41 results about "Urinary function" patented technology

Systems and methods treat urologic dysfunctions by implanting a lead and electrode in a tissue region affecting urologic function, and coupling the lead to an external pulse generator. If desired results are achieved, the external pulse generator is removed and an implantable pulse generator is implanted in an anterior pelvic region remote from the electrode. Bilateral stimulation of the left and / or right branches of the dorsal genital nerves using a single lead implanted in adipose or other tissue in the region at or near the pubic symphysis is able to treat urologic dysfunctions.

Systems and methods provide a stimulation electrode assembly comprising an elongated lead sized and configured to be implanted within an adipose tissue region. The lead includes an electrically conductive portion to apply electrical stimulation to nerve or muscle in the adipose tissue region and at least one expandable anchoring structure deployable from the lead to engage adipose tissue and resist dislodgment and / or migration of the electrically conductive portion within the adipose tissue region.

A system and method for assessing urinary function is provided. The system includes a processor, a tubing assembly forming a first fluid conduit between a first fluid inlet and a first fluid outlet, and an insert member having a channel therethrough and coupled to the first fluid outlet so that fluid flowing through the first fluid conduit may flow through the insert member. The insert member is dimensioned for at least partial insertion into a patient's urethral canal distal of the patient's urethral sphincter, and dimensioned so that, when inserted, it substantially blocks fluid flow into or out of the urethral canal other than through the insert member channel. The system further includes a fluid delivery device electrically coupled to and controlled by the processor, and coupled to the first fluid conduit for pumping fluid therethrough, and a pressure detection system for detecting pressure within the urethral canal distal of the urethral sphincter and providing information correlating to the detected pressure to the processor. The method includes coupling the test module to the control device, inserting the insert member into a patient, infusing fluid through the insert member until the urethral sphincter opens, and measuring pressure within the urethral canal as fluid is infused therein. Also provided is a test module for coupling to a control device to form a system for assessing urinary function.

A portable, self-contained medical diagnostic system is provided for assessing urinary function. The system includes a control device including a processor, a pump device, and a pressure sensor, and a test module removably coupled to the control device, and further including a pressure interface and a tubing assembly defining a first fluid conduit between a first fluid inlet and a first fluid outlet. The pump device is coupled to the first fluid conduit for pumping fluid therethrough. The system also includes an insert member having a first channel therethrough and coupled to the first fluid outlet so that fluid flowing through the first fluid conduit may flow through the first channel. The insert member is dimensioned for insertion into a patient's bladder through the urethral canal. When so inserted, the pressure interface transmits bladder pressure information to the pressure sensor.

An insertion device is provided for use in assessing urinary function. The insert device includes an insert member for at least partial insertion into a patient's urethral canal having a length such that it is positioned distal of the urethral sphincter, and having an outer surface at least a portion of which is configured to engage the inner wall of the urethra to substantially prevent fluid flow therebetween. The insert member has a channel therethrough through which fluid from a fluid source can be introduced into the urethral canal. Also provided is a device for introducing fluid into a patient's urethral canal including a hand-sized casing having a fluid conduit therein between a fluid inlet and a fluid source assembly. The device further includes an activation device movable between a first position wherein it does not obstruct the fluid conduit and a second position wherein it does obstruct the fluid conduit. An insert member is coupled to a distal end of the hand-sized casing and has a channel therethrough between a fluid inlet and a fluid outlet, and is dimensioned for at least partial insertion into the patient's urethral canal distal of the urethral sphincter. The insert member channel is in fluid communication with the fluid conduit.

Compounds having formula (I) or formula (II) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A, N, X, Y, R1, R2 and R3 are as defined in the specification. These compounds are particularly useful in the treatment of pain, inflammatory hyperalgesia, and urinary dysfunctions, such as bladder overactivity and urinary incontinence.

An apparatus for treating urinary incontinence comprises an electrically powered stimulation device that electrically stimulates the urethral sphincter of a urinary incontinent patient and a hand-held wireless remote control that controls the stimulation device. A stress or urge incontinent patient operates the remote control to: i) switch off the electrically powered stimulation device, when the patient wants to urinate, and switch on the electrically powered stimulation device, when the patient has finished urinating; and ii) control the stimulation device as needed at any time over the course of a day to promptly adjust the intensity of the electric stimulation of the urethral sphincter to quickly increase the tonus of the urethral sphincter.

