Dermal filler composition

Abstract

The present invention relates to a novel dermal filler composition and to a method for preparing same. The composition of the present invention comprises, as a main component, cross-linked dextran, the molecular weight of which is 30,000 to 100,000. The composition can rapidly augment a defective area of the skin and maintain softness to the touch even when used alone. The composition eliminates the necessity of a pretreatment, such as an allergy test, which might otherwise be required prior to injection, is inexpensive, and is not easily decomposed or absorbed in vivo, thereby maintaining the tissue-volume augmentation effects thereof over a long period of time after injection. Therefore, the composition is suitable for use in a procedure such as penile augmentation or the like which requires the injection of a large amount of dermal filler, i.e. more than 20 cc. The composition of the present invention can be prepared through a simplified process to make the composition easily usable. The composition is soft to the touch when injected under the skin, and can thus be applicable not only to the skin of the penis but also to the skin of other parts of the human body, Including the face.

Description

technical field [0001] The present invention relates to a new dermal filler composition which can be quickly given any shape after being injected into the body by injection and its preparation method. Background technique [0002] The soft tissue of the human body maintains its structure through proteins such as collagen and elastin and the extracellular matrix containing mucopolysaccharides. When the soft tissue is lost due to congenital reasons, external impact or etiology, etc. Biological tissue or synthetic macromolecular compounds expand soft tissue to restore or correct its shape. A substance similar to skin tissue is injected into a specific site to expand soft tissue, thereby improving wrinkles or correcting contours, etc. Substances are generally called dermal fillers or fillers. Such dermal fillers are divided into the following two types according to the mechanism of their display effects: one type of dermal fillers shows the expansion effect by directly expandin...

AI Technical Summary

Problems solved by technology

However, after the composition is injected under the skin, it feels hard to the touch, so it is suitable for injecting penis enlargement, but it is not suitable for use on many other parts of the body that need a softer touch, such as the face

[0013] In addition, due to the mixed use of two main polymers, the preparation process is complicated and it is difficult to obtain permission for human use, so there is a problem of difficulty in practical application

[0014] In addition, since the polymethyl methacrylate (PMMA) component does not slowly decompose but stays in the living body, it is still difficult to eliminate the fear of the possibility of side effects in the future

[0015] In addition, there are no dermal fillers that use cross-linked dextran alone as a main component in dermal fillers. The reason is that the molecular weight of cross-linked dextran used subtly in all existing dermal fillers is 30,000 or less ( Product name: DEAE Sephadex 25), the bead size in the dry state is 40 μm to 120 μm, when hydrated in 0.15M sodium chloride aqueous solution, the diameter of the median value of the bead size is 127 μm, water The diameter ratio of the melted state / dried state is only 1.83 (converted to a volume ratio of 6.1), so the volume expansion effect is very small, and it is difficult to inject without a carrier, and collagen or hyaluronic acid (hyaluronic acid) must be used The carrier (carrier) has a volume effect, and the touch of the injection site will feel hard due to the hard film formed by tissue reaction

(refer to figure 2 ), therefore, the existing cross-linked dextran is difficult to inject when used alone, and the injection site produces a hard touch, and is not suitable for the single main component of the filler. Materials such as collagen or hyaluronic acid must be added as carriers (carrier ) and main ingredients to use

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