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Bioactivity glass porous bone repair material and preparation method thereof

A bioactive glass and bone prosthetic technology, applied in prosthetics, tissue regeneration, medical science, etc., can solve the problems of not being widely used in clinical practice, and achieve the advantages of cell adhesion and proliferation, easy access to raw materials, and easy process parameters The effect of control

Inactive Publication Date: 2018-06-12
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To overcome the problem that the current clinical products of bioactive glass are mostly in the form of granules and powders, and the clinical use is not wide enough

Method used

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  • Bioactivity glass porous bone repair material and preparation method thereof
  • Bioactivity glass porous bone repair material and preparation method thereof
  • Bioactivity glass porous bone repair material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Preparation steps of bioactive glass powder

[0039] Add 12mol / l hydrochloric acid (3ml) into deionized water (125ml) to form a mixed solution. After stirring at room temperature for 10 minutes, add 80ml of tetraethyl orthosilicate, 8ml of triethyl phosphate, and 46g of calcium nitrate tetrahydrate in sequence, and the time interval between each addition is 30 minutes; after the addition of materials, continue to stir for 5 hours and then stop stirring , the obtained solution was aged at room temperature for 3 days to obtain a gel, and then the gel was dried at 60° C. for 1 day and at 120° C. for 1 day. Sinter in an electric furnace at 650°C for 3 hours to obtain 58S bioactive glass powder, which is ball milled and sieved, and the bioactive glass powder with a particle size of not more than 90 μm is taken for use.

[0040] (2) Preparation steps of bioactive glass bone prosthesis

[0041]Using mannitol, 58S bioactive glass powder, and PVA as raw materials, the mass...

Embodiment 2

[0045] (1) Preparation steps of bioactive glass powder

[0046] Add 12mol / l hydrochloric acid (3ml) into deionized water (125ml) to form a mixed solution. After stirring at room temperature for 10 minutes, add 80ml of tetraethyl orthosilicate, 8ml of triethyl phosphate, and 46g of calcium nitrate tetrahydrate in sequence, and the time interval between each addition is 30 minutes; after the addition of materials, continue to stir for 5 hours and then stop stirring , the obtained solution was aged at room temperature for 3 days to obtain a gel, and then the gel was dried at 60° C. for 1 day and at 120° C. for 1 day. Sinter in an electric furnace at 650°C for 3 hours to obtain 58S bioactive glass powder, which is ball milled and sieved, and the bioactive glass powder with a particle size of not more than 90 μm is taken for use.

[0047] (2) Preparation steps of bioactive glass bone prosthesis

[0048] Ammonium bicarbonate, starch, 58S bioactive glass powder, and PVA are used as...

Embodiment 3

[0052] (1) Preparation steps of bioactive glass powder

[0053] Add 12mol / l hydrochloric acid (3ml) into deionized water (125ml) to form a mixed solution. After stirring at room temperature for 10 minutes, add 80ml of tetraethyl orthosilicate, 8ml of triethyl phosphate, and 46g of calcium nitrate tetrahydrate in sequence, and the time interval between each addition is 30 minutes; after the addition of materials, continue to stir for 5 hours and then stop stirring , the obtained solution was aged at room temperature for 3 days to obtain a gel, and then the gel was dried at 60° C. for 1 day and at 120° C. for 1 day. Sinter in an electric furnace at 650°C for 3 hours to obtain 58S bioactive glass powder, which is ball milled and sieved, and the bioactive glass powder with a particle size of not more than 90 μm is taken for use.

[0054] (2) Preparation steps of bioactive glass bone prosthesis

[0055] Using ammonium bicarbonate, starch, mannitol, 58S bioactive glass powder, and...

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Abstract

The invention discloses a bioactivity glass porous bone repair material and a preparation method thereof. The method includes: using a sol-gel method to prepare bioactivity glass powder, evenly mixingthe bioactivity glass powder, a binder and a pore-forming agent, performing compression molding, performing isostatic cool pressing, and performing thermal treatment sintering to remove the pore-forming agent so as to obtain the 58S bioactivity glass porous bone repair material. The bioactivity glass porous bone repair material and the preparation method have the advantages that the pore diameterof the prepared bone repair material is about 50-300 micrometers, the porosity of the prepared bone material can be controlled to be 40-70%, and the prepared bone repair material which has the mechanical performance similar to cancellous bones is good in pore diameter uniformity, good in surface smoothness, controllable in degradation rate and applicable to bone defect repair and bone tissue regeneration; meanwhile, the preparation method is simple in process, easy in raw material obtaining, low in cost and easy to achieve industrialization.

Description

technical field [0001] The invention relates to the field of preparation of bone defect tissue repair materials, in particular to a bioactive glass porous bone repair material and a preparation method thereof. Background technique [0002] In recent years, the number of patients with bone defects in my country has been increasing year by year. Finding materials for repairing bone defect tissue is a key problem that needs to be solved urgently in the field of orthopedic medical research. Although autologous bone grafting is still the "gold" standard for clinical bone defect treatment, it is not suitable for large bone defects due to limited resources and possible secondary trauma. Recently, bone tissue engineering technology has changed the mode of traumatic repair in the past. Bone prosthesis, as the core issue in bone tissue engineering, must not only meet the necessary biological properties, but also have porosity and certain strength. From the perspective of products, it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/12A61L27/50A61L27/56
CPCA61L27/10A61L27/12A61L27/50A61L27/56A61L2430/02
Inventor 陈晓峰廖天舜陈建辉欧阳鹿罗曼
Owner SOUTH CHINA UNIV OF TECH
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