43 results about "Neural Tissue Damage" patented technology

A biocompatible tissue repair stimulating implant or "scaffold" device is used to repair tissue injuries, particularly injuries to ligaments, tendons, and nerves. Such implants are especially useful in methods that involve surgical procedures to repair injuries to ligament, tendon, and nerve tissue in the hand and foot. The repair procedures may be conducted with implants that contain a biological component that assists in healing or tissue repair.

To achieve, an in vivo repair of injured mammalian nerve tissue, an effective amount of a biomembrane fusion agent is administered to the injured nerve tissue. The application of the biomembrane fusion agent may be performed by directly contacting the agent with the nerve tissue at the site of the injury. Alternatively, the biomembrane fusion agent is delivered to the site of the injury through the blood supply after administration of the biomembrane fusion agent to the patient. The administration is preferably by parenteral administration including including intravascular, intramuscular, subcutaneous, or intraperitoneal injection of an effective quantity of the biomembrane fusion agent so that an effective amount is delivered to the site of the nerve tissue injury.

Systems, delivery devices, and methods to treat to ablate, damage, or otherwise affect tissue. The treatment systems are capable of delivering energy to nerve tissue in a target region such that at least a portion of the nerve tissue is replaced by scar tissue or otherwise altered to inhibit reinnervation in the target region.

A biocompatible tissue repair stimulating implant or “scaffold” device is used to repair tissue injuries, particularly injuries to ligaments, tendons, and nerves. Such implants are especially useful in methods that involve surgical procedures to repair injuries to ligament, tendon, and nerve tissue in the hand and foot. The repair procedures may be conducted with implants that contain a biological component that assists in healing or tissue repair.

The present invention provides methods of identifying markers indicative of the risk of developing a neurodevelopmental disorder caused in part by antibody- or autoantibody-mediated damage of neural tissue, including autism spectrum disorder (ASD). The invention further provides methods of diagnosing whether an individual has a neurodevelopmental disorder, including an ASD, and methods for determining the risk that a mother's future offspring will develop an a neurodevelopmental disorder, including an ASD.

The present invention relates to the use of plasminogen in the prevention and / or treatment of diabetic neuropathic pain and neurohypersensitivity, and in the repair of nerve tissue injury. Therefore, plasminogen may become a new strategy for preventing and treating diabetic neuropathic pain.

A method for treating a degenerative or traumatic injury to a nerve tissue or the brain by administering at or near the injury site a composition containing adherent bone marrow stem cells suspended in a pharmaceutically acceptable liquid in an amount effective to elicit axonal regeneration or re-myelination at the site of injury.

The invention relates to a biological material used to recover hurt brain. Wherein, it uses transparent hyaluronic acid as raw material, guided by carbodiimide hydrochlorate (EDC), to use adipic acid adipoyl (ADH) to cross, to obtain the hyaluronic acid gel, as the carrier of graft antibody; and uses antibody solidification technique to graft the antibodies of axon growth restrain factor MAG, OMgp and Nogo-A to the hyaluronic acid gel, to be the antibody transfer system carrying special antibody and sensitive to pH value. The invention can be used to seal the never axon regeneration restrain factor of myelin and accelerate the regeneration of hurt brain organism.

The invention discloses an intervertebral foramen puncture guide device which comprises a vertical positioning device, a horizontal adjusting device and an angle adjusting device, wherein the vertical positioning device is connected with the horizontal adjusting device by a longitudinal-transverse rod connector; the angle adjusting device is connected with the horizontal adjusting device; an intervertebral foramen puncture sleeve is fixed on the angle adjusting device; and an intervertebral foramen puncture needle penetrates in the intervertebral foramen puncture sleeve. In the invention, based on the principle that two points define a straight line and through the guide of a zygopophysis puncture needle and the intervertebral foramen puncture needle sleeve, accurate intervertebral foramen puncture can be realized conveniently, accurately and quickly; only a little and simple X perspective is needed during the operation, and thus the ray exposure of the medical personnel and patients is reduced; and due to the guide of the zygopophysis puncture needle, the puncture blindness is avoided, the risk of vascular nerve tissue damage is reduced, the puncture accuracy and safety are guaranteed, the operation time is shortened, the device is easy to learn and understand, the learning period is shortened, and the efficiency is improved.

The invention provides novel pyridines, pharmaceutical compositions comprising such pyridines, and the use of such compositions in treating injured mammalian nerve tissue, including but not limited to an injured spinal cord. In one embodiment, the compounds, compositions, and methods of the instant invention treat a mammalian nerve tissue injury by restoring action potential or nerve impulse conduction through a nerve tissue lesion. Significantly, in vivo application of compounds of the instant invention established, on the basis of SSEP testing, that the compounds provide longer lasting effects at lower concentrations than comparable treatment with the known agent 4-aminopyridine (4 AP).

The present invention relates to a pharmaceutical composition for preventing or treating neuronal damage and neurological diseases, and more particularly, to a pharmaceutical composition for preventing or treating neuronal damage and neurological diseases containing, as active ingredients, any one or two or more compounds selected from a group consisting of the compound of chemical formula 1, the compound of chemical formula 2, and the acceptable salts thereof.The pharmaceutical composition repairs nerve tissue damaged by herpes zoster to reduce the acute pain caused by herpes zoster, prevents postherpetic neuralgia, and enables a fundamental treatment through the recovery of nerve tissue in the postherpetic neuralgia. Further, the pharmaceutical composition can be effectively used for neuronal damage, including sciatic nerve crushing damage or the like, in a neuropathy including diabetic neuropathy or the like and for neuropathic pain, as well as for a variety of diseases caused by nerve tissue damage, such as brain diseases including strokes or the like.

To achieve, an in vivo repair of injured mammalian nerve tissue, an effective amount of a biomembrane fusion agent is administered to the injured nerve tissue. The application of the biomembrane fusion agent may be performed by directly contacting the agent with the nerve tissue at the site of the injury. Alternatively, the biomembrane fusion agent is delivered to the site of the injury through the blood supply after administration of the biomembrane fusion agent to the patient. The administration is preferably by parenteral administration including intravascular, intramuscular, subcutaneous, or intraperitoneal injection of an effective quantity of the biomembrane fusion agent so that an effective amount is delivered to the site of the nerve tissue injury.

A composite nerve conduit comprising an elongated body comprising one or more hollow elongated internal channels for guiding and promoting nerve regeneration. The conduit is a three-dimensional scaffold comprising a crosslinked hybrid / composite matrix of collagen and soy protein isolate having improved mechanical and biocompatibility properties. Methods of using the conduit for promoting nerve regeneration at a site of neural tissue damage by bridging wounded, severed, or damaged nerve sections in a peripheral and / or central nervous system. Methods of fabricating composite neural conduits are also disclosed.

Systems, delivery devices, and methods to treat to ablate, damage, or otherwise affect nerve tissue such that reinnervation is inhibited. The treatment systems are capable of delivering energy to nerve tissue in a target region such that at least a portion of the nerve tissue is replaced by scar tissue or otherwise altered to inhibit reinnervation in the target region.

The present invention relates to drug screening methods and methods of preventing neural tissue damage caused by α-synuclein aggregation. These methods are especially useful in the design and development of inhibitors of Lewy body diseases and other synucleinopathies, and further useful in the treatment of such neurodegenerative diseases, particularly Parkinson's Disease.

The invention discloses a plaster for treating cervical spondylosis and lumbar spondylosis and belongs to the technical field of plaster preparations. The plaster comprises a vector (1), an outer plaster (2) and an inner plaster (3), wherein the inner plaster (3) is arranged between the outer plaster (2) and the vector (1); the coating area of the outer plaster (2) is greater than that of the inner plaster (3); a coating region of an inner plaster body is positioned inside a plaster coating region of the outer plaster (2). The plaster can be used for effectively treating spondylodynia, repairing connective tissue and nerve tissue damages caused by spondylodynia and relieving spinal disease complications, and the plaster is low in allergic rate and does not mould and lose the pharmacological effect after being stored for a long period of time. According to the preparation method of the plaster, the plaster is purified by adopting an oil-soaking extraction mode or an ethyl alcohol and water mixed liquor extraction mode, and the obtained outer plaster can have the effects of preventing corrosion, inhibiting bacteria, resisting allergy and preventing the inner plaster from being aired and crushed.

The invention discloses applications of L-serine or medicinal salts thereof in preparing medicaments used for preventing and treating brain injuries and nerve tissue injuries. The research finds that the L-serine is capable of significantly improving the neural functional grade of a mouse with traumatic brain injuries, reducing brain tissue loss after being injured, alleviating hippocampal neuron neuronal degeneration and necrosis significantly, and improving learning and memory functions. The applications of the L-serine as a nerve protection medicine in treating acute injuries caused by the brain injuries are disclosed for the first time.

It is intended to provide an animal model of urinary dysfunction induced by damage in brain nerve tissue in a small animal conveniently and at a high reproducibility. A rat in which the central urinary function alone is specifically damaged by regionally injuring the brain superior colliculus with the use of a legion generator. The animal model of urinary dysfunction is useful in a method of screening a therapeutic agent for urinary dysfunction.

The invention discloses a nerve stimulator circuit based on rapid charge balance in a mixed mode. The nerve stimulator circuit comprises a main stimulation part, an electrode short-connecting part anda short current pulse part, the main stimulation part comprises a current source and n pairs of output switches, and each pair of output switches corresponds to an electrode; the electrode short-connecting part comprises n short-connecting switches; and the short current pulse part comprises a window comparator, a control unit, a compensating current unit and n pairs of selective switches, each pair of selective switches corresponds to an electrode, the voltage difference on the electrodes is monitored and compared with safety voltage VW, the output end of the window comparator is connected with the control unit, if the voltage difference exceeds the safety voltage VW, a short current pulse compensating difference value is interpolated, and monitoring and comparing are continued till thevoltage on the electrodes is less than the safety voltage VW. The nerve stimulator circuit can still realize charge balance in a short time, and the situation that charge is accumulated on the electrodes, consequently, the electrodes are electrolyzed, and nervous tissue is damaged is avoided under the situation of one-way large current stimulation or asymmetric two-way large current stimulation.

The invention discloses an intervertebral foramen puncture guide device which comprises a vertical positioning device, a horizontal adjusting device and an angle adjusting device, wherein the vertical positioning device is connected with the horizontal adjusting device by a longitudinal-transverse rod connector; the angle adjusting device is connected with the horizontal adjusting device; an intervertebral foramen puncture sleeve is fixed on the angle adjusting device; and an intervertebral foramen puncture needle penetrates in the intervertebral foramen puncture sleeve. In the invention, based on the principle that two points define a straight line and through the guide of a zygopophysis puncture needle and the intervertebral foramen puncture needle sleeve, accurate intervertebral foramen puncture can be realized conveniently, accurately and quickly; only a little and simple X perspective is needed during the operation, and thus the ray exposure of the medical personnel and patients is reduced; and due to the guide of the zygopophysis puncture needle, the puncture blindness is avoided, the risk of vascular nerve tissue damage is reduced, the puncture accuracy and safety are guaranteed, the operation time is shortened, the device is easy to learn and understand, the learning period is shortened, and the efficiency is improved.

Pharmaceutical compositions are provided which include a microRNA pool capable of promoting, stimulating or increasing neuronal differentiation, as well as methods for treating, ameliorating and / or preventing depression or diseases where damage to nervous tissue occurs, such as neurological diseases, by means of such microRNA pool.

The present invention provides methods of identifying markers indicative of the risk of developing a neurodevelopmental disorder caused in part by antibody- or autoantibody-mediated damage of neural tissue, including autism spectrum disorder (ASD). The invention further provides methods of diagnosing whether an individual has a neurodevelopmental disorder, including an ASD, and methods for determining the risk that a mother's future offspring will develop an a neurodevelopmental disorder, including an ASD.

The invention relates to the technical field of plaster processing, in particular to a plaster for treating cervical spondylosis and lumbar spondylosis and a preparation method thereof. The plaster comprises the following main components: 1-3 parts of corydalis tuber, 1-3 parts of corydalis amabilis, 1-3 parts of salvia miltiorrhiza, 1-3 parts of peach kernels, 1-3 parts of radix cyathulae, 1-3 parts of pseudo-ginseng, 1-3 parts of safflower carthamus, 1-3 parts of rhizoma bletillae, 1-3 parts of rhizoma sparganii, 3-4 parts of olibanum, 1-3 parts of myrrh, 3-4 parts of draconis sanguis and 1-2 parts of rosin. The plaster can effectively treat spondylodynia, repair the damage of connective tissues and nerve tissues caused by the spondylodynia and relieve spondylodynia complications, and has low allergy rate; and after long-term storage, the plaster does not mildew or lose the drug effect.

Described is a low voltage, pulsed electrical stimulation device (bioelectric stimulator associated with electrodes) for controlling expression of S100 protein(s) by cellular tissues. The bioelectric stimulator is useful in methods to treat a subject suffering from bladder, heart, and / or nerve tissue damage.

A method for treating a degenerative or traumatic injury to a nerve tissue or the brain by administering at or near the injury site a composition containing adherent bone marrow stem cells suspended in a pharmaceutically acceptable liquid in an amount effective to elicit axonal regeneration or re-myelination at the site of injury.