Composition for regeneration of cartilage

a cartilage and collagen technology, applied in the direction of drugs, peptide/protein ingredients, prosthesis, etc., can solve the problems of lack of vascular and neural networks, lack of cartilage defect lesion repair ability, etc., to reduce the burden on patients
US20140213524A1Inactive Publication Date: 2014-07-31MOCHIDA PHARM CO LTD +1
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
MOCHIDA PHARM CO LTD
Publication Date
2014-07-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

A novel composition for regenerating a cartilage has been demanded, which can achieve a good effect of regenerating a hyaline cartilage that is a nearly normal cartilage without requiring the use of any transplanted cell. The present invention provides a composition for regenerating a cartilage, wherein (a) a monovalent metal salt of low endotoxin alginic acid and (b) SDF-1 are used in combination.
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Description

TECHNICAL FIELD

[0001] The present invention relates to a composition for cartilage regeneration and the like.BACKGROUND ART

[0002] Articular cartilage is hyaline cartridge that is composed of a small number of cells, collagenous extracellular matrix, abundant proteoglycans and water. Since vascular and neural networks are present in the bone and the bone has self-repairing ability, even when a bone is fractured, the fractured site is often adequately repaired. Articular cartilage, however, lacks vascular and neural networks. Accordingly, it has very little self-repairing ability and thus a cartilage defect lesion is not adequately repaired particularly when a large defect lesion is formed in the cartilage. Even when the lesion is repaired, the lesion is remodeled with fibrous cartilage that has different mechanical property from that of hyaline cartilage. Therefore, a cartilage defect lesion leads to pain in the joint and loss of joint function, which often result in development of ost...

Claims

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