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Three-dimensional matrices of structured porous monetite for tissue engineering and osseous regeneration, and method for the preparation thereof

A monetite, structured technology, applied in the fields of tissue engineering and bone regeneration, can solve the problems of not being effective and not proposing monetite materials.

Active Publication Date: 2011-06-08
HISTOCELL SL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in its specific embodiments, the invention proposes brushite materials, not monetite materials, and wherein said present macroporous structure is not valid for the purposes of the present invention

Method used

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  • Three-dimensional matrices of structured porous monetite for tissue engineering and osseous regeneration, and method for the preparation thereof
  • Three-dimensional matrices of structured porous monetite for tissue engineering and osseous regeneration, and method for the preparation thereof
  • Three-dimensional matrices of structured porous monetite for tissue engineering and osseous regeneration, and method for the preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0200] Embodiment 1: the synthetic method of matrix of the present invention

[0201] To synthesize the matrix of the invention, the solid phase was mixed with double distilled water (liquid phase).

[0202] The solid phase includes, but is not limited to, acidic calcium phosphate, basic calcium phosphate, pore inducers such as calcium carbonate, and retarders such as sodium pyrophosphate.

[0203] 1.1 Preparation of solid phase

[0204] The solid phase of the calcium paste consists of alkaline calcium phosphate and acidic calcium phosphate. The basic calcium phosphate is β-tricalcium phosphate (β-TCP), and the acidic calcium phosphate is monocalcium phosphate. These two components were mixed by hand in a mortar and mortar at a molar ratio of 1.785 for 10 minutes. Calcium carbonate is added at a concentration between 1-20% by weight, preferably between 3-10%. 0.54% by weight of sodium pyrophosphate was used as a retarder for the coagulation reaction.

[0205] Specific...

Embodiment 2

[0228] Example 2: Specific production process of specific monetite granules with structured pores

[0229] By way of example and for the purpose of obtaining a viscous slurry with the most preferred characteristics, a powder component formed from 0.8 g anhydrous monocalcium phosphate, 1.4 g β-tricalcium phosphate, 12 mg sodium pyrophosphate and 110 mg calcium carbonate was mixed with 0.77 ml The water is mixed for 30 seconds. One minute after starting to cure, the mold described below was applied to the grout for 30 seconds.

[0230] 2.1 Using a single mold in the described process to obtain a cylindrical matrix with structured porosity

[0231] For the implementation of this example, a silicone mold with the following dimensions and number of punches was used:

[0232] a) Diameter 1cm, height 5mm or 3mm, 64 punching holes

[0233] b) Diameter 0.8cm, height 5mm or 3mm, 39 punching holes

[0234] c) Diameter 0.7cm, height 5mm or 3mm, 28 punching holes

[0235] d) Diame...

Embodiment 3

[0270] Example 3: Between monetite with structured porosity and matrix of amorphous monetite comparative study between

[0271] 3.1 Microscopic research

[0272] A comparison test of the microstructure of the amorphous matrix with that of the matrix with structured porosity was then carried out. To carry out this test, scanning electron microscopy is used by procedures known to those skilled in the art.

[0273] Microstructure of Amorphous Porous Monetite Matrix

[0274] Biomaterials arranged in the form of an amorphous matrix ( Figure 6 a, b) Obtaining uncontrolled porosity. In other words, they show an irregular distribution of macropores, which is produced during the process of obtaining viscous pulp as described in Examples 1.1 to 1.6. The macropores of the amorphous matrix are cavities in the biomaterial and do not connect internal structures ( Figure 7 ).

[0275] With regard to the number and distribution of macropores, their absence is observed. The pr...

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Abstract

The present invention is in the field of tissue engineering and, specifically, that of osseous regeneration. The invention relates to a porous three-dimensional matrix of biocompatible monetite, of predefined structured porosity and reabsorbable, and method of synthesis capable of producing said material and applications thereof. These matrices constitute a perfect base for cell colonisation and proliferation permitting application thereof in tissue engineering and osseous regeneration by virtue of their advantageous properties of biocompatibility, reabsorption, osteoinduction, revascularisation, etc.

Description

technical field [0001] The present invention relates to the field of tissue engineering, in particular to the field of bone regeneration. The present invention relates to porous three-dimensional matrices of monetite which are biocompatible, have structured pores, are predefined, and are resorbable, and to synthetic methods enabling the production of said materials and their applications . These matrices are perfect matrices for cell colonization and proliferation, enabling their application in tissue engineering and bone regeneration due to their favorable properties such as biocompatibility, resorbability, osteoinductivity, revascularization, etc. Background technique [0002] Loss of bone mass and quality is a serious health problem, more common in older patients. [0003] The success of using three-dimensional materials - initially colonized by progenitor cells in vitro - in the regeneration of bone defects depends largely on the properties and structure of the materia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32A61L27/12A61F2/02A61F2/28
CPCA61F2/28A61L27/12A61L27/3847C01B25/32A61L27/3804A61L27/58A61L27/56A61L27/38A61L2430/02A61P19/00Y10T428/24744A61L27/42A61L2430/00
Inventor 胡里奥·方特·佩雷斯玛丽亚·毕格纳·卡斯特罗·费奥德尔·奥尔莫·巴斯特里夏玛丽亚·德洛丽丝·加西亚·瓦兹奎兹豪尔赫·卢比奥·雷塔马恩里克·洛佩斯·卡巴科斯卡门·鲁埃达·罗德里格斯法莱·塔米米·马力诺穆罕默德·哈姆丹·阿利·阿尔卡莱斯特
Owner HISTOCELL SL
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