A medical system is provided that includes a control device and a plurality of modules each capable of being removably coupled to the control device. When a first one of the plurality of modules is removably coupled to the control device, the medical system is capable of performing a test to assess urinary function, and when a second one of the plurality of modules is removably coupled to the control device, the medical system is capable of performing endometrial ablation.

Disclosed are a urinary function measuring device for animals and a urinary function measuring method for animals capable of sampling the amount of animal urine with high accuracy. Specifically disclosed is a urinary function measuring device which comprises an accommodating unit that accommodates an animal other than humans; a collecting unit that is disposed below the accommodating unit and collects urine discharged by the animal in the accommodating unit; a reticulated unit that is disposed below the accommodating unit, allows passage of the urine of the animal to the collecting unit, and collects objects other than the urine; a measuring unit that measures the weight of the urine collected by the collecting unit; and a data recording unit that records the data measured by the measuring unit. The diameter of the net of the reticulated unit is less than or equal to 0.5 mm, and the size of the mesh of the reticulated unit is more than or equal to 1 mm2 and less than or equal to the maximum mesh size determined by at least either the excretions of the animal accommodated in the accommodating unit or a predetermined object used for accommodating the animal in the accommodating unit.

The present invention relates to high-throughput mammalian and medium-throughput oocyte-based electrophysiological assays for identifying human TRPML3 modulators, preferably TRPML3 enhancers. Compounds that modulate TRPML3 function in the assay are expected to affect salty taste in humans. The inventive electrophysiological assays, such as the two-electrode voltage-clamp technique, facilitate the identification of compounds which specifically modulate human TRPML3. The assays of the invention provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit TRPML3 function. Compounds that enhance or block TRPML3 channel activity should thereby modulate salty taste. In addition, these compounds may be used to regulate sodium excretion, urinary output and other biological functions relating to sodium levels. This invention relates to the elucidation that TRPML3 is involved in salty taste perception in primates including humans and likely other mammals (given the significance of sodium and other ions to physiological functions and conditions this phenotype is likely strongly conserved in different animals). The TRPML3 gene also modulates one or more of sodium metabolism, sodium excretion, blood pressure, fluid retention, cardiac function and urinary functions such as urine production and excretion. The inventors have identified TRPML3 as encoding a salty taste receptor in primates and humans (and likely other mammals) based on gene expression assays which have determined that TRPML3 is expressed specifically in taste bud cells and not in lingual epithelial cells, similar assays that have determined that TRPML3 is specifically expressed or enriched in the top half of taste bud cells in a subset of taste cells which do not express TRPM5 or PKD2L1, prior reports that document the expression of TRPML3 in other sensory organs such as the ear (therefore further substantiating the role of TRPML3 as a 'professional' sensory gene).

Device and method for correcting urinary incontinence and urinary retention, by implanting a urinary flow control device for elective user control of urinary function in male and female patients. The device is a mechanical valve to a natural or artificial bladder, and includes a to reach the abdominal wall of the patient. Preferably a bladder anti-prolapse skirt is attached between the bladder and control valve. The device provides a urine flow channel that passes through the valve from one side to the other of a valve seat where an actuator with a mating stopper is controlled to open and close the valve at the election of the user with an external controller. The valve is an occlusion type (seat with stopper), or a pinch type. The flow channel may be an artificial urethra passing through a pinch valve.

A therapeutic device for thermally assisted urinary function is presented. The therapeutic pad (14) is composed of an upper thermal element (18) and a lower thermal element (19) having a portal (15), both elements substantially cup-shaped to cover and contact the groin. The therapeutic pad (14) is composed of a material sufficiently capable of storing energy from either an external or internal source. The therapeutic pad (14) communicates stored energy as heat to tissues comprising the groin and regions adjacent thereto. The portal (15) allows for the unimpeded flow of urine from the urinary tract into a receptacle. A variety of alternate embodiments are provided, including lift tabs (17a, 17b), an extension element (35) for heating the perineum, a portal sleeve (23) for heating the penis, a slit (34) which bisects the therapeutic pad (14) and portal sleeve (23), a pair of rings (26, 27) to open and close the slit (34), an interior cover (30) about the therapeutic pad (14) for applying moist heat, and support elements (31) along the therapeutic pad (14).

