Parkinson's disease microneedle patch based on L-DOPA space-time controllable administration strategy and preparation method thereof

A technology of Parkinson's disease and microneedle sticking, which is applied in the direction of microneedle, medical formula, drug equipment, etc., to achieve the effect of improving treatment effect, improving absorption efficiency and easy control

Pending Publication Date: 2021-12-24
TANGYI HLDG(SHENZHEN) LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, there is no literature in the prior art that combines light-controlled drug-loaded treatment of Parkinson's disease with microneedle technology to achieve a microne

Method used

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  • Parkinson's disease microneedle patch based on L-DOPA space-time controllable administration strategy and preparation method thereof
  • Parkinson's disease microneedle patch based on L-DOPA space-time controllable administration strategy and preparation method thereof
  • Parkinson's disease microneedle patch based on L-DOPA space-time controllable administration strategy and preparation method thereof

Examples

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preparation example Construction

[0085] In the method for preparing the light-controlled drug-loaded microneedle patch product 100 of the present invention as described above, the technical features and their preferred aspects described above in the light-controlled drug-loaded microneedle patch product 100 of the present invention Range still applies here.

[0086] In the third aspect of the present invention, the present invention relates to the light-controlled drug-loaded microneedle patch product 100 as described above in the first aspect or prepared according to the method for preparing the light-controlled drug-loaded microneedle patch product 100 in the above second aspect The light-controlled drug-loaded microneedle patch product 100 is used to alleviate and / or treat Parkinson's disease in animals.

[0087] In the fourth aspect of the present invention, the present invention relates to the light-controlled drug-loaded microneedle patch product 100 as described above in the first aspect or prepared ac...

preparation Embodiment 1 to 6

[0105] Preparation Examples 1 to 6: Preparations 1 to 6 of the light-controlled drug-loaded microneedle patch products of the present invention were prepared according to the following general preparation process. The general preparation method comprises the following steps: (1) preparing an up-conversion microrod drug delivery system; (2) adding the following steps to the solution containing the up-conversion microrod delivery system obtained in step (1) as shown in Table 1. The amount of base material (methacrylate gelatin or HA) to form a mixed solution: (3) provide the microneedle mold; (4) place the mixed solution obtained by step (2) into the molding of the microneedle mold (5) make the mixed solution comprising the matrix material and the up-converting microrod drug delivery system solution in the forming hole under the conditions shown in Table 1 Carry out cross-linking, thereby form described microneedle in described molding hole; (6) on the bottom end surface of desc...

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Abstract

The invention relates to a Parkinson's disease microneedle patch based on an L-DOPA space-time controllable administration strategy. The Parkinson's disease microneedle patch comprises a back lining and a drug-loaded microneedle array attached to one side surface of the back lining, wherein the drug-loaded microneedle array comprises a plurality of microneedles, each microneedle comprises a large number of mesoporous-silica-coated up-conversion microrods, common drugs for treating Parkinson's disease are loaded into mesopores, and an azo compound is used as a pore sealing agent. After the microneedle patch is applied to skin and irradiated with 1.56W/cm<2> near-infrared light (980nm), both ultraviolet light and visible light are emitted. Photons can be absorbed by photoresponsive azo molecules in mesoporous silica on surfaces of UCMRs, then, reversible photoisomerization occurs immediately, continuous rotational-reversal motion of azo is caused, and thus, controlled release of levodopa from the microneedles is triggered. Under the same administration condition, the microneedle patch has a higher blood drug concentration and a higher brain drug concentration and meanwhile also has sensitive light-controlled drug release characteristic, and a drug concentration can be controlled within a proper range.

Description

technical field [0001] The invention relates to the field of microneedle patches, in particular to a microneedle patch for Parkinson's disease based on an L-DOPA spatiotemporal controllable drug delivery strategy and a preparation method. The microneedle patch product contains a microneedle patch and can treat Parkinson's disease by controlling the release dose of L-DOPA from the microneedle patch. The present invention also relates to a method for preparing the light-controlled drug-loaded microneedle patch product and the use of the light-controlled drug-loaded microneedle patch product for treating Parkinson's disease. Background technique [0002] Parkinson's disease (PD) is a common degenerative disease of the central nervous system in middle-aged and elderly people. Common symptoms are tremor, stiffness, and slowness of movement. Currently, oral L-DOPA is one of the most commonly used drugs for the treatment of Parkinson's disease. While this approach is effective i...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/70A61K31/198A61K47/04A61K47/32A61K47/34A61K47/36A61K47/38A61K47/42A61M37/00A61P25/16
CPCA61M37/0015A61K9/0021A61K9/703A61K41/0042A61K31/198A61K47/34A61K47/42A61K47/38A61K47/36A61K47/32A61K47/02A61P25/16A61M2037/0046A61M2037/0053A61K2300/00
Inventor 郑斌曹毓琳李博文孙维程世翔
Owner TANGYI HLDG(SHENZHEN) LTD
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