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A technology of gliclazide and special tablets, which is applied in the field of gliclazide tablets and its preparation, can solve the problems of unfavorable large-scale production and complex production process, and achieve the effects of reducing the number of medications, simple production process and small environmental impact
Active Publication Date: 2013-07-10
广东彼迪药业有限公司
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Problems solved by technology
However, the production process of this osmotic pump controlled-release tablet is complicated, which is not conducive to large-scale industrial production.
Method used
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Embodiment 1
[0023] Example 1 Preparation of Gliclazide Tablets
[0024]
[0025] Preparation Process:
[0026] Heat the citric acid and polyvinyl acetate to melt, add them to the hot melt extruder, add gliclazide, heat to 100°C, melt, extrude the melt to granulate, and place the extruded granules at room temperature for 2 hours. Then mix with lactose and magnesium stearate evenly, press tablets, and get ready.
Embodiment 2
[0027] Example 2 Preparation of Gliclazide Tablets
[0028]
[0029] Preparation Process:
[0030] Heat the citric acid and polyvinyl acetate to melt, add them to the hot melt extruder, add gliclazide, heat to 100°C, melt, extrude the melt to granulate, and place the extruded granules at room temperature for 2 hours. Then mix with microcrystalline cellulose and magnesium stearate evenly, press tablets, and get it.
Embodiment 3
[0031] Example 3 Preparation of Gliclazide Tablets
[0032]
[0033] Preparation Process:
[0034] Heat and melt citric acid and polyvinyl acetate in a hot melt extruder at 100°C, add gliclazide, melt, extrude the melt to granulate, place the extruded granules at room temperature for 2 hours, and then mix with phosphoric acid Calcium hydrogen and magnesium stearate are mixed evenly and compressed into tablets to obtain.
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Abstract
The invention discloses a gliclazide tablet. The gliclazide tablet is directly tabletted by gliclazide solid dispersoid particles and auxiliary materials accepted pharmaceutically; and the gliclazide solid dispersoid particles are prepared according to the following method: citrate and polyvinyl acetate are heated and molten in a hot melt extruder, then gliclazide is added inside to melt, and the molten liquid is extruded and granulated. The preparation method of the invention is simple in preparation production technology; a patient just takes the medicine once every day, the active components slowly release in the body of the patient, and the plasma concentration is steady; and the gliclazide has long effectiveness, so that the times of administration are reduced, the toxic and side effects are lowered, and the treatment cost is greatly reduced.
Description
Technical field [0001] The invention belongs to the technical field of pharmaceutical solid oral preparations, and specifically relates to a gliclazide tablet and a preparation method thereof. Background technique [0002] Gliclazide (Gliclazide) is a second-generation oral sulfonylurea hypoglycemic agent with a strong effect. Its mechanism is to selectively act on pancreatic islet β cells to promote insulin secretion and increase the release of insulin after eating glucose. Glucose production and output are inhibited. It is suitable for non-insulin-dependent diabetes mellitus (type Ⅱ). It can lower blood sugar in adult diabetic patients. It can reduce platelet adhesion and blood glucose viscosity. It is used for adult diabetes or accompanied by vascular disease. In case of oral administration, the plasma concentration reaches the peak 2~6h, t 1 / 2 About 10 to 12 hours, mainly excreted by the kidneys. [0003] Gliclazide is a white or off-white crystalline powder, which is soluble ...
Claims
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Application Information
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