Porous biological activity glass bone restoration material, preparation method and application thereof

A technology for bioactive glass and bone repair, applied in tissue regeneration, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the lack of theoretical basis for the application of porous bioactive glass bone repair materials, and the biocompatibility of glass bone repair materials Poor sex, low efficiency of bone repair, etc., to achieve good osteoinductive activity, no immune rejection, and shorten the repair cycle

Inactive Publication Date: 2019-01-22
HUBEI SHUANGXING PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing prepared glass bone repair materials have poor biocompatibility;
[0005] At the same time, the efficiency of bone repair is relatively low, and it takes a long time to be densely integrated with bone
[0006] In the prior art, there is no theoretical basis for the application of porous bioactive glass bone repair materials

Method used

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  • Porous biological activity glass bone restoration material, preparation method and application thereof
  • Porous biological activity glass bone restoration material, preparation method and application thereof
  • Porous biological activity glass bone restoration material, preparation method and application thereof

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Embodiment Construction

[0043] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0044] The application principle of the present invention will be further described below in conjunction with the accompanying drawings.

[0045] The porous bioactive glass bone repair material components provided by the embodiments of the present invention include:

[0046] 12 parts of calcium chloride, 8 parts of barium chloride, 12 parts of absolute ethanol, 6 parts of phosphorus pentoxide, 10 parts of ethylenediaminetetraacetic acid, 30 parts of tetrabutyl titanate lecithin, 25 parts of animal bone morphogenetic protein , 10 parts of chitosan, 5 parts of hydroxyapatite, 10 parts of gelatin, 13 parts of ammonia water, a...

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Abstract

The invention belongs to the technical field of glass bone restoration, and discloses a porous biological activity glass bone restoration material, a preparation method and application thereof. Aftera prepared porous biological activity glass bone restoration material being implanted into an organism, the biocompatibility is good; the prepared bone restoration material is composed of natural macromolecular materials and inorganic materials being bone-like components, the surface of the prepared bone restoration material is capable of forming a good interface relation with cells, any parts ofany bone defect can be implanted in a orthopedic surgery, application parts are not limited, good biocompatibility, no cytotoxicity and no immune rejection are achieved. According to the prepared bonerestoration material adopted by the preparation method, good degradation performance is achieved, materials are gradually degraded with growth of new bone, and thus no occupation and no interfere tobone reconstruction are achieved; and the restoration cycle is shortened.

Description

technical field [0001] The invention belongs to the technical field of glass bone repair, and in particular relates to a porous bioactive glass bone repair material and its preparation method and application. Background technique [0002] Vitreous bone is called congenital osteogenesis imperfecta. It is a collagen fiber lesion caused by congenital genetic defects. During normal exercise, most of the muscles in the whole body will atrophy. The clinical features are osteoporosis and fragility, prone to fractures. However, the currently prepared glass bone repair materials have poor biocompatibility; at the same time, the efficiency of bone repair is relatively low, and it takes a long time to be densely combined with the bone. [0003] In summary, the problems in the prior art are: [0004] The existing prepared glass bone repair materials have poor biocompatibility; [0005] At the same time, the efficiency of bone repair is relatively low, and it takes a long time to com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/54A61L27/56A61L27/58A61K38/18
CPCA61K38/1875A61L27/46A61L27/54A61L27/56A61L27/58A61L2430/02
Inventor 廖先传廖书辉
Owner HUBEI SHUANGXING PHARMA CO LTD
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