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Applications of L-serine in preparing medicines used for treating brain injuries and nerve tissue injuries

A serine, brain injury technology, applied in drug combinations, nervous system diseases, etc., can solve the problems of high safety factor and small side effects, and achieve the effect of high safety factor, small side effects, and obvious neuroprotective effect.

Inactive Publication Date: 2013-12-04
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] This study found for the first time that L-serine can significantly improve motor function after TBI, enhance neuroplasticity and learning and memory ability, reduce brain tissue damage, and prevent neurodegeneration at the same time. L-serine may be a very potential neuroprotective agent for TBI. It has less side effects and higher safety factor. At present, there is no report on the application of L-serine in the treatment of traumatic brain injury at home and abroad.

Method used

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  • Applications of L-serine in preparing medicines used for treating brain injuries and nerve tissue injuries
  • Applications of L-serine in preparing medicines used for treating brain injuries and nerve tissue injuries
  • Applications of L-serine in preparing medicines used for treating brain injuries and nerve tissue injuries

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Experimental program
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Embodiment Construction

[0029] 1. Experimental materials and methods

[0030] 1.1 Experimental animals and grouping

[0031] Clean grade adult male C57 / BL6 mice (provided by the Animal Center of the Chinese Academy of Sciences), 8-10 weeks old, 25-28g, the animals were raised in the animal room of the laboratory for 2-3 days before operation, free to eat and drink, room temperature 20-22°C, Daily light 12h / dark 12h, so that the animals adapt to the environment. The behaviorally trained mice were randomly divided into sham operation group, control group, and L-serine group (168 mg / kg), with 8 mice in each group. Neurological function tests and water maze tests were performed at each time point. Finally, perfusion, Fixed, sliced ​​for histological staining, and observed for 5 weeks after operation. Corresponding doses of L-serine were intraperitoneally injected 2 hours after TBI, and the same volume of normal saline was injected into the sham operation group and control group.

[0032] 1.2 Model pre...

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PUM

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Abstract

The invention discloses applications of L-serine or medicinal salts thereof in preparing medicaments used for preventing and treating brain injuries and nerve tissue injuries. The research finds that the L-serine is capable of significantly improving the neural functional grade of a mouse with traumatic brain injuries, reducing brain tissue loss after being injured, alleviating hippocampal neuron neuronal degeneration and necrosis significantly, and improving learning and memory functions. The applications of the L-serine as a nerve protection medicine in treating acute injuries caused by the brain injuries are disclosed for the first time.

Description

Technical field: [0001] The present invention relates to a new medical application of L-serine. Specifically, the present invention relates to the application of L-serine in the preparation of drugs with neuroprotective effect, anti-acute brain injury and nerve tissue injury. Background technique: [0002] Traumatic brain injury (traumaitc brain injury, TBI) is one of the common emergencies in the field of neurosurgery, especially severe TBI, with a mortality rate of 30%-50%; Disability, while moderate and severe patients can reach 66% and 100% (Masel BE, DeWitt DS. Traumatic brain injury: a disease process, not an event. J Neurotrauma, 2010,27(8):1529-1540; Maas AI , Stocchetti N, Bullock R. Moderate and severe traumatic brain injury in adults. Lancet Neurol, 2008, 7(8):728-741). TBI has become the first cause of death and disability among young adults under the age of 35 in the world (Aarabi B, Simard JM. Traumatic brain injury. Curr Opin Crit Care, 2009, 15(6): 548-553)...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61P25/00
Inventor 姜正林王国华李霞高艳琴陈俊
Owner NANTONG UNIVERSITY
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