SF / PLLA blended spinning solution; Then the SF / PLLA spinning solution that the mass concentration percentage that makes is 10% is loaded in the double reservoir, obtains biodegradable nanofiber yarn; Finally by In the weaving process of textile and weaving...

Embodiment 3

[0054] The similarities with Example 2 will not be repeated, the difference is that in this embodiment, the warp and weft yarn density of the tendon patch of the tendon patch is 138 yarns / 10cm×238 yarns / 10cm.

[0055] When preparing the spinning solution, use an electronic balance to weigh 0.35g of SF and 0.65g of PLLA, then dissolve them in 10mL of hexafluoroisopropanol, and stir overnight on a magnetic stirrer at room temperature to prepare the mass concentration Percentage is 10% SF / PLLA blended spinning solution; Then the SF / PLLA spinning solution that the mass concentration percentage that makes is 10% is loaded in the double reservoir, obtains biodegradable nanofiber yarn; Finally by In the weaving process of textile and weaving technology, the prepared biodegradable nanofiber yarn is used as the weft yarn, and the biodegradable PLLA micron fiber yarn is used as the warp yarn. Interweaving according to the plain weave on the loom to prepare absorbable and high-performanc...

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Abstract

The invention relates to an absorbable high-performance nanofiber woven tendon patch. The absorbable high-performance nanofiber woven tendon patch is formed by weaving warp yarns and weft yarns, the weft yarns form the longitudinal direction of the tendon patch, and the warp yarns form the transverse direction of the tendon patch; the warp yarns are biodegradable nanofiber yarns or biodegradable micron fiber yarns, and the weft yarns are biodegradable nanofiber yarns; and the biodegradable nanofiber yarns are pure twisted nanofiber yarns which are prepared by twisting initial twisted yarns formed by twisting oriented nanofibers obtained by adopting an electrostatic spinning technology and then carrying out hot drafting treatment on the initial twisted yarns. The invention also provides a preparation method. The tendon patch prepared by the preparation method provided by the invention can effectively simulate a nanofiber multilevel structure of a natural tendon extracellular matrix, has an ultrahigh specific surface area, can provide more sites for adhesion and growth of cells, has ultrahigh mechanical properties, can provide a reliable mechanical support for new tissue regeneration, and is beneficial to regeneration and reconstruction of injured tendon tissues.

Description

technical field [0001] The invention relates to the technical field of sports medicine artificial tendons and artificial ligaments, in particular to an absorbable high-performance nanofiber woven tendon patch and a preparation method thereof. Background technique [0002] With the progress of human civilization and people's pursuit of health, people's outdoor sports have increased significantly. Due to the continuous occurrence of accidents and the increasingly obvious trend of aging society, sports injuries are also increasing. Among them, more than 50% of tendon and ligament injuries are caused by trauma and degenerative diseases, and tendon injuries are very common in the field of clinical medicine, especially in the field of sports medicine. According to statistics, there are more than 30 million tendon injuries in the world every year, which lead to more than 156 billion US dollars in medical expenses. Due to the low cellularity, low degree of vascularization, and ver...

Claims

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Application Information

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IPC IPC(8): D03D25/00D03D15/33D03D15/50D03D13/00D03D9/00D03D15/292D03D15/283A61L27/18A61L27/20A61L27/22A61L27/24A61L27/58
CPCD03D25/005D03D15/33D03D15/50D03D13/008D03D9/00D03D15/292D03D15/283A61L27/222A61L27/24A61L27/227A61L27/20A61L27/18A61L27/58D10B2331/041D10B2211/22D10B2401/12D10B2401/063A61L2430/10
Inventor 吴韶华刘蛟陈韶娟马建伟
Owner QINGDAO UNIV
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