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Composition with effects of protecting joints and increasing bone mineral density and preparation method of composition

A technology to increase bone density and protect joints, applied to medical preparations containing active ingredients, drug combinations, applications, etc., can solve problems such as increased bone fragility, prone to bone pain, fractures, and unable to fundamentally solve bone health

Pending Publication Date: 2016-03-02
SHENZHEN TAITAI PHARMA IND +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Currently popular sayings include calcium supplementation to prevent and treat osteoporosis, but clinical studies have shown that most osteoporosis patients are not caused by calcium deficiency, and simple supplementation of calcium and other inorganic substances not only cannot guarantee absorption, but will also cause osteoporosis. The fragility of the bone increases, and it is more prone to bone pain, fractures and other malignant consequences, so it cannot fundamentally solve the purpose of bone health

Method used

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  • Composition with effects of protecting joints and increasing bone mineral density and preparation method of composition
  • Composition with effects of protecting joints and increasing bone mineral density and preparation method of composition
  • Composition with effects of protecting joints and increasing bone mineral density and preparation method of composition

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Comparison scheme
Effect test

Embodiment 1

[0071] Embodiment 1: preparation of composition tablet of the present invention

[0072] 1. Raw material composition:

[0073] Calcium citrate malate 330g, glucosamine sulfate potassium salt 220g, chondroitin sulfate 160g, bone collagen peptide powder 100g, casein phosphopeptide 30g.

[0074] 2. The auxiliary materials are composed of:

[0075] Lactose 50g, copovidone 50g, microcrystalline cellulose 40g, silicon dioxide 5g, magnesium stearate 5g.

[0076] 3. Preparation method:

[0077](1) Measure the moisture of each raw and auxiliary material, and control the moisture to ≤5.0%;

[0078] (2) Pass calcium citrate malate, collagen peptide powder, casein phosphopeptide, lactose, copovidone, and microcrystalline cellulose through a 60-mesh sieve; chondroitin sulfate and magnesium stearate pass through an 80-mesh sieve, press The formula weighs each raw and auxiliary material;

[0079] (3) Mix glucosamine sulfate potassium salt and silicon dioxide for 5 minutes, pass through...

Embodiment 2

[0082] Embodiment 2: preparation of composition tablet of the present invention

[0083] 1. Raw material composition:

[0084] Calcium citrate malate 400g, glucosamine sulfate potassium salt 150g, chondroitin sulfate 200g, bone collagen peptide powder 50g, casein phosphopeptide 40g.

[0085] 2. Composition of auxiliary materials:

[0086] Lactose 70g, copovidone 50g, microcrystalline cellulose 30g, silicon dioxide 5g, magnesium stearate 5g.

[0087] 3. Preparation method:

[0088] (1) Measure the moisture content of each raw and auxiliary material, and control the moisture content to ≤5.0%;

[0089] (2) Pass each raw and auxiliary material through a 60-mesh sieve, and weigh each raw and auxiliary material according to the formula;

[0090] (3) Mix glucosamine sulfate potassium salt and silicon dioxide for 30 minutes, and then mix with the above-mentioned other materials that have been sieved with an automatic lifting hopper mixer for 45 minutes, then put the materials in...

Embodiment 3

[0092] Embodiment 3: preparation of composition tablet of the present invention

[0093] 1. Raw material composition:

[0094] Calcium citrate malate 250g, glucosamine sulfate potassium salt 300g, chondroitin sulfate 100g, bone collagen peptide powder 150g, casein phosphopeptide 40g.

[0095] 2. Composition of auxiliary materials:

[0096] Lactose 30g, copovidone 50g, microcrystalline cellulose 55g, silicon dioxide 5g, magnesium stearate 10g.

[0097] 3. Preparation method:

[0098] (1) Measure the moisture content of each raw and auxiliary material, and control the moisture content to ≤5.0%;

[0099] (2) Pass each raw and auxiliary material through an 80-mesh sieve, and weigh each raw and auxiliary material according to the formula;

[0100] (3) Mix glucosamine sulfate potassium salt and silicon dioxide for 10 minutes, then mix with the above-mentioned other materials that have been sieved with an automatic lifting hopper mixer for 75 minutes, then put the materials int...

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Abstract

The invention provides a composition with effects of protecting joints and increasing bone mineral density. The composition is prepared from the following components in parts by weight: 250-400 parts of calcium citrate malate, 150-300 parts of N-Sulfo-glucosamine potassium salt, 100-200 parts of chondroitin sulfate, 50-150 parts of bone collagen peptide powder, and 10-50 parts of casein phosphopeptides. According to the composition provided by the invention, the active ingredients achieve the synergistic effect, the bioavailability is high, and the composition can be used for increasing the bone mineral density and restoring the bone functions. Through a preparation method provided by the invention, the composition can be prepared into a compound preparation, the curative effects are definite, the quality is controllable, no toxic or side effect exists, and the composition is suitable for large-scale popularization and application.

Description

technical field [0001] The present invention relates to a composition, in particular to a composition with the functions of protecting joints and increasing bone density. Background technique [0002] Osteoporosis (OP) is a systemic skeletal disease characterized by decreased bone mass, damaged bone microarchitecture, increased bone fragility, and susceptibility to fracture. According to the data of the World Health Organization, the incidence rate of osteoporosis is 21% at the age of 50-60, 58% at the age of 60-70, and almost 100% at the age of 70-80, especially in postmenopausal women and elderly men. The incidence rate is higher, and there is a younger trend. In particular, the eating habits of Chinese residents can easily lead to insufficient calcium intake, which in turn leads to an increasingly serious incidence of osteoporosis. Therefore, the prevention and treatment of osteoporosis is imperative. [0003] At present, the etiology and pathogenesis of primary osteop...

Claims

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Application Information

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IPC IPC(8): A61K38/39A23L33/00A23L33/125A23L2/38A23L2/39A61P19/10A61P19/02A61K31/737A61K31/7008A61K38/17A61K31/194A61K31/12
CPCA61K38/1709A61K38/39A23L2/38A23L2/39A61K9/1652A61K9/2054A61K9/28A61K31/12A61K31/194A61K31/7008A61K31/737A23V2002/00A61K2300/00A23V2200/306A23V2200/30A23V2250/1628A23V2250/2112A23V2250/51A23V2250/51084A23V2250/55A23V2250/612A23V2250/5114
Inventor 常弘杰余孝云李志明陆宝宝
Owner SHENZHEN TAITAI PHARMA IND
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