A single use device for capturing fecal matter excreted from the anus of a user. The device includes a flexible fecal matter container having a closed end and an opening that is in fluid communication with a volume enclosed by the flexible container. An adhesive is disposed about the opening of the flexible container and has a first side that is secured to the flexible container. A second side of the adhesive is constructed to be removably applied to the epidermis of the user proximate an anal opening of the user. The adhesive is shaped to cooperate with the epidermis to circumscribe the anus in a sealed manner without interfering or overlapping anatomy associated with urinary function or medical devices, such as a catheter, associated therewith.

Preventives / remedies for voiding disturbance containing a compound having both of an acetylcholinesterase inhibitory action and an alpha1 antagonistic action which exhibits an excellent effect of improving the urinary function of the bladder (i.e., effects of improving urine flow rate and voiding efficiency) without affecting the urinary pressure or the blood pressure.

The invention provides a medicament for treating prostatitis and prostatic hyperplasia, and belongs to a medicament which is prepared from Chinese medicaments serving as raw materials for treating prostatitis and benign prostatic hyperplasia. The medicament is prepared from rheum officinale, herba lycopi, mirabilite, folium artemisiae argyi, leonurus, fig, plantain herb, wild chrysanthemum, houttuynia cordata, sophora flavescens, angelica root,cassia twig, golden cypress and the like. The medicament has the effects of activating blood and dissolving stasis, clearing heat and removing toxicity, and relieving pains and spasm, can reduce urethral obstruction and improve urinary function, and has low treatment cost, convenient administration, quick response and good treatment effect. Use of 200 clinical cases proves that: the effective rate is 99 percent, and the cure rate is 94.5 percent.

A medicine for treating kidney calculi in the invention contains the following raw materials of: by weight, 6-8 parts of Rhamnella gilgitica Mansf. Melch., 8-10 parts of changuienia amoena chien, 6-8 parts of Gymnema yunnanense Tsiang, 3-5 parts of evening primrose, 8-10 parts of common adenostema herb, 8-10 parts of Lysimachia congestiflora Hemsl, 2-4 parts of dry maidenhair fern herb, 3-5 partsof Chinese cassia tree, 6-8 parts of bighead atractylodes rhizome, 6-8 parts of Poria cocos, 3-5 parts of gentrin knotweed, 2-4 parts of desmodium, 4-6 parts of Lygodium japonicum, 2-4 parts of SemenAbutili, 3-5 parts of plantago, 4-6 parts of radix bupleuri, 6-8 parts of oriental waterplantain rhizome, 3-5 parts of rheum officinale, 4-6 parts of white peony root, 1-3 parts of Artemisia capillaries and 1-3 parts of curcuma tuber. The medicine provided by the invention has effects of invigorating kidney qi, increasing functioning of bladder, keeping urinary function normal, dissolving stone, expelling stone, reducing renal colic and ureteral smooth muscle spasm, promoting qi circulation and relieving pain, clearing heat and draining dampness, and draining calculus. The effect of rushing, dissolving and draining calculus can be reached. In addition, the medicine provided by the invention has advantages of good curative effect, little side-effect and low cost.

An intelligentized bladder urinary function controller is characterized by comprising a bladder surface control-sensing film (1), a catheter (2) and an intelligent controller (3). The bladder surface control-sensing film (1) is connected with the catheter (2) which comprises a pressure sensor afferent fiber (20) and an electromechanical contraction reactor dominating efferent fiber (21), the intelligent controller (3) comprises a pressure change sensor (30) and a microprocessor (31), and the pressure sensor afferent fiber (20) and the electromechanical contraction reactor dominating efferent fiber (21) are respectively connected with the intelligent controller (3). The intelligentized bladder urinary function controller is implanted into a body by minimally invasive surgery to control filling, urine retention and dysfunction of bladder after spinal cord injury so as to restore normal urinary function of the bladder to the greatest extent.

