Growth factor nanotube slow-release system used for osseointegration and preparation method and application thereof

A growth factor and nanotube technology, used in medical science, surgery, etc., can solve the problems that the biological activity of growth factors cannot be maintained for a long time, the research has not been reported in the literature, and there is explosive release. The amount of drug and the effect of promoting osseointegration
CN104436313AInactive Publication Date: 2015-03-25SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Publication Date
2015-03-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a growth factor nanotube slow-release system used for osseointegration and a preparation method and application thereof, the nanotube slow-release system includes a titanium alloy implant, a titanium dioxide nanotube coating is prepared on the titanium alloy implant surface by the method of anodic oxidation, and the titanium alloy implant is loaded with a growth factor. The growth factor nanotube slow-release system has the advantages that: (1) the growth factor nanotube slow-release system can improve the nanotube drug loading amount by a simple and effective method of vacuum aspiration; (2) the invention also provides a rhPDGF- BB nanotube slow-release system which can significantly promote the osseointegration in bone osteoporosis state, rhPDGF-BB is approved by the FDA to be used in clinical osteanagenesis therapies, and clinical application of the nanotube slow-release system may be provided; and (3) including nanotube preparation, therowth factor nanotube slow-release system is in no need of special, complex and expensive equipment, simple in operation process, and conducive to the promotion and use.
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Description

Technical field

[0001] The invention relates to the field of bone tissue regeneration and osseointegration, in particular to a growth factor nanotube slow-release system applied to osseointegration, and a preparation method and application thereof. Background technique

[0002] Osteoporosis is due to defects in the coupling of bone resorption and bone formation in the process of bone metabolism, resulting in decreased bone density and bone destruction, which seriously affects the speed and quality of bone repair and osseointegration; due to the lack of effective means to solve this problem Problem, osteoporosis is still listed as a contraindication for dental implant surgery. With the continuous development and maturity of nanotechnology, a variety of nano-modified coatings have been used to improve the osteoinductive properties on the surface of titanium implants. Among them, the nanotube coating prepared by anodizing technology not only has obvious regulation of stem cell osteo...

Claims

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