Absorbable high-performance nanofiber woven tendon patch and preparation method thereof

Abstract

The invention relates to an absorbable high-performance nanofiber woven tendon patch. The absorbable high-performance nanofiber woven tendon patch is formed by weaving warp yarns and weft yarns, the weft yarns form the longitudinal direction of the tendon patch, and the warp yarns form the transverse direction of the tendon patch; the warp yarns are biodegradable nanofiber yarns or biodegradable micron fiber yarns, and the weft yarns are biodegradable nanofiber yarns; and the biodegradable nanofiber yarns are pure twisted nanofiber yarns which are prepared by twisting initial twisted yarns formed by twisting oriented nanofibers obtained by adopting an electrostatic spinning technology and then carrying out hot drafting treatment on the initial twisted yarns. The invention also provides a preparation method. The tendon patch prepared by the preparation method provided by the invention can effectively simulate a nanofiber multilevel structure of a natural tendon extracellular matrix, has an ultrahigh specific surface area, can provide more sites for adhesion and growth of cells, has ultrahigh mechanical properties, can provide a reliable mechanical support for new tissue regeneration, and is beneficial to regeneration and reconstruction of injured tendon tissues.

Description

technical field [0001] The invention relates to the technical field of sports medicine artificial tendons and artificial ligaments, in particular to an absorbable high-performance nanofiber woven tendon patch and a preparation method thereof. Background technique [0002] With the progress of human civilization and people's pursuit of health, people's outdoor sports have increased significantly. Due to the continuous occurrence of accidents and the increasingly obvious trend of aging society, sports injuries are also increasing. Among them, more than 50% of tendon and ligament injuries are caused by trauma and degenerative diseases, and tendon injuries are very common in the field of clinical medicine, especially in the field of sports medicine. According to statistics, there are more than 30 million tendon injuries in the world every year, which lead to more than 156 billion US dollars in medical expenses. Due to the low cellularity, low degree of vascularization, and ver...

AI Technical Summary

Problems solved by technology

[0007] Although the above-mentioned patents all use nanofiber yarns that are helpful for cell repair and regeneration to prepare tendon scaffolds, the tendon scaffolds obtained by the above-mentioned technical solutions have poor mechanical properties and cannot meet the requirements of actual use, because the above-mentioned patents are specifically preparing nanofibers. Fiber yarns only use a rotating funnel, and the opposite side of the rotating funnel does not use a component that can combine with it to make the electric field form a split electric field. That is to say, the electric field does not induce the orientation of the formed nanofibers, resulting in the obtained Fibers appear messy

However, the disorder of the fibers makes it impossible to stretch effectively, which makes the mechanical properties of the prepared yarn poor, which ultimately affects the strength of the scaffold, which is not conducive to the repair of tendon injuries and the recovery of normal functions.

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