It is intended to provide an animal model of urinary dysfunction induced by damage in brain nerve tissue in a small animal conveniently and at a high reproducibility. A rat in which the central urinary function alone is specifically damaged by regionally injuring the brain superior colliculus with the use of a legion generator. The animal model of urinary dysfunction is useful in a method of screening a therapeutic agent for urinary dysfunction.

The invention discloses a Chinese medicinal preparation for treating renal calculus and a preparation method thereof, belonging to the field of traditional Chinese medicine. The active ingredients of the Chinese medicinal preparation are prepared from the following raw materials: polygonum aviculare, plantain seed, pink herb, chicken gizzard membrane, mirabilite, common burreed rhizome, cowherb seed, officinal magnolia bark, common cephalanoplos herb, Chinese honeylocust spine, rust-brown crotalaria, fragrant solomonseal rhizome, ricepaper pith, longhairy antenoron herb, Indian buead and pyrrosia leaf. The Chinese medicinal preparation has the effects of diminishing inflammation, relieving pain, promoting blood circulation to remove blood stasis, promoting the circulation of qi, removing stasis, inducing diuresis and expelling calculi, is suitable for renal calculus patients having the symptoms of waist aching pain, generalized weakness, unsmooth urination, hematuresis and the like, has remarkable curative effect, and is free of toxic and side effects, and low in cost. The Chinese medicinal preparation is strict in compatibility, has the effects of supplementing kidney qi, improving the gasifying function of urinary bladder, promoting normal urinary function, dissolving calculi and removing urinary calculi, is high in safety, and contributes to relieving pain of patients in time.

A method and device for urinary function control. The method comprises selecting neuro-electrical coded signals, which are similar to those naturally generated within the body, from a storage area that are representative of urinary function. The selected neuro-electrical coded signals are then transmitted or conducted to a treatment member, which is in direct contact with the body, and which then broadcasts the neuro-electrical coded signals to a specific urinary nerve to modulate the urinary function. A control module is provided for transmission to the treatment member. The control module contains the neuro-electrical coded signals which are selected and transmitted to the treatment member, and computer storage can be provided for greater storage capacity and manipulation of the neuro-electrical coded signals.

The invention discloses a traditional Chinese medicine composition for treating kidney stone. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-20 parts of honeysuckle, 10-20 parts of fructus forsythia, 10-20 parts of golden cypress, 10-20 parts of lysimachia christinae hance, 5-15 parts of pyrrosia lingua, 20-30 parts of lygodium japonicum, 5-15 parts of chicken gizzard-membrane, 20-30 parts of talc, 5-15 parts of blastus ernae, 15-30 parts of achyranthes roots, 10-20 parts of radix angelicae tuhuo, 10-15 parts of eucommia ulmoides and 10-30 parts of misgurnus bipartitus. The traditional Chinese medicine composition has the effects of diminishing inflammation and reliving pain as well as promoting urea and expelling stone, is applicable to kidney stone patients with symptoms of urination difficulty and the like, is capable of well relieving pain of patients, gradually expelling stone and promoting urinary function normality, even has an effect of completely expelling kidney stone, and is safe and free of side effect.

The invention discloses a medicament for curing bed-wetting and uroclepsia which is prepared by 13 material medicines comprising Fructus Psoraleae, shizandra berry, raspberry, calcined oyster shell, Cynomorium songaricum, acanthopanax, dodder, Fructus Alpiniae Oxyphyllae, Morinda officinalis, medlar, radix codonopsitis, polygonatum and mantis egg-case. The medicament for curing bed-wetting and uroclepsia can warm kidney yang, induce resuscitation, and tranquilize mind. The pneuma of the kidney is thriving, the astringency is right, the bladder is properly opened and closed, and then the urinary function is normal. Observing from 260 cases of patients who take the medicament, the cure rate can reach more than 90 percent and the total effective rate is 100 percent.

The invention discloses an abdominal pressure triggering type stress incontinence rehabilitation method and a therapeutic apparatus. The method and the apparatus are aimed at the pathogenesis and the brain regulatory mechanism, and the overall rehabilitation of the urinary function nervous system and the pelvic floor muscle function is promoted. According to the method, a host unit and left, middle and right vibration units are fixed to a lower abdomen through a unit combined waistband. An abdominal wall stretching (pressure) sensor is stimulated by physical vibration conforming to the physiological features of a human body, and trigger factors (abdominal pressure increase) of the stress incontinence are directly simulated. After a brain receives transmitting signals from the abdominal wall, the shrinkage and relaxation of pelvic floor muscles are controlled. Through the repeated training, the active control of the brain over the pelvic floor muscles is enhanced, and the shrinkage function, happening after the abdominal pressure increase, of the pelvic floor muscles is effectively improved. Through the biological feedback type combination of the method, the pressure variation between two side hips generated by the shrinkage and relaxation of the pelvic floor muscles is directly detected through a perineum pressure sensor, a perineum vibration unit is triggered, biological feedback information with local body feelings as the feature is formed and transmitted to the brain, and the rehabilitation training effect is improved.

The invention discloses an intubation-free negative pressure suction urethral catheterization device in the intubation-free urethral catheterization technology. The device is composed of a vacuum pump, a urine storage bottle and a covering cup, which are connected through ducts. The vacuum pump promotes urethral peripheral tissues to generate centrifugal expansion through suction force generated by the covering cup when forming negative pressure, and the covering cup generates urethral passive traction to expand the urethral lacuna to facilitate outflow of urine. An additional vibration massager massages the bladder part and related acupuncture points to induce bladder contraction so as to recover the urinary function. When not in use, no catheter is needed to be inserted to avoid infection, pain and such complications as mucosa damage, etc.

The present invention relates to the technical field of medical dressings, in particular to a medical biological urinary hydrogel functional dressing and a preparation method thereof. The medical biological urinary hydrogel functional dressing is composed of the following raw materials in percentage by weight: glycerin, chitosan quaternary ammonium Salt, peppermint extract, polyhexamethylene guanidine, Solanum nigrum extract, Akebia extract, gardenia extract, Qumai extract, talc powder, Kochia chinensis extract, Tianjihuang extract, Commelina extract liquid, light bamboo leaf extract, and the balance of purified water. The medical biological urinary hydrogel functional dressing of the present invention has little irritation, no toxic and side effects, safe use, good permeability, good curative effect, can give full play to the drug effect, has a long duration of action, and is not easy to relapse. When used in the anus, it directly penetrates into the prostatic body through the anal wall membrane, and can be widely used in the treatment of prostatitis, chronic benign prostatic hyperplasia, abscess caused by hypertrophy, urgency, frequent urination, and painful urination.

The invention discloses a traditional Chinese medicine composition for preventing and curing a stone and an application thereof. The traditional Chinese medicine composition is composed of canna flowers, quamoclit pennata and peach kernels. The peach kernels which can promote blood circulation and remove meridian obstruction and detoxify serve as the main medicine. The form canna flowers which can promote blood circulation and remove meridian obstruction serve as the auxiliary medicine. The quamoclit pennata which can clear away heat, detoxify, cool blood and diminish inflammation and swelling are added. The medicine is added together. The effects of blood circulation promoting, meridian obstruction removing, collateral dredging, inflammation diminishing, swelling diminishing, detoxifying and stone removing can be achieved. According to the traditional Chinese medicine composition, the effects of inflammation and swelling diminishing, blood circulation promoting and blood stasis removing, hemostasis and pain relieving, qi circulation promoting, diuresis and stone removing can be achieved. The traditional Chinese medicine composition is suitable for patients who are painful in waist, weak in whole body and unsmooth in urination and have hematuresis and other symptoms. The treatment efficacy is obvious, the poisonous side effects do not exist, and the cost is low. The pain on the kidney stone patients can be relieved, the spasm of a ureter and the urethra can be relieved, the urinary function is favorable to be normal, and the obvious stone removing and pain relieving effects are achieved.

The invention discloses an application of an adenosine receptor antagonist in preparation of a medicine for treating bladder and urinary dysfunction of mammals. The adenosine receptor antagonist can effectively increase bladder capacity and reduce urination frequency.