Polymer nano hydrogel and preparation method thereof

A nano-hydrogel and polymer technology, applied in the field of nano-hydrogel, can solve problems such as application limitations, achieve good biocompatibility, rapid release, and improve the effect of curative effect

Active Publication Date: 2011-06-15
CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For example, the Chinese patent document with application number 200610148155.5 discloses a temperature-sensitive chemically cross-linked hydrogel, which consists of polyethylene glycol as a hydrophilic block and degradable polyester as a hydrophobic block. Copolymer as the main body, connected with cross-linkable groups to form polymer chemically cross-linked hydrogel, the hydrogel is only sensitive to temperature, not to reducing agents, and its application as a drug carrier in tumor cells is limited

Method used

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  • Polymer nano hydrogel and preparation method thereof
  • Polymer nano hydrogel and preparation method thereof
  • Polymer nano hydrogel and preparation method thereof

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preparation example Construction

[0040] The present invention also provides a method for preparing the polymer nanohydrogel described in the above technical scheme, comprising the following steps:

[0041] Dissolve the amino-terminated hydrophilic polymer, γ-benzyl-L-glutamate-N-endocarboxylic anhydride, and γ-2-chloroethyl-L-glutamate-N-endocarboxylic anhydride in In the water solvent, the stirring reaction obtains the first intermediate product, the γ-benzyl-L-glutamic acid ester-N-internal carboxylic acid anhydride and the γ-2-chloroethyl-L-glutamic acid ester-N- The ratio of the total number of moles of internal carboxylic acid anhydride to the number of moles of the amino-terminated hydrophilic polymer is 10 to 1000:1, and the γ-benzyl-L-glutamic acid ester-N-internal carboxylic acid anhydride and the The molar ratio of γ-2-chloroethyl-L-glutamate-N-internal carboxylic acid anhydride is 1:0.1~10, and the amino-terminated hydrophilic polymer has the structure of formula (III) or formula (IV) :

[0042] ...

Embodiment 1～5

[0074] Preparation of Example 1-5 terminal aminated polyethylene glycol monomethyl ether

[0075] Prepare end-aminated polyethylene glycol monomethyl ether according to the following method and the amount of raw materials shown in Table 1: After 10 g of polyethylene glycol monomethyl ether and 100 mL of toluene are azeotroped to remove water, dissolve in 100 mL of anhydrous dichloromethane After cooling to 0°C, add triethylamine, dropwise add methanesulfonyl chloride, react for 2h, return to 25°C and continue to stir for 24h, filter after the reaction, settle the filtrate with ether, filter, wash, 25°C Vacuum drying for 24 hours to obtain polyethylene glycol monomethyl ether methanesulfonate;

[0076] Mix 5g of polyethylene glycol monomethyl ether methanesulfonate with 5g of ammonium chloride, dissolve in 250mL of ammonia water, and react at 25°C for 72h. After the reaction, extract the reaction product with dichloromethane, and use a mass fraction of 4% Wash with an aqueous ...

Embodiment 6～10

[0082] The preparation of embodiment 6~10 terminal aminated polyethylene glycols

[0083] Prepare aminated polyethylene glycol according to the following method and the amount of raw materials shown in Table 3: After azeotroping 5 g of polyethylene glycol with 100 mL of toluene to remove water, dissolve it in 100 mL of anhydrous dichloromethane, and cool to 0 °C Finally, add triethylamine, dropwise add methanesulfonyl chloride, react for 2h, return to 25°C and continue to stir for 24h, filter after the reaction, settle the filtrate with ether, filter, wash, and vacuum dry at 25°C for 24h to obtain methyl Polyethylene glycol sulfonate;

[0084] Mix 5g of polyethylene glycol methanesulfonate with 5g of ammonium chloride, dissolve in 250mL of ammonia water, and react at 25°C for 72h. After the reaction, extract the reaction product with dichloromethane, and use chlorinated Wash with sodium aqueous solution, and then dry with anhydrous sodium sulfate. After fully drying, filter o...

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Abstract

The invention provides a polymer nano hydrogel. A polymer matrix of the polymer nano hydrogel comprises a block copolymer with the structure shown in a formula (I) or a formula (II) in the specifications, and the block copolymer is subjected to internal crosslinking through Se-Se bond molecules. The invention further provides a preparation method of the polymer nano hydrogel. In the polymer nano hydrogel provided in the invention, the polymer matrix comprises a poly(L-glutamic acid) chain block containing carboxyl, the carboxyl is sensitive to a pH value and ion strength in a water solution, and the Se-Se bond is sensitive to both reductant and oxidant: in an oxidant environment, the Se-Se bond breaks to generate selenic acid and realize decrosslinking, and in an reductant environment, the Se-Se bond is reduced into selenol to realize decrosslinking. Therefore, the polymer nano hydrogel provided in the invention is simultaneously sensitive to the pH value, the ion strength, the oxidant and the reductant, and can realize quick drug release in target cells so as to improve the curative effect of the drugs.

Description

technical field [0001] The invention relates to the technical field of nano hydrogels, in particular to a polymer nano hydrogel and a preparation method thereof. Background technique [0002] Sustained drug release is the combination of drugs and drug carriers, through diffusion, penetration, etc. in the body, so that the drug can be continuously released at an appropriate concentration, so as to fully exert the efficacy of the drug. Polymers such as polyesters and polyamino acids have become the main materials for drug carriers due to their advantages of non-toxicity, good biocompatibility, and biodegradability. [0003] Polymers usually act as drug carriers in the form of solid polymers, polymer nanomicelles or polymer nanohydrogels. Among them, solid polymers need to be implanted into the human body, which will cause surgical trauma; polymer nanomicelles are nano-sized core-shells formed by self-assembly of amphiphilic block copolymers with hydrophilic blocks and hydroph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G69/40C08G65/48C08J3/24C08J3/075A61K9/00A61K47/34
Inventor 庄秀丽丁建勋高晓晔肖春生汤朝晖陈学思
Owner